scholarly journals Biological Evaluation of Quaternary bis Ammonium Salt and Cetylpyridinum Bromide Against S. epidermidis biofilm

2013 ◽  
Vol 62 (4) ◽  
pp. 359-364
Author(s):  
Justyna Stefańska ◽  
Anna Pietruczuk-Padzik ◽  
Marta Struga ◽  
Maciej Borkowski ◽  
Stefan Tyski
Keyword(s):  
Ammonium Salt ◽  
Broad Spectrum ◽  
Quaternary Ammonium ◽  
Biological Evaluation ◽  
Quaternary Ammonium Compounds ◽  
Quaternary Ammonium Salts ◽  
Bacterial Biofilm ◽  
Ammonium Salts ◽  
Ammonium Compounds

Quaternary ammonium compounds are broad-spectrum bacteriocides widely used as antiseptics, disinfection and preservation agents. The aim of this study was to examine the activity of two quaternary ammonium salts, cetylpyridinum bromide and a newly synthesized quaternary bis ammonium salt, against S. epidermidis biofilm. The average values of killing efficiency for cetylpyridinum bromide ranged from 26.6% to 64.1% for all tested concentrations (0.125 to 8.0 microg x mL(-1)) and for quaternary bis ammonium salt the percentage of killing efficiency ranged from 59.7% to 88.4% for tested concentrations (from 2.0 to 128.0 microg x mL(-1)). Both tested compounds significantly affect staphylococcal biofilms, but any of used concentrations caused a total eradication of bacterial biofilm.

scholarly journals Design of chiral urea-quaternary ammonium salt hybrid catalysts for asymmetric reactions of glycine Schiff bases

RSC Advances ◽  
2015 ◽  
Vol 5 (96) ◽  
pp. 78941-78949 ◽  
Author(s):  
Maximilian Tiffner ◽  
Johanna Novacek ◽  
Alfonso Busillo ◽  
Katharina Gratzer ◽  
Antonio Massa ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Quaternary Ammonium Salts ◽  
Asymmetric Reactions ◽  
Ammonium Salts ◽  
Hybrid Catalysts

Bifunctional chiral urea-containing quaternary ammonium salts can be straightforwardly synthesised and systematically fine-tuned for asymmetric reactions of glycine Schiff bases.

Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer

2020 ◽  
Vol 30 (4) ◽  
pp. 424-426
Author(s):  
Anatoly N. Vereshchagin ◽  
Nikita A. Frolov ◽  
Valeria Yu. Konyuhova ◽  
Evgeniya O. Dorofeeva ◽  
Karl A. Hansford ◽  
...  
Keyword(s):  
Quaternary Ammonium ◽  
Biological Evaluation ◽  
Quaternary Ammonium Compounds ◽  
Synthesis And Biological Evaluation ◽  
Ammonium Compounds

Syntheses of Selected Quaternary Phenacylbromopyridinium Compounds and their Biological Evaluation

1999 ◽  
Vol 54 (9) ◽  
pp. 1210-1218 ◽  
Author(s):  
Khalid M. Khan ◽  
Zafar S. Saifyb ◽  
Abdullah Khan ◽  
Mansoor Ahmed ◽  
Muhammed Saeed ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Quaternary Ammonium ◽  
Parent Compound ◽  
Artemia Salina ◽  
Biological Evaluation ◽  
Quaternary Ammonium Salts ◽  
Biologically Active ◽  
Ammonium Salts ◽  
Antibacterial And Antifungal Activities ◽  
Arterial Blood

The studies, presented here, deal with the synthetic modification of 5-bromonicotinic acid on its nitrogen nucleus. The synthetic transformations were carried out by reacting equimolar amounts of 5-bromonicotinic acid and phenacyl halides in acetone. A range of phenacyl halides were used with the objective of getting a variety of quaternary ammonium salts of 5- bromonicotinic acid derivatives as multipurpose biologically active compounds. Twelve quaternary ammonium salts of 5-bromonicotinic acid have been synthesized and tested for cytotoxicity, antibacterial and antifungal activities. These compounds showed promising cytotoxicity against Artemia salina. Two compounds, 3-carboxy-1-(4′-methylphenacyl)-5-bromopyridinium bromide (2) and 3-carboxy-1-(4′-nitrophenacyl)-5-bromopyridinium bromide (12), were highly active against Gram-positive and Gram-negative bacteria among all the tested compounds. All the compounds were examined for antifungal activity against fifteen fungal cultures, but none of these compounds proved to be effective against these fungi. The parent compounds and its derivatives were also examined for their effect on mean arterial blood pressure in anaesthetized rats. Compounds 7 and 8 were found to be twofold more active than the parent compound. The rest of the products showed blood pressure lowering effects comparable to the parent compound. All compounds were characterised via elemental analysis UV, IR , mass and 1H NMR spectroscopy.

Strategies for the Synthesis of N-Arylammonium Salts

Synthesis ◽  
2017 ◽  
Vol 49 (16) ◽  
pp. 3535-3545 ◽  
Author(s):  
Charles Diesendruck ◽  
Shlomy Arava
Keyword(s):  
Organic Chemistry ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Tertiary Amines ◽  
Pyrylium Salts ◽  
Menshutkin Reaction ◽  
Nucleophilic Aromatic Substitutions ◽  
Ammonium Compounds ◽  
General Method

The N-arylation of tertiary amines to provide sp3 quaternary ammonium salts is a challenge in organic chemistry. To date, no general method for such arylations has been established. Here, we summarize a variety of strategies that have been tested, starting with harsh nucleophilic aromatic substitutions, through to the use of copper catalysis and the application of strong electrophiles, such as phenyl cations and benzynes. The achievements and limitations of each method are summarized, and the challenges yet to be met in the synthesis of charged ammonium compounds are described.1 Introduction2 Alkylation of Anilines: The Menshutkin Reaction3 Arylations3.1 Nucleophilic Aromatic Substitutions by Tertiary Amines3.2 Preparation of N-Arylpyridinum Salts from Zincke and Pyrylium Salts3.3 Arylations Using Phenyl Cations3.4 Copper-Catalyzed Arylation of N-Heteroarenes3.5 Benzynes as Aryl Electrophiles4 Conclusions and Perspective

Synthesis and Characterizaion of Adamantane-Containing Quaternary Ammonium Salts

2011 ◽  
Vol 233-235 ◽  
pp. 238-241 ◽  
Author(s):  
Jian Wei Guo ◽  
Nian Yun Guan ◽  
Sa Liu ◽  
Chu Fen Yang ◽  
Le Jie Zhu
Keyword(s):  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Alkylating Agents ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Adamantane Derivatives ◽  
H Nmr ◽  
Potential Use

To develop the potential use of adamantane derivatives in surfactant field, the adamantyl residue was introduced into the quaternary ammonium salt. The method involved synthesizing N-(1-adamantyl)-N, N-dimethylamine from 1-adamantine and quaternizing with different alkylating agents. Eight adamantane-containing quaternary ammonium salts were prepared and their structures were identified by1H NMR and IR.

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