Lipomatous Metaplasia of the Thyroid Gland: A Clinicopathologic Review

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S41-S42
Author(s):  
Joanna Solarewicz ◽  
Vijaya Reddy ◽  
Pincas Bitterman ◽  
Ritu Ghai ◽  
Paolo Gattuso
Keyword(s):  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
Regional Lymph Node ◽  
Thyroid Tissue ◽  
Follicular Adenoma ◽  
Hashimoto Thyroiditis ◽  
Grave Disease ◽  
Surgical Pathology ◽  
Lipomatous Metaplasia ◽  
Thyroid Lesions

Abstract Objectives Lipomatous metaplasia involving the thyroid gland is uncommon in surgical pathology and the majority of published literature is confined to single case reports. We undertook a retrospective study to assess the frequency of fat metaplasia among benign and neoplastic thyroid lesions. Methods Surgical pathology files from 1992 to 2018 at our institution were searched for lipomatous metaplasia involving the thyroid gland. A total of 2,018 cases of thyroid lesions after lobectomy or total thyroidectomy with or without regional lymph node sampling were identified. Patient clinical and pathologic data were reviewed. Results The 2,018 thyroid cases reviewed included 828 papillary carcinomas, 33 medullary carcinomas, 26 anaplastic carcinomas, 25 follicular carcinomas, 262 follicular adenomas, 422 goiters, 373 Hashimoto thyroiditis, and 49 Grave disease. Lipomatous metaplasia was recorded in 17 cases (0.8%), which included 8 males and 9 females with a mean age of 67 years (range: 55 to 82). The most common lesion containing fat metaplasia was goiter (7/422 cases, 1.7%), followed by follicular adenoma (4/262, 1.5%), papillary carcinoma (4/828, 0.5%), Hashimoto thyroiditis (1/373, 0.3%), and Grave disease (1/49, 2%). When associated with papillary carcinoma, lipomatous metaplasia was located in the surrounding benign thyroid tissue in 2/4 cases and in malignant papillary structures metastatic to neck lymph nodes in the remaining 2/4 cases. Conclusion Lipomatous metaplasia of the thyroid gland is a rare phenomenon, present in only 17/2,018 cases (0.8%) in our study. It was more commonly seen in reactive processes (9/844 cases, 1.1%) and follicular adenomas (4/262 cases, 1.5%). Among the 912 cases of malignant tumors, fat metaplasia was only identified in papillary carcinoma (4/828, 0.5%), half of which showed metaplasia at the metastatic site. The presence of lipomatous metaplasia in reactive as well as neoplastic lesions cannot be used as a reliable histologic feature to exclude a neoplastic process.

scholarly journals Histomorphologic spectrum of thyroid lesions in surgically treated thyroid specimens

2019 ◽  
Vol 10 (1) ◽  
pp. 54-59
Author(s):  
Wasim Selimul Haque ◽  
Shamoli Yasmin ◽  
SK Md Jaynul Islam ◽  
Susane Giti
Keyword(s):  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
Follicular Adenoma ◽  
Nodular Goiter ◽  
Follicular Carcinoma ◽  
Anaplastic Carcinoma ◽  
Malignant Neoplasms ◽  
Histopathological Diagnosis ◽  
Thyroid Lesion ◽  
Thyroid Lesions

