Histolopathological exploration & Morphological changes of thyroid gland with Grave disease

Introduction Potassium iodine (KI) is used as a drug therapy for treating numerous diseases such as small-vessel vasculitis, erythema nodosum, vasculitis nodularis, Sweet's syndrome, tuberculosis and granulomatosis, and for iodized salt. At the same time, KI can be harmful. Iodine intake may increase the frequency of thyroiditis in humans, and may induce the occurrence of experimental thyroiditis (ET) in animals. Investigations on an experimental model for the examination of thyroiditis in Wistar rats have clearly showed morphological changes in the rat thyroid evoked by KI administration. Objective The purpose of this study was to compare the effects of low and high doses of KI on the thyroid gland of Wistar rats and determine the effect on hormone status (T4, T3 and TSH) in this rat strain. Methods Two groups of rats from the Wistar strain were treated with a low iodine dose (225 ?g/g BW) and with a high iodine dose (675 ?g/g BW) of KI solutions. Untreated nonimmunized animals served as controls. The solution was administrated daily intraperitoneally during the period of 26 consecutive days. Results Monitoring hormone status (TSH, T3 and T4) and morphological changes it was found that therapeutic doses of KI applied in treatment induced the occurrence of experimental thyroiditis (chronic destructive Hashimoto's thyroiditis in humans) and cell necrosis in animals not carrying a genetic susceptibility. Significant inflammatory changes were observed in rats treated with a high iodine dose. Conclusion The early iodine induced cell necrosis and inflammation in the nonimmunized animals without genetic susceptibility is a new experimental model of thyroiditis. .

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DYNAMIC MORPHOLOGICAL CHANGES IN THE THYROID GLAND ASSOCIATED WITH DEPLETION OF DEUTERIUM BODY CONTENT

10.47501/978-5-6044060-1-4.18 ◽

2021 ◽

Author(s):

Ekaterina Timokhina ◽

◽

Nataliya Yaglova ◽

Sergey Obernikhin ◽

Valentin Yaglov ◽

...

Keyword(s):

Thyroid Gland ◽

Morphological Changes ◽

Hormone Secretion ◽

Deuterium Content ◽

Thyroid Cells

Dynamics of morphological changes in the thyroid gland of mice, consuming water with lower deuterium content, was studied. Primary changes in structure were indicative of more active hormone secretion. Later morphological signs of inhibited hormone secretion were found. The findings demonstrate sensitivity of thyroid cells to shifts in deuterium body con-tent.

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Lipomatous Metaplasia of the Thyroid Gland: A Clinicopathologic Review

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqz113.012 ◽

2019 ◽

Vol 152 (Supplement_1) ◽

pp. S41-S42

Author(s):

Joanna Solarewicz ◽

Vijaya Reddy ◽

Pincas Bitterman ◽

Ritu Ghai ◽

Paolo Gattuso

Keyword(s):

Thyroid Gland ◽

Papillary Carcinoma ◽

Regional Lymph Node ◽

Thyroid Tissue ◽

Follicular Adenoma ◽

Hashimoto Thyroiditis ◽

Grave Disease ◽

Surgical Pathology ◽

Lipomatous Metaplasia ◽

Thyroid Lesions

Abstract Objectives Lipomatous metaplasia involving the thyroid gland is uncommon in surgical pathology and the majority of published literature is confined to single case reports. We undertook a retrospective study to assess the frequency of fat metaplasia among benign and neoplastic thyroid lesions. Methods Surgical pathology files from 1992 to 2018 at our institution were searched for lipomatous metaplasia involving the thyroid gland. A total of 2,018 cases of thyroid lesions after lobectomy or total thyroidectomy with or without regional lymph node sampling were identified. Patient clinical and pathologic data were reviewed. Results The 2,018 thyroid cases reviewed included 828 papillary carcinomas, 33 medullary carcinomas, 26 anaplastic carcinomas, 25 follicular carcinomas, 262 follicular adenomas, 422 goiters, 373 Hashimoto thyroiditis, and 49 Grave disease. Lipomatous metaplasia was recorded in 17 cases (0.8%), which included 8 males and 9 females with a mean age of 67 years (range: 55 to 82). The most common lesion containing fat metaplasia was goiter (7/422 cases, 1.7%), followed by follicular adenoma (4/262, 1.5%), papillary carcinoma (4/828, 0.5%), Hashimoto thyroiditis (1/373, 0.3%), and Grave disease (1/49, 2%). When associated with papillary carcinoma, lipomatous metaplasia was located in the surrounding benign thyroid tissue in 2/4 cases and in malignant papillary structures metastatic to neck lymph nodes in the remaining 2/4 cases. Conclusion Lipomatous metaplasia of the thyroid gland is a rare phenomenon, present in only 17/2,018 cases (0.8%) in our study. It was more commonly seen in reactive processes (9/844 cases, 1.1%) and follicular adenomas (4/262 cases, 1.5%). Among the 912 cases of malignant tumors, fat metaplasia was only identified in papillary carcinoma (4/828, 0.5%), half of which showed metaplasia at the metastatic site. The presence of lipomatous metaplasia in reactive as well as neoplastic lesions cannot be used as a reliable histologic feature to exclude a neoplastic process.

