scholarly journals A Pilot Study of Making New Skin and Appendages for Post Burn Scars through a Unique Cocktail of Platelet Rich Plasma, Ablative Pixel Erbium: Yag Laser and Micro Needling Radiofrequency

2018 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Platelet Rich Plasma ◽  
Hair Follicles ◽  
Assessment Scale ◽  
Plasma Therapy ◽  
Burn Scar ◽  
Yag Laser ◽  
Mean Values ◽  
Scar Assessment ◽  
Maximum Improvement ◽  
New Skin

Burn scars are one of the most resistant and disfiguring scars to be treated by cosmetic and plastic surgery. The challenge remains not only with the damaged top layer but also with singeing and ablation of underlying appendages, vessels, nerves and glandular tissues depending upon the depth and degree of burns. Aim: To improve structural and cosmetic outcome of a burn scar with a cocktail of platelet rich plasma therapy, ablative Pixel Erbium: YAG laser and micro needling. Methods: Five patients of post burn scars were selected for a cocktail treatment of pixel Erbium: YAG laser(Alma lasers, Harmony Platform; 1300mj/p, 5 passes), micro needling radiofrequency (De age: 3mm depth at 35w output, 3 passes) and platelet rich plasma therapy (Two Renew cell kits containing total 27 ml of whole blood). Micro needling radiofrequency was done first followed by instillation of platelet rich plasma (.05ml at a gap of 0.5 cm) each through insulin syringe and ablative laser was done last of all under local anesthesia cream. The sessions were repeated every three weeks for total 3 sessions. Results: There were 2 males and 3 females with post burns scars and all 5 patients completed the study. The scars were assessed using the POSAS (Patient and Observer Scar Assessment Scale). All patients were assessed for the improvement in pigmentation, vascularity, relief in terms of skin texture, thickness, pliability in a scale of 0-10 and also for the appearance of hair follicles (yes/ no). Maximum improvement of 3.8 points was noted in mean values of pigmentation, while thickness and vascularity showed a difference of 1.4 points each in the mean value. The values obtained in Patient Scar Assessment Scale based on the questionnaire are maximum improvement of 4.2 points was seen in mean values of Colour, while mean values of Pain showed improvement of 1.2 points. There was appearance of new hair follicles in 4 out of 5 patients. Conclusion: Platelet rich plasma cocktail can help in creating new skin by resurfacing old scarred skin, rejuvenating dermis and sub cutis, activating dormant hair follicles and forming new vessels and nerves by repairing damaged appendages.

Predictive validity of short term scar quality on final burn scar outcome using the Patient and Observer Scar Assessment Scale in patients with minor to moderate burn severity

Burns ◽  
2017 ◽  
Vol 43 (4) ◽  
pp. 715-723 ◽  
Author(s):  
H. Goei ◽  
C.H. van der Vlies ◽  
W.E. Tuinebreijer ◽  
P.P.M. van Zuijlen ◽  
E. Middelkoop ◽  
...  
Keyword(s):  
Predictive Validity ◽  
Assessment Scale ◽  
Burn Severity ◽  
Short Term ◽  
Burn Scar ◽  
Scar Assessment ◽  
Scar Quality

Burn Scar Evaluation Using the Cutometer® MPA 580 in Comparison to “Patient and Observer Scar Assessment Scale” and “Vancouver Scar Scale”

2017 ◽  
Vol 39 (4) ◽  
pp. 516-526 ◽  
Author(s):  
Marc Nicolai Busche ◽  
Alice-Caroline Johanna Thraen ◽  
Andreas Gohritz ◽  
Hans-Oliver Rennekampff ◽  
Peter Maria Vogt
Keyword(s):  
Assessment Scale ◽  
Burn Scar ◽  
Scar Assessment

scholarly journals Morphological substantiation of clinical efficacy of platelet rich plasma in males with androgenic alopecia

2018 ◽  
Vol 20 (3) ◽  
pp. 67-71
Author(s):  
E E Pakhomova ◽  
I O Smirnova ◽  
I N Telichko
Keyword(s):  
Clinical Efficacy ◽  
Growth Parameters ◽  
Platelet Rich Plasma ◽  
Hair Follicles ◽  
Androgenetic Alopecia ◽  
Sweat Glands ◽  
Androgenic Alopecia ◽  
Hair Density ◽  
Plasma Therapy ◽  
Four Levels

