scholarly journals Leukotriene D4 Measurement

2020 ◽  
Author(s):  
Keyword(s):  
Leukotriene D4

Unique coronary vasodilator induction by leukotriene D4

1985 ◽  
Vol 249 (3) ◽  
pp. H698-H702 ◽  
Author(s):  
D. Ezra ◽  
G. Feuerstein ◽  
J. F. Czaja ◽  
F. R. Laurindo ◽  
C. K. Finton ◽  
...  
Keyword(s):  
Coronary Flow ◽  
Platelet Rich Plasma ◽  
Platelet Activating Factor ◽  
Adenosine Diphosphate ◽  
Coronary Vein ◽  
Marked Rise ◽  
Leukotriene D4 ◽  
Coronary Vasodilator ◽  
Myocardial Area

Coronary blood flow (CBF) and myocardial contractility decrease markedly in response to intracoronary administration of leukotriene D4 (LTD4). With steady infusion, however, both CBF and contractility escape, approaching preinfusion values despite ongoing LTD4 administration. To clarify the mechanism of this escape, we reinfused plasma from the coronary vein draining the myocardial area receiving LTD4. Introducing this plasma into a coronary artery caused a marked rise in coronary flow for the duration of the plasma infusion. Coronary flow reduction with vasopressin or mechanical occlusion matching that caused by LTD4 failed to elicit vasodilator production. Thus a unique coronary vasodilator factor is induced by LTD4. Whole blood or platelet-rich plasma incubated with LTD4 in vitro produced the same pattern of coronary dilation on intracoronary infusion; LTD4 incubation with platelet-poor plasma failed to elicit a vasodilation. The vasodilator factor is stable and is not potassium, a prostaglandin, catecholamine, histamine, serotonin, adenosine, adenosine diphosphate, or platelet-activating factor. Production of this leukotriene-induced vasodilator factor may account for the escape from LTD4-induced coronary constriction.

Metabolism and cardiovascular effects of leukotrienes in warm- and cold-acclimated American bullfrogs (Rana catesbeiana)

1991 ◽  
Vol 260 (5) ◽  
pp. R834-R838
Author(s):  
C. A. Herman ◽  
G. A. Charlton ◽  
R. L. Cranfill
Keyword(s):  
Time Course ◽  
Rana Catesbeiana ◽  
Cardiovascular Effects ◽  
Leukotriene C4 ◽  
Gamma Glutamyl Transpeptidase ◽  
Leukotriene D4 ◽  
Inactivation Mechanism ◽  
Glutamyl Transpeptidase

Sulfidopeptide leukotrienes are important mediators in mammals, but much less is known of their metabolism and action in nonmammalian vertebrates. This study examines the cardiovascular effects of leukotrienes on blood pressure and heart rate and compares the metabolism of leukotrienes in vivo and in vitro in warm- and cold-acclimated bullfrogs. Leukotriene C4 (LTC4) is more potent than leukotriene D4 (LTD4) and leukotriene E4 (LTE4) in eliciting hypotension. The leukotrienes are more potent in warm-acclimated animals. Conversion of [3H]LTC4 to [3H]LTD4 occurs rapidly in warm-acclimated bullfrogs, with 15.2 +/- 1.7% of the [3H]LTC4 remaining at 1.5 min. Conversion is slower in vivo in cold-acclimated frogs, with 20.2 +/- 1.7% of the [3H]LTC4 remaining by 6 min. In blood taken from warm-acclimated frogs, conversion of [3H]LTC4 to [3H]LTD4 occurs more rapidly at 22 than at 5 degrees C. This pattern is similar in blood taken from cold-acclimated frogs, suggesting that no modification of gamma-glutamyl transpeptidase occurs at low temperature. [3H]LTE4 production is not observed in vivo or in vitro during the time course of the experiments. The rapid metabolism of LTC4 to LTD4 may represent an inactivation mechanism in amphibians. The cardiovascular effects of LTC4 in vivo may be much greater than current measurements indicate because of rapid conversion of LTC4 to the less potent LTD4.

Bronchodilator properties of an inhaled leukotriene D4 antagonist (verlukast—MK-0679) in asthmatic patients

1992 ◽  
Vol 5 (2) ◽  
pp. 121-125 ◽  
Author(s):  
J.-W.J. Lammers ◽  
P. Van Daele ◽  
F.M.J. Van den Elshout ◽  
M. Decramer ◽  
A. Buntinx ◽  
...  
Keyword(s):  
Leukotriene D4 ◽  
Asthmatic Patients

Effects of intra-coronary administration of leukotriene D4 in the anaesthetized dog

1983 ◽  
Vol 26 (4) ◽  
pp. 563-572 ◽  
Author(s):  
L.G. Letts ◽  
D.L. Newman ◽  
S.E. Greenwald ◽  
Priscilla J. Piper
Keyword(s):  
Leukotriene D4 ◽  
Anaesthetized Dog

ChemInform Abstract: SYNTHESIS OF THE 7-CIS ISOMER OF THE NATURAL LEUKOTRIENE D4

1982 ◽  
Vol 13 (19) ◽  
Author(s):  
I. ERNEST ◽  
A. J. MAIN ◽  
R. MENASSE
Keyword(s):  
Leukotriene D4 ◽  
Cis Isomer

Effects of sustained leukotriene D4 administration of myocardial contractility and coronary flow

1984 ◽  
Vol 28 (5) ◽  
pp. 673-674 ◽  
Author(s):  
Robert E. Goldstein ◽  
David Ezra ◽  
Gordon Letts
Keyword(s):  
Myocardial Contractility ◽  
Coronary Flow ◽  
Leukotriene D4

Leukotriene D4 enhances tumor necrosis factor-α-induced vascular endothelial growth factor production in human monocytes/macrophages

Cytokine ◽  
2011 ◽  
Vol 55 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Yasuhiro Haneda ◽  
Shunji Hasegawa ◽  
Reiji Hirano ◽  
Kunio Hashimoto ◽  
Ayami Ohsaki ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Vascular Endothelial ◽  
Human Monocytes ◽  
Leukotriene D4 ◽  
Growth Factor Production ◽  
Factor Α ◽  
Endothelial Growth Factor ◽  
Necrosis Factor

Comparative effects of platelet activating factor, leukotriene D4 and histamine on guinea pig trachea, bronchus and lung parenchyma

1987 ◽  
Vol 33 (2) ◽  
pp. 199-208 ◽  
Author(s):  
S. Jancar ◽  
P. Thériault ◽  
P. Braquet ◽  
P. Sirois
Keyword(s):  
Guinea Pig ◽  
Platelet Activating Factor ◽  
Lung Parenchyma ◽  
Leukotriene D4
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