scholarly journals Hyalinizing clear cell carcinoma of parotid, intricacies of management:a rare case report

2021 ◽  
pp. 171-175

Hyalinizing clear cell carcinoma (HCCC) usually affects minor salivary glands. It rarely occurs in major salivary glands. HCCCis difficult to diagnose in Fine Needle Aspiration cytology (FNAC). The possibility of metastasis from other primary sites should be rejected during the management of these tumors. An elderly manpresented with insidious onset, and gradual progressive painless swelling arising from the deep lobe of the parotid gland. FNAC, which was performedtwice with UltrasoundGuidance(USG), could not provide much detail about the type of tumor. Total conservative parotidectomy was conducted. These rare tumors cause significant challenges to physicians. Thehigh index of suspicion and combined efforts ofthe multidisciplinary team are pivotal in management.

2004 ◽  
Vol 48 (4) ◽  
pp. 560-564 ◽  
Author(s):  
Agustín Vaíllo ◽  
Francisco Javier Rodríguez-Recio ◽  
Antonia Gutiérrez-Martín ◽  
Claudio Ballestín ◽  
Juan Manuel Ruiz-Liso

1998 ◽  
Vol 42 (2) ◽  
pp. 413-418 ◽  
Author(s):  
Fumiko Satoh ◽  
Shinobu Umemura ◽  
Hitoshi Itoh ◽  
Youko Miyajima ◽  
Yutaka Tokuda ◽  
...  

2000 ◽  
Vol 23 (5) ◽  
pp. 333-337 ◽  
Author(s):  
Sara Milchgrub ◽  
Frank Vuitch ◽  
M. Hossein Saboorian ◽  
Arif Hameed ◽  
Horace Wu ◽  
...  

2008 ◽  
Vol 52 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Metin Akbulut ◽  
Osman Zekioglu ◽  
Murat Kapkac ◽  
Yildiz Erhan ◽  
Necmettin Ozdemir

2015 ◽  
Vol 59 (3) ◽  
pp. 239-247 ◽  
Author(s):  
Chung Hun Lee ◽  
Soo Young Chung ◽  
Kyung Chul Moon ◽  
In Ae Park ◽  
Yul Ri Chung ◽  
...  

Objective: Fine-needle aspiration cytology (FNAC) based on a liquid-based preparation is a safe and valuable diagnostic tool. However, due to unfamiliarity with this method and the considerably altered morphology that is associated with it, diagnosing renal cell carcinoma (RCC) from this type of preparation remains a challenge for cytopathologists. The aim of this study was to evaluate the cytomorphological characteristics of SurePath™ (SP)-based preparations compared with conventional smear (CS), and also the role of SP-based FNAC in the diagnosis of clear-cell RCC (CRCC), the most common primary renal malignancy. Study Design: Ex vivo FNAC of both tumors and normal renal parenchyma was prepared from 73 cases. Comparative cytomorphological analysis between liquid-based cytology (LBC) and CS as well as Fuhrman nuclear grading (FNG) was carried out. Immunocytochemistry was performed from normal and CRCC cytology specimens. Results: Normal renal cytology (NRC) showed no significant morphological differences between LBC and CS. For CRCC, LBC showed small, fragmented cell clusters, a 3-dimensional configuration, distinct cytoplasmic vacuoles, and irregular nuclear contours when compared with CS. FNG was overgraded with LBC compared to with CS. AMACR was the most valuable immunocytochemical marker for distinguishing CRCC from NRC. Conclusion: Once cytopathologists become familiar with the altered cytomorphological features of CRCC, FNAC, along with immunocytochemistry, may prove helpful for diagnosis.


2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Takahiro Yamanishi ◽  
Kiwako Kutsuma ◽  
Keisuke Masuyama

Hyalinizing clear cell carcinoma (HCCC), so-called clear cell carcinoma, not otherwise specified (CCC (NOS)), of the salivary glands is a rare and low-grade malignant tumor. We report a case of HCCC so-called CCC (NOS) (referred to as HCCC) of the minor salivary gland of the buccal mucosa. A 52-year-old woman had presented with a gradually growing and indolent mass in the right buccal mucosa for about two years. The first biopsy histopathologically suggested the possibility of malignancy derived from the minor salivary glands. A month later, she visited our hospital. The tumor measured approximately 1.5 cm in diameter and was elastic hard, smooth, and well movable. Image examinations demonstrated internal homogeneity of the lesion, which had a smooth margin, in the right buccal mucosa. Complete tumor resection followed by covering with a polyglycolic acid sheet and fibrin glue spray was performed without surgical flap reconstruction. Histopathological findings revealed proliferating tumor cells with clear cytoplasm surrounded by hyalinizing stroma in the submucosal minor salivary glands. Immunohistochemical stains revealed these tumor cells to be positive for epithelial cell markers but negative for myoepithelial ones. These findings confirmed the diagnosis of HCCC. Good wound healing and no evidence of local recurrence and metastasis have been shown since surgery.


1994 ◽  
Vol 108 (8) ◽  
pp. 716-718 ◽  
Author(s):  
Esa Rajab ◽  
Sharifah Nor Akmal ◽  
Abdul Majid Nasir

AbstractThe case of a minor salivary gland tumour, arising from the tongue, with nodal metastasis is presented. Biopsy of the tumour and fine-needle aspiration cytology of the neck swelling showed the presence of a clear cell carcinoma with evidence of nodal metastases. A commando operation was performed and the defect was reconstructed using a local tongue flap. The literature review indicated that the neoplasm was rare and its site of occurrence rather unusual.


2002 ◽  
Vol 116 (10) ◽  
pp. 851-853 ◽  
Author(s):  
R. Balakrishnan ◽  
Dipak Ranjan Nayak ◽  
Suresh Pillai ◽  
Lakshmi Rao

Clear cell carcinoma of the salivary glands is a rare tumour that represents less than one per cent of all salivary tumours. They are divided into a biphasic, epithelial-myoepithelial carcinoma and a monophasic pattern which may be myoepithelial or ductal in origin. The latter is accompanied by prominent fibrohyaline stroma and has been described recently as hyalinizing clear cell carcinoma (HCCC).Most of the HCCC occur in the oral cavity, and are associated with minor salivary glands, unlike the biphasic pattern which is more common in the major salivary glands. In the oral cavity, the commonest site is the palate followed by the lips and the buccal mucosa. Its occurrence in the oropharynx and the larynx is extremely rare.


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