scholarly journals Lewis, Rat Strain

2020 ◽  
Author(s):  
Keyword(s):  
Lewis Rat ◽  
Rat Strain

Influence of extenders and cooling rates on epididymal sperm of Lewis rat strain

2015 ◽  
Vol 62 (1) ◽  
pp. 57-62 ◽  
Author(s):  
VARIŞLI Ömer; AGCA
Keyword(s):  
Lewis Rat ◽  
Epididymal Sperm ◽  
Cooling Rates ◽  
Rat Strain

Behavioral, neuroendocrine and serotonergic consequences of single social defeat and repeated fluoxetine pretreatment in the Lewis rat strain

Neuroscience ◽  
1999 ◽  
Vol 92 (1) ◽  
pp. 327-341 ◽  
Author(s):  
O. Berton ◽  
M. Durand ◽  
S. Aguerre ◽  
P. Mormède ◽  
F. Chaouloff
Keyword(s):  
Social Defeat ◽  
Lewis Rat ◽  
Rat Strain

scholarly journals Rat strain differences in pilocarpine-induced mouse killing

1976 ◽  
Vol 4 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Patricia E. Gay ◽  
Russell C. Leaf
Keyword(s):  
Strain Differences ◽  
Mouse Killing ◽  
Rat Strain

POSSIBLE ROLE OF 5α-ANDROSTANE-3α,17β-DIOL IN THE CONTROL OF FOLLICLE-STIMULATING HORMONE SECRETION IN THE IMMATURE FEMALE RAT

1982 ◽  
Vol 92 (1) ◽  
pp. 37-42 ◽  
Author(s):  
H. M. A. MEIJS-ROELOFS ◽  
P. KRAMER ◽  
L. GRIBLING-HEGGE
Keyword(s):  
Inhibitory Action ◽  
Combined Treatment ◽  
Hormone Secretion ◽  
Inhibitory Effect ◽  
Ovariectomized Rats ◽  
Female Rat ◽  
Immature Rat ◽  
Rat Strain ◽  
Intact Rats

A possible role of 5α-androstane-3α,17β-diol (3α-androstanediol) in the control of FSH secretion was studied at various ages in ovariectomized rats. In the rat strain used, vaginal opening, coincident with first ovulation, generally occurs between 37 and 42 days of age. If 3α-androstanediol alone was given as an ovarian substitute, an inhibitory effect on FSH release was evident with all three doses tested (50, 100, 300 μg/100 g body wt) between 13 and 30 days of age; at 33–35 days of age only the 300 μg dose caused some inhibition of FSH release. Results were more complex if 3α-androstanediol was given in combined treatment with oestradiol and progesterone. Given with progesterone, 3α-androstanediol showed a synergistic inhibitory action on FSH release between 20 and 30 days of age. However, when 3α-androstanediol was combined with oestradiol a clear decrease in effect, as compared to the effect of oestradiol alone, was found between 20 and 30 days of age. Also the effect of combined oestradiol and progesterone treatment was greater than the effect of combined treatment with oestradiol, progesterone and 3α-androstanediol. At all ages after day 20 none of the steroid combinations tested was capable of maintaining FSH levels in ovariectomized rats similar to those in intact rats. It is concluded that 3α-androstanediol might play a role in the control of FSH secretion in the immature rat, but after day 20 the potentially inhibitory action of 3α-androstanediol on FSH secretion is limited in the presence of oestradiol.

scholarly journals New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay

2021 ◽  
Vol 43 (1) ◽  
Author(s):  
Kenichi Masumura ◽  
Tomoko Ando ◽  
Akiko Ukai ◽  
Sho Fujiwara ◽  
Shigeo Yokose ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Gene Mutation ◽  
Point Mutations ◽  
Chromosome 1 ◽  
Transgenic Rat ◽  
Target Tissue ◽  
Sequencing Analysis ◽  
Rat Strain ◽  
Packaging Efficiency

Abstract Background Gene mutation assays in transgenic rodents are useful tools to investigate in vivo mutagenicity in a target tissue. Using a lambda EG10 transgene containing reporter genes, gpt delta transgenic mice and rats have been developed to detect point mutations and deletions. The transgene is integrated in the genome and can be rescued through an in vitro packaging reaction. However, the packaging efficiency is lower in gpt delta rats than in mice, because of the transgene in gpt delta rats being heterozygous and in low copy number. To improve the packaging efficiency, we herein describe a newly developed homozygous gpt delta rat strain. Results The new gpt delta rat has a Wistar Hannover background and has been successfully maintained as homozygous for the transgene. The packaging efficiency in the liver was 4 to 8 times higher than that of existing heterozygous F344 gpt delta rats. The frequency of gpt point mutations significantly increased in the liver and bone marrow of N-nitroso-N-ethylurea (ENU)- and benzo[a]pyrene (BaP)-treated rats. Spi− deletion frequencies significantly increased in the liver and bone marrow of BaP-treated rats but not in ENU-treated rats. Whole genome sequencing analysis identified ≥ 30 copies of lambda EG10 transgenes integrated in rat chromosome 1. Conclusions The new homozygous gpt delta rat strain showed a higher packaging efficiency, and could be useful for in vivo gene mutation assays in rats.

Impaired activation of mast cells upon IgE-mediated antigen stimulation in a stroke-prone spontaneously hypertensive rat strain, SHRSP.Z

2010 ◽  
Vol 128 (1) ◽  
pp. 74-79
Author(s):  
Mariko Sakanaka ◽  
Kazuyuki Furuta ◽  
Atsushi Ichikawa ◽  
Satoshi Tanaka
Keyword(s):  
Mast Cells ◽  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Antigen Stimulation ◽  
Hypertensive Rat ◽  
Rat Strain ◽  
Ige Mediated

Induction of proliferative lesions of ventral prostate, seminal vesicle, and other accessory sex glands in rats byN-methyl-N-nitrosourea: Effect of castration, pretreatment with cyproterone acetate and testosterone propionate, and rat strain

The Prostate ◽  
1992 ◽  
Vol 20 (4) ◽  
pp. 339-353 ◽  
Author(s):  
Maarten C. Bosland ◽  
Menk K. Prinsen ◽  
Robert Kroes ◽  
Abraham Rivenson ◽  
Jerrold Silverman ◽  
...  
Keyword(s):  
Seminal Vesicle ◽  
Cyproterone Acetate ◽  
Testosterone Propionate ◽  
Ventral Prostate ◽  
Accessory Sex Glands ◽  
Rat Strain

scholarly journals Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity

2014 ◽  
Vol 210 (4) ◽  
pp. 854-864 ◽  
Author(s):  
M. A. Høydal ◽  
T. O. Stølen ◽  
A. B. Johnsen ◽  
M. Alvez ◽  
D. Catalucci ◽  
...  
Keyword(s):  
Aerobic Capacity ◽  
Ryanodine Receptors ◽  
Rat Strain ◽  
Trigger Arrhythmia
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