Background: Diseases involving thyroid gland are myriad- they span from functional to goiterous which again can be non-neoplastic or neoplastic. The pattern and prevalence of these disorders depend on various factors like age, sex, ethnicity and geographic location of residence. The aim of the present study was to determine the pattern of thyroid lesions in surgically resected thyroid specimens. Methods: This retrospective study was conducted at Department of Histopathology ofArmed Forces Institute of Pathology (AFIP), Dhaka, Bangladesh. All thyroidectomy specimens received in the Department of Histopathology over the period from 1st January 2018 to 30th June 2019 were included in the study. Data including age, sex and histopathological diagnosis were collected from the records and histopathology slides of all cases were reviewed to verify diagnosis. Data were then analyzed by standard statistical methods. Results: A total of 377 specimens were collected, 301 specimens were from females and 76 from males (female to male ratio 4.01:1). The age ranged from 13 years to 82 years (mean 38.44±12.89 years). Nodular goiter (274, 72.62%) was the commonest thyroid lesion; other benign lesions included follicular adenoma (18) and Hashimoto thyroiditis (17). Overall malignancy was 18.03% (68). Papillary carcinoma (61, 89.70%) constituted majority of the malignant neoplasms. Other malignant neoplasms included follicular carcinoma (3 cases including 1 case of Hurthle cell carcinoma), anaplastic carcinoma (2) and medullary carcinoma and non-Hodgkin lymphoma 1 each. Conclusion: Our study revealed that the prevalent form of thyroid diseases is nodular goiter that mostly affects females. Papillary carcinoma is the commonest malignancy of thyroid gland which also predominantly affects females. Birdem Med J 2020; 10(1): 54-59

Follicular adenoma in a juxtathyroidal thyroglossal duct cyst with papillary carcinoma in the adjacent thyroid gland

2005 ◽  
Vol 26 (5) ◽  
pp. 348-350 ◽  
Author(s):  
William J. Kim ◽  
Raphaelle Souillard ◽  
Margaret S. Brandwein ◽  
William Lawson ◽  
Peter M. Som
Keyword(s):  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
Follicular Adenoma ◽  
Thyroglossal Duct Cyst ◽  
Duct Cyst ◽  
Thyroglossal Duct

Papillary thyroid carcinoma in a lateral neck cyst: primary of ectopic thyroid tissue versus cystic metastasis

2013 ◽  
Vol 127 (7) ◽  
pp. 724-727 ◽  
Author(s):  
J J Xu ◽  
K Kwan ◽  
K Fung
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Gland ◽  
Thyroid Carcinoma ◽  
Papillary Carcinoma ◽  
Thyroid Tissue ◽  
Ectopic Thyroid ◽  
Cystic Degeneration ◽  
Lateral Neck ◽  
Papillary Thyroid ◽  
Ectopic Thyroid Tissue

AbstractObjective:To review the diagnosis of primary papillary carcinoma of ectopic thyroid tissue within branchial cleft cysts, and to discuss the diagnostic challenge of differentiating this condition from metastatic disease when an occult microcarcinoma is found in the thyroid gland.Methods:These comprise a case report and a literature review. We present the case of a 75-year-old woman with papillary thyroid carcinoma within the wall of a recurrent, 15 cm, lateral neck cyst.Results:Histological examination of the patient's thyroid gland found a 0.5 mm papillary thyroid microcarcinoma.Conclusion:Our differential diagnosis was primary papillary carcinoma arising from ectopic thyroid tissue, or metastatic cystic degeneration of a lateral lymph node. We make an argument for the former.

Papillary carcinoma arising in subhyoid ectopic thyroid gland with no orthotopic thyroid tissue

2010 ◽  
Vol 200 (1) ◽  
pp. e17-e18 ◽  
Author(s):  
Ali Ibrahim Sevinç ◽  
Tarkan Unek ◽  
Aras Emre Canda ◽  
Merih Guray ◽  
Mehmet Ali Kocdor ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
Thyroid Tissue ◽  
Ectopic Thyroid

scholarly journals Histomorphological Patterns of Lesions in Thyroid Specimens

2020 ◽  
Vol 24 (1) ◽  
pp. 46-51
Author(s):  
Kainaat Ali ◽  
Sidra Bibi ◽  
Aasiya Niazi
Keyword(s):  
Thyroid Gland ◽  
Follicular Adenoma ◽  
Malignant Neoplasm ◽  
Inflammatory Lesion ◽  
Benign Neoplasm ◽  
Hashimoto Thyroiditis ◽  
Cross Sectional Study ◽  
Thyroid Disorders ◽  
Neck Swelling ◽  
Cross Sectional