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Morphological characteristic and assessment of changesin the main structural components of the histohematological barrier of the thyroid tissue in cases of the sudden cardiac death from alcoholic cardiomyopathy

Pediatrician (St Petersburg) ◽

10.17816/ped8530-34 ◽

2017 ◽

Vol 8 (5) ◽

pp. 30-34

Author(s):

Olga V. Sokolova ◽

Orazmurad D. Yagmurov ◽

Ruslan A. Nasyrov

Keyword(s):

Sudden Cardiac Death ◽

Thyroid Gland ◽

Cardiac Death ◽

Morphological Changes ◽

Cytotoxic Action ◽

Structural Components ◽

Alcoholic Cardiomyopathy ◽

Endothelial Lining ◽

Gland Tissue ◽

Thyroid Gland Tissue

A retrospective analysis of acts of forensic medical autopsies from the archive of St. Petersburg GBUS BSME and a histological study of thyroid gland tissue in 188 cases (95 women and 93 men) were carried out with statistical processing of the obtained results for the purpose of studying and assessing the morphological changes in the main components of the histohematological barrier of thyroid gland tissue in cases of the sudden cardiac death from alcoholic cardiomyopathy. The decrease in the weight of the thyroid gland in the investigated cases and the revealed morphological signs, indicative of a decrease in the memory function of the thyroid gland were found and can be caused by the prolonged toxic effect of ethanol and its metabolites. Morphological changes in the endothelial lining of the vessels of the microcirculatory bed are caused both by the direct cytotoxic action of ethanol and its metabolites and by the action of mediators, the release of which occurs as a result of stimulation of the reactive cells, which leads to swelling, deformation and increased activity of endothelial cell membranes with the expansion of intercellular spaces and the development of increased permeability of the endothelial lining, which, in its turn, contributes to disruption of electrolyte transport and nutrients transport with changes trophism thyroid gland tissue, which is a substrate for the appearance of dystrophic and necrobiotic processes in main structural components of the histogematogenous barrier of the thyroid gland. The revealed morphological changes in thyroid gland tissue in cases of death from alcoholic cardiomyopathy have a non-specific nature and should be considered in conjunction with other visceral manifestations that are a reflection of alcohol intoxication during the chronic alcoholism.

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Some morphological changes in the rat thyroid gland during experimental hyperphenylalaninemia

The Anatomical Record ◽

10.1002/(sici)1097-0185(199706)248:2<251::aid-ar12>3.0.co;2-o ◽

1997 ◽

Vol 248 (2) ◽

pp. 251-258 ◽

Cited By ~ 1

Author(s):

V.S. Usenko ◽

I.N. Kornilovskaya ◽

V.V. Lizogubov ◽

E.O. Apostolov ◽

E.A. Gubkina ◽

...

Keyword(s):

Thyroid Gland ◽

Morphological Changes ◽

Rat Thyroid ◽

Rat Thyroid Gland

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Effects of sulfonamide on the pituitary-thyroid gland. 2. Morphological changes of thyrotrophs in anterior pituitary gland.

The Journal of Toxicological Sciences ◽

10.2131/jts.8.61 ◽

1983 ◽

Vol 8 (1) ◽

pp. 61-70 ◽

Cited By ~ 2

Author(s):

Satoshi NISHIKAWA

Keyword(s):

Thyroid Gland ◽

Pituitary Gland ◽

Anterior Pituitary ◽

Morphological Changes ◽

Anterior Pituitary Gland

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The case of histiocytosis X (Hand - Schüller – Christian disease) with thyroid gland lesion

Problems of Endocrinology ◽

10.14341/probl12040 ◽

1996 ◽

Vol 42 (3) ◽

pp. 26-29

Author(s):

M. E. Bronstein ◽

G. A. Melnichenko ◽

A. I. Bukhman ◽

T. A. Starostina ◽

O. L. Ivanov ◽

...