Morphological substantiation of the clinical efficacy of platelets rich plasma was carried out in the treatment of 22 men with androgenetic alopecia from the 1st to the 4th stage according to the Norwood-Hamilton scale were included. All patients received intradermal injections of platelets rich plasma 0,15 ml per injection. The course of treatment consisted of 4 procedures with an interval of 4 weeks. Clinical efficacy was assessed by the dynamics of morphometric indices of hair growth. Histological examination was carried out on horizontal sections, stained with hematoxylin and eosin, the morphology of the hair was counted at four levels. Evaluation of morphometric growth parameters conducted before treatment and 4 months after the onset of it. It was established that the therapy of platelet-rich plasma has a pronounced clinical efficacy, consisting in a significant (p=0,00025) increase in hair density by 11% and average hair diameter by 10% (p=0,00766), a 14% decrease in the share of hair follicles (p=0,00959). Histologically, the increase in hair density was significant at the level of the bulb of the hair follicles by 148% (p=0,0034) and at the level of the sweat glands by 65% (p=0,0326), and also by the tendency to increase their number at the level of the sebaceous glands. This was combined with a significant decrease in the proportion of telogen hair at 47% (p=0,0153). Thus, the positive clinical effect of plasma-rich plasma therapy in men suffering from androgenetic alopecia is based on reliable morphofunctional changes in the hair follicles.

Antiheparin Activity of Human Serum and Platelet Factor 4

1973 ◽  
Vol 30 (01) ◽  
pp. 093-105 ◽  
Author(s):  
C.H.J Sear ◽  
L Poller ◽  
F.R.C Path
Keyword(s):  
Molecular Weight ◽  
Ionic Strength ◽  
Blood Serum ◽  
Whole Blood ◽  
Platelet Rich Plasma ◽  
Gel Filtration ◽  
Normal Serum ◽  
Platelet Factor ◽  
Mean Values ◽  
Antiheparin Activity

SummaryThe antiheparin activity of normal serum has been studied by comparing the antiheparin activities of sera obtained from normal whole blood, platelet-rich plasma and platelet-’free’ plasma with a purified platelet extract during differential isoelectric precipitation and by gel filtration chromatography.The mean values for the activity of PRP-serum and PFP-serum were 106% (S.D. 11) and 10% (S.D. 3) of untreated whole blood respectively. The activity of whole blood serum, PRP serum and whole blood serum plus platelet extract precipitated under identical physical conditions, i.e. pH 7.0, I =0.008, indicating that the activities of the three samples are probably associated with PF4. PF4 precipitated from human platelet extract at pH 4.0, but this is probably due to the difference in the two biochemical environments investigated, i.e. serum and platelet extract.The gel filtration experiments revealed striking similarities between the major antiheparin activities of serum and platelet extract. At physiological pH and ionic strength both activities were associated with high molecular weight material, but at physiological pH and elevated ionic strength both activities behaved as much smaller entities of molecular weight between 25,000 and 30,000 daltons and it seems very likely that both activities are associated with the same molecule, i.e. PF4.

Allogeneic Platelet-Rich Plasma Therapy as an Effective and Safe Adjuvant Method for Chronic Wounds

2020 ◽  
Vol 246 ◽  
pp. 284-291 ◽  
Author(s):  
Xuan Liao ◽  
Jun-Xian Liang ◽  
Sheng-Hong Li ◽  
Su Huang ◽  
Jian-Xin Yan ◽  
...  
Keyword(s):  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Plasma Therapy

Burn scar assessment: A systematic review of objective scar assessment tools

Burns ◽  
2010 ◽  
Vol 36 (8) ◽  
pp. 1157-1164 ◽  
Author(s):  
Nele Brusselaers ◽  
Ali Pirayesh ◽  
Henk Hoeksema ◽  
Jozef Verbelen ◽  
Stijn Blot ◽  
...  
Keyword(s):  
Systematic Review ◽  
Assessment Tools ◽  
Burn Scar ◽  
Scar Assessment

Effect of Platelet-rich Plasma Therapy Associated With Exercise Training in Musculoskeletal Healing in Rats

2014 ◽  
Vol 46 (6) ◽  
pp. 1879-1881 ◽  
Author(s):  
R.C. Cunha ◽  
J.C. Francisco ◽  
M.A. Cardoso ◽  
L.F. Matos ◽  
D. Lino ◽  
...  
Keyword(s):  
Exercise Training ◽  
Platelet Rich Plasma ◽  
Plasma Therapy

scholarly journals The Sweat Glands and Hair Follicles of European Cattle

1972 ◽  
Vol 25 (3) ◽  
pp. 585 ◽  
Author(s):  
D Mcewan Jenkinson ◽  
T Nay
Keyword(s):  
Hair Follicle ◽  
Sweat Gland ◽  
Hair Follicles ◽  
Sweat Glands ◽  
Mean Values ◽  
The Mean ◽  
European Cattle

Measurements were made on the skins of 1363 cattle from different European breeds. The mean values of these measurements have been tabulated for each breed and the skin types present in each breed or group of breeds have been determined using sweat gland shape (LID) and hair follicle depth (FrY) as the principal bases of comparison.

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