Dual Reactivity of the Alkaloid Thebaine and Its Derivatives Towards Acetylenes and the Synthetic Potential Thereof
Keyword(s):
A unique diene moiety of the alkaloid thebaine enables its successful application in the Diels–Alder reaction with ethylene derivatives for producing the adducts that can serve as precursors for a whole class of opioids used in medicine. The interaction of thebaine with acetylenes as an alternative approach to analogous adducts that offers an additional opportunity for their functionalization has received undeservedly little attention. The current review is devoted to these reactions and their synthetic potential.
2020 ◽
2016 ◽
Vol 20
(22)
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pp. 2421-2442
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2014 ◽
Vol 18
(12)
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pp. 1586-1620
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2018 ◽
Vol 15
(2)
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pp. 221-229
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1986 ◽
Vol 51
(5)
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pp. 1083-1085
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2008 ◽
Vol 73
(12)
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pp. 1764-1776
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