Background: The thyroid gland is an important endocrine organ required for the regulation of the basal metabolic rate. It also plays a very important role in growth. Thyroid disorders have great importance because most thyroid diseases are curable. In any area, thyroid gland disorders have a variable incidence and prevalence depending upon several factors. The objective of the study is to find out the relation of age and gender with the frequency of various thyroid lesions.Materials & Methods: It was a descriptive, cross-sectional study carried out on thyroidectomy specimens received at the histopathology laboratory of Holy Family Hospital, Rawalpindi. From January 2015 to June 2018, 242 thyroidectomy specimens were selected based on non-probability consecutive sampling. Reports with no clear-cut definitive diagnosis were excluded. Data were analyzed using SPSS 22.Results: In our study of 242 thyroidectomy specimens, patients' age ranged from 4 to 70 years. 40 to 49 years was the peak age and the mean age was 37.1 years. The female to male ratio was 6.4:1. Of 242 cases, 18(7.4%) were neoplastic thyroid lesions and 224(92.6%) were non-neoplastic ones. Hyperplastic lesions were the most common in our study. The frequency of the inflammatory lesion was 4.1% with Hashimoto thyroiditis (80%) being the most common. The frequency of benign neoplasm was 2.1%. A follicular adenoma was the only benign thyroid neoplasm in our study. The frequency of malignant neoplasm was 5.4%. The most common subtype of thyroid malignancy was papillary thyroid carcinoma (76.9% of the malignant cases). Among a total of 242 cases, 83.1%(n=201) patients had only one presenting complaint (neck swelling). Conclusion: Thyroid disorders are more common in females compared to males. The hyperplastic lesion is the most common type seen. In this study, the most common benign neoplasm is follicular adenoma and the most common malignant neoplasm is papillary carcinoma. Neck swelling is the commonest presenting complaint in our study participants.

scholarly journals Histopathological analysis of thyroid lesions: an institutional experience

2018 ◽  
Vol 5 (5) ◽  
pp. 1217
Author(s):  
Sheela K. M. ◽  
Sreedevi A. R.
Keyword(s):  
Benign Lesion ◽  
Malignant Lesion ◽  
Follicular Adenoma ◽  
Thyroid Neoplasms ◽  
Hashimoto Thyroiditis ◽  
Histopathological Analysis ◽  
Endocrine Disorders ◽  
Female Predominance ◽  
Neoplastic Lesions ◽  
Thyroid Lesions

Background: Diseases of thyroid are one of the most common endocrine disorders affecting general population which range from non-neoplastic to neoplastic lesions. The incidence and pattern of thyroid lesions depend on various factors which include sex, age, ethnic and geographical patterns. Majority of thyroid lesions are non-neoplastic only <5% are malignant. The aim of the present study was to determine the frequency and histomorphological pattern of thyroidectomy specimens and their relationship with age and sex of the patient.Methods: This retrospective study was conducted in the department of pathology, Govt. Medical College, Alappuzha for a period of 2 years. The study included 620 thyroidectomy specimens received in the Department of Pathology. All the biopsy reports were reviewed, and different lesions were categorised according to age and gender distribution. The data was analysed by standard statistical methods.Results: The commonest of the non-neoplastic lesions was nodular colloid goiter followed by lymphocytic thyroiditis, Hashimoto thyroiditis Nodular hyperplasia and thyroglossal cyst. Most common malignant lesion in this study is papillary carcinoma and benign lesion is follicular adenoma. Age group of patients ranged from 6 ½ to 84 years. The study showed a female predominance of 88.38%.Conclusions: Thyroid disorders are commonly encountered endocrine diseases. The study showed a female predominance. Peak age of incidence of thyroid lesions was between 40 and 50 years. Most common lesion was follicular adenoma and most common malignant lesion was papillary carcinoma.Histopathological examination is the mainstay for definite diagnosis and management of thyroid neoplasms.

