Synthesis of new chloro derivatives of 1,3-dioxolane and obtaining on them basis load-carrying additives

Abstract This paper gives the results of part of a systematic investigation into contaminant toxicity to Photobacterium phosphoreum in the Microtox™ test. Reported are the toxicity values for 39 para-chloro substituted benzene derivatives of the general formula l-Cl-C6h4-4-X=CH2CH(NH2)COOH, F, SO2NH2, OCH2COOH, CH2COOH, CONHNH2, NHCOCH3, CONH2, CH=CHCOOH, SeOOH, CH2NH2, CH2CH2NH2, NO2, H, CF3, CHO, CH2OH, OH, CH3, CCl3, COCH3, COOH, NH2, SO2C6H5, Cl, CH2COCH3, COCl, CN, OCH3, NCO, NHCH3, I, COC6H5, CH2Cl, SH, CH2SH, NCS, CH2CN and SO2C6H4Cl. Except for the last compound, whose solubility is below the required concentration, the toxicities increase in the presented order with a total range of more than three orders of magnitude. The data are discussed in terms of quantitative structure-toxicity correlations with compound-specific structural parameters. In combination with a previously developed submodel on chlorinated benzenes, phenols, nitrobenzenes and anilines, the observed relationships allow the prediction of the toxicity of some 780 possible chloro derivatives of the general formula C6H5-nClnX, where n=<5 and X is a functional group as listed above.

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Some 6-substituted derivatives of D-8-cyanomethylergoline-I and D-8-methylergoline-I

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19790946 ◽

1979 ◽

Vol 44 (3) ◽

pp. 946-951 ◽

Cited By ~ 4

Author(s):

Antonín Černý ◽

Jiří Křepelka ◽

Miroslav Semonský

Keyword(s):

Inhibiting Activity ◽

Chloro Derivatives ◽

Derivatives Of

Compounds III-XX exhibiting antilactation and antinidation effects in tests on rats were prepared on N(6)-alkylation of D-8-cyanomethylergoline-I (I) or D-8-methylergoline-I (II) with corresponding bromo (chloro) derivatives in dimethylformamide. The most distinct prolactin-inhibiting activity was found in compound III.

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Some 1-substitution derivatives of 4-aryl-2,3-dihalogeno-1-naphthols

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19840110 ◽

1984 ◽

Vol 49 (1) ◽

pp. 110-121 ◽

Cited By ~ 1

Author(s):

Jiří Křepelka ◽

Drahuše Vlčková ◽

Milan Mělka

Keyword(s):

Thionyl Chloride ◽

Oxirane Ring ◽

Secondary Amines ◽

Two Phase ◽

Lytic Effect ◽

Primary And Secondary Amines ◽

Phase Medium ◽

Chloro Derivatives ◽

Derivatives Of

Alkylation of derivatives of 4-aryl-1-naphthols (I-V) by 2,3-epoxypropyl chloride in methanolic sodium hydroxide gave epoxy derivatives VI, VIII, IX, XI and XII, apart from products of cleavage of the oxirane ring, VII and X. Analogous alkylation of compounds I, IV and V by 2-(N,N-diethylamino)ethyl chloride hydrochloride in a two-phase medium afforded basic ethers XIII to XV. The cleavage of the oxirane ring in compound VI by the action of primary and secondary amines, piperidine and substituted piperazines led to compounds XVI-XXIV. Reaction of thionyl chloride with compounds XXI, XXII and XXIV gave chloro derivatives XXV-XXVII.Exposure of compound XXII to 4-methylbenzenesulfonyl chloride produced compound XXVIII, retaining the secondary alcoholic group. In an antineoplastic screening in vivo none of the compounds prepared had an appreciable activity. Compound XVII, being an analogue of propranolol, was used in the test of isoproterenolic tachycardia, and showed a beta-lytic effect comparable with that of propranol.

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Fluorinated tricyclic neuroleptics with prolonged action: 8-Methoxy, 8-ethoxy, 8-ethylthio and 8-hydroxy derivatives of 3-fluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19821382 ◽

1982 ◽

Vol 47 (5) ◽

pp. 1382-1391 ◽

Cited By ~ 2

Author(s):

Jiří Jílek ◽

Josef Pomykáček ◽

Jiřina Metyšová ◽

Miroslav Protiva

Keyword(s):

Acetic Acid ◽

Polyphosphoric Acid ◽

Prolonged Action ◽

Substitution Reactions ◽

Methoxy Derivative ◽

Chloro Derivatives ◽

Boron Tribromide ◽

Derivatives Of ◽

Central Depressant ◽

Boiling Toluene

Acids IIa-c were prepared by reactions of (4-fluoro-2-iodophenyl)acetic acid with 4-methoxythiophenol, 4-ethoxythiophenol and 4-(ethylthio)thiophenol and cyclized with polyphosphoric acid in boiling toluene to dibenzo[b,f]thiepin-10(11H)-ones IIIa-c. Reduction with sodium borohydride afforded the alcohols IVa-c which were treated with hydrogen chloride and gave the chloro derivatives Va-c. Substitution reactions with 1-methylpiperazine resulted in the title compounds Ia-c out of which the methoxy derivative Ia was transformed by demethylation with boron tribromide to the phenol Id. Compounds Ia-d are very potent neuroleptics exhibiting a clear prolongation of the central depressant and some prolongation of the cataleptic activity.

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ChemInform Abstract: NEW CHLORO DERIVATIVES OF BENZOTHIOPYRANOINDOLES AND -QUINOLINES

Chemischer Informationsdienst ◽

10.1002/chin.197640264 ◽

1976 ◽

Vol 7 (40) ◽

pp. no-no

Author(s):

A. FRAVOLINI ◽

A. CROISY ◽

P. JACQUIGNON

Keyword(s):

Chloro Derivatives ◽

Derivatives Of

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Effects of Polysubstitution on Mesomorphic Properties: Chloro Derivatives of 4-Methoxyphenyl 4-(Phenyliminomethyl)-benzoate and Related Compounds

Molecular Crystals and Liquid Crystals ◽

10.1080/00268949108030904 ◽

1991 ◽

Vol 195 (1) ◽

pp. 239-249 ◽

Cited By ~ 15

Author(s):

Y. Matsunaga ◽

K. Yasuhara

Keyword(s):

Chloro Derivatives ◽

Derivatives Of ◽

Related Compounds ◽

Mesomorphic Properties

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Infrared Spectra of Some Chloro Derivatives of s-Triazine

Applied Spectroscopy ◽

10.1366/000370266774386164 ◽

1966 ◽

Vol 20 (3) ◽

pp. 159-160 ◽

Cited By ~ 1

Author(s):

T. S. Herman

Keyword(s):

Infrared Spectra ◽

Triazine Ring ◽

Chlorine Atoms ◽

Vibrational Assignments ◽

Fundamental Frequencies ◽

Bending Mode ◽

Chloro Derivatives ◽

Derivatives Of

The effects of chlorine atoms on the fundamental frequencies of the s-triazine ring are discussed and the vibrational assignments in the region 1600–700 cm−1 are extended. The variation in the position of the C3N3-ring bending mode in the region near 810 cm−1 is discussed.

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