Keyword(s):

Thyroid Gland ◽

Rare Disease ◽

Clinical Manifestation ◽

Clinical Picture ◽

Langerhans Cells ◽

Morphological Changes ◽

Eosinophilic Granuloma ◽

Biological Significance ◽

Histiocytosis X ◽

Mutual Transition

Histiocytosis X, which is a rare disease, combines 3 related but different in clinical manifestation, course and prognosis of the syndrome: eosinophilic granuloma (Taratynovs disease), Hand Schller Christian disease (syndrome) and Letterer Siw disease (syndrome). The clinical picture of Hend Schller Christian disease was first described by Hand in 1893, then by Schller in 1915 and Christian in 1920. The term histiocytosis X was first proposed in 1953 by Liechtenstein, who combined all 3 of the aforementioned diseases under this name. on the basis of the similarity of the clinical picture, the possibility of a mutual transition from one state to another and typical morphological manifestations consisting in the proliferation of histiocytes and the accumulation of various lipids in their cytoplasm. In 1965, this concept was confirmed in all three diseases, there are no special pentalaminar markers in the cytoplasm of histiocytes that are detected in Langerhans cells (hence the name of these inclusions - "Langerhans cell granules"), the origin and biological significance of which remains unclear. Histiocytes have no signs of atypia, although they infiltrate many organs and tissues retain their normal properties. Histiocytic proliferation can develop in various organs and tissues, causing them to corresponding functional and morphological changes.

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Morphological changes in the thyroid gland of rats after magnesium chloride ingestion

CLINICAL AND EXPERIMENTAL MORPHOLOGY ◽

10.31088/cem2019.8.3.41-47 ◽

2019 ◽

Vol 8 (3) ◽

pp. 41-47

Author(s):

R.V. Yanko ◽

◽

E.G. Chaka ◽

M.I. Levashov ◽

◽

...

Keyword(s):

Thyroid Gland ◽

Magnesium Chloride ◽

Morphological Changes

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Sonographic assessment of thyroid gland in patients with chronic kidney disease undergoing hemodialysis

International Journal of Diagnostic Imaging ◽

10.5430/ijdi.v5n1p4 ◽

2017 ◽

Vol 5 (1) ◽

pp. 4 ◽

Cited By ~ 1

Author(s):

Maisa Elzakil ◽

Awadia Gareeballah ◽

Moawia Gameraddin ◽

Mowada Burai ◽

Fathelrehman Alagab

Keyword(s):

Chronic Kidney Disease ◽

Thyroid Gland ◽

Kidney Disease ◽

Thyroid Nodules ◽

Kidney Diseases ◽

Morphological Changes ◽

Thyroid Tissue ◽

Thyroid Volume ◽

Cross Sectional Study ◽

Cross Sectional

Background: Thyroid gland morphology and disorders were affected with chronic kidney diseases (CKD). The study aims to assess thyroid gland disorders and morphology in patients with CKD on regular hemodialysis.Materials and methods: A cross-sectional study included 71 participants divided into two groups. The study group included 51 patients with known chronic kidney disease on hemodialysis and healthy group included 20 participants. The exclusion criteria were thyroid disorders. The thyroid gland was scanned with ultrasound using a 7 MHz probe.Results: The thyroid is enlarged in 21.57% of patients and heterogeneous echotexture in 31.4%. The prevalence of thyroid nodules and cysts were 9.8% and 7.8% respectively. A positive linear correlation existed between duration of hemodialysis and thyroid volume. Thyroid volume and echotexture were significantly increased with duration of hemodialysis (p = .001 and .00 respectively). Thyroid nodules and cysts were not significantly correlated with duration of hemodialysis (p = .06 and .28 respectively).Conclusions: In conclusion, enlargement of thyroid gland and heterogeneity of thyroid tissue were the most common morphological changes in patients with chronic renal failure undergoing hemodialysis. The prevalence increased with longer duration of hemodialysis. Periodic ultrasound assessment of thyroid volume and texture are recommended in hemodialyzed patients to avoid complications.

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