scholarly journals Histopathological Spectrum of Non-Neoplastic and Neoplastic Lesions of Thyroid: A Descriptive Cross-sectional Study

2020 ◽  
Vol 58 (231) ◽  
Author(s):  
Dilasma Ghartimagar ◽  
Arnab Ghosh ◽  
Manish Kiran Shrestha ◽  
Sushma Thapa ◽  
Om Prakash Talwar
Keyword(s):  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
Follicular Carcinoma ◽  
Cross Sectional Study ◽  
Anaplastic Carcinoma ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Neoplastic Lesions ◽  
Thyroid Lesions

Introduction: Thyroid gland lesions are the most common endocrine disorders encountered globally. Diseases of the thyroid gland present with either an alteration of hormone secretion or as an enlargement of the thyroid gland. The objective of the study is to find the frequency of different thyroid lesions. Methods: A descriptive cross-sectional study was conducted at Manipal Teaching Hospital, Pokhara from Jan 2005 to Jan 2020. Ethical approval was taken from the Institutional Review Committee (Ref: 330). Patients who had undergone thyroidectomy procedures for both non-neoplastic and neoplastic thyroid lesions were enrolled. Convenient sampling was done. IBM Statistical Package for Social Sciences version 21 and Microsoft Excel were used. Results: Out of 345 thyroidectomy specimens, 246 (71.3%) cases of non-neoplastic lesions, and 99 (28.69%) cases of neoplastic lesions were present. There were 54 males and 291 females with a male to female ratio of 1:5.4. The age ranged from 9 to 76 years with a mean age of 43.67 years. In non-neoplastic lesions, the predominant lesion was the colloid goiter with 205 (83.33%) cases followed by Grave’s disease and lymphocytic thyroiditis with 14 (5.69%) cases each. In neoplastic lesions, papillary carcinoma was the commonest lesion with 56 (56.56%) cases followed by follicular carcinoma with 14 (14.14%) cases and follicular adenoma with 13 (13.13%) cases. There were also 9 (9.09%) cases of anaplastic carcinoma in neoplastic lesions. Conclusions: Colloid goiter and papillary carcinoma was the most commonly encountered non-neoplastic and neoplastic lesion with a female predominance. Rare tumors like anaplastic carcinoma, papillary carcinoma, and follicular carcinoma with anaplastic transformation were also encountered.

Massive lateral neck mass: aberrant ectopic thyroid malignancy

2021 ◽  
Vol 14 (5) ◽  
pp. e241451
Author(s):  
Vartika Singh ◽  
Teerthanath Srinivas ◽  
Shubha Bhat ◽  
Shreya Goel
Keyword(s):  
Soft Tissue ◽  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
Thyroid Tissue ◽  
Ectopic Thyroid ◽  
Metastatic Tumour ◽  
Soft Tissue Tumour ◽  
Ectopic Thyroid Tissue ◽  
Tissue Tumour ◽  
Radioiodine Ablation

Lateral aberrant ectopic thyroid is very rare, comprising only 1%–3% of all the ectopic thyroid tissue. Clinically, these lesions are mistaken for lymph node swelling or metastatic tumour. Primary carcinoma in lateral aberrant ectopic thyroid with normal active native thyroid is very uncommon. We report a case of papillary carcinoma in lateral aberrant ectopic thyroid tissue, with a completely normal native thyroid gland in a 53-year-old man, who presented with a massive swelling in the lateral aspect of the neck clinically and radiologically diagnosed as a malignant soft tissue tumour with differential diagnosis of malignant lymphoma. Fine needle aspiration cytology revealed metastatic papillary carcinoma. In toto excision of the soft tissue mass along with subtotal thyroidectomy was performed. Histology of the mass revealed papillary carcinoma of lateral aberrant ectopic thyroid, while the thyroid gland did not show evidence of malignancy. The postsurgical period was uneventful, and the patient underwent radioiodine ablation.

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