Allogeneic Platelet-Rich Plasma Therapy as an Effective and Safe Adjuvant Method for Chronic Wounds

2020 ◽  
Vol 246 ◽  
pp. 284-291 ◽  
Author(s):  
Xuan Liao ◽  
Jun-Xian Liang ◽  
Sheng-Hong Li ◽  
Su Huang ◽  
Jian-Xin Yan ◽  
...  
Keyword(s):  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Plasma Therapy

The “biological chamber” method – use of autologous platelet-rich plasma (PRP) in the treatment of poorly healing lower-leg ulcers of venous origin

2015 ◽  
Vol 87 (6) ◽  
Author(s):  
Dariusz Waniczek ◽  
Wojciech Mikusek ◽  
Tomasz Kamiński ◽  
Mariusz Wesecki ◽  
Zbigniew Lorenc ◽  
...  
Keyword(s):  
Growth Factors ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Lower Leg ◽  
Complete Healing ◽  
Leg Ulcers ◽  
Plasma Therapy ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

AbstractWound healing is a complex pathophysiological process, in which platelets play a crucial role. Platelet alpha-granules release growth factors to the wound bed; the factors are necessary in the healing process. In chronic wounds, such as poorly healing lower-leg ulcers of venous origin, there is decreased activity of multiple growth factors, so the concept of exogenous delivery of such factors seems a logical strategy. Platelet-rich plasma therapy in patients with lower-leg ulcers of venous origin combined with conventional treatment methods (previously ineffective in these patients) seems, based on our observation, an important adjunct leading to recovery.The aim of the study was to present an original method of autologous platelet-rich plasma application through the creation of a sort of “biological chamber” containing a concentrate of growth factors.Material and methods. The described therapy was implemented in 10 patients, who had been ineffectively treated for more than one year in the outpatient setting. Patients with exacerbation of inflammatory process, signs of wound infection and ankle brachial pressure index < 0.8 were excluded from the study. After the application of platelet-rich plasma, further treatment was continued with the use of moist therapy and compression therapy according to a uniform regimen.Results. Complete healing was achieved within 4-10 weeks from the beginning of the product administration in all patients.Conclusion. The presented method seems technically simple, effective and relatively inexpensive

scholarly journals Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

2021 ◽  
Vol 22 (4) ◽  
pp. 1538 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Wound Healing ◽  
Soft Tissue ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Skin Wounds ◽  
Soft Tissue Defects ◽  
Chronic Skin ◽  
Tissue Defects

The number of clinical trials evaluating adipose-derived mesenchymal stem cells (AD-MSCs), platelet-rich plasma (PRP), and biomaterials efficacy in regenerative plastic surgery has exponentially increased during the last ten years. AD-MSCs are easily accessible from various fat depots and show intrinsic plasticity in giving rise to cell types involved in wound healing and angiogenesis. AD-MSCs have been used in the treatment of soft tissue defects and chronic wounds, employed in conjunction with a fat grafting technique or with dermal substitute scaffolds and platelet-rich plasma. In this systematic review, an overview of the current knowledge on this topic has been provided, based on existing studies and the authors’ experience. A multistep search of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database, and Cochrane databases has been performed to identify papers on AD-MSCs, PRP, and biomaterials used in soft tissue defects and chronic wounds. Of the 2136 articles initially identified, 422 articles focusing on regenerative strategies in wound healing were selected and, consequently, only 278 articles apparently related to AD-MSC, PRP, and biomaterials were initially assessed for eligibility. Of these, 85 articles were excluded as pre-clinical, experimental, and in vitro studies. For the above-mentioned reasons, 193 articles were selected; of this amount, 121 letters, expert opinions, commentary, and editorials were removed. The remaining 72 articles, strictly regarding the use of AD-MSCs, PRP, and biomaterials in chronic skin wounds and soft tissue defects, were analyzed. The studies included had to match predetermined criteria according to the patients, intervention, comparator, outcomes, and study design (PICOS) approach. The information analyzed highlights the safety and efficacy of AD-MSCs, PRP, and biomaterials on soft tissue defects and chronic wounds, without major side effects.

Effect of Platelet-rich Plasma Therapy Associated With Exercise Training in Musculoskeletal Healing in Rats

2014 ◽  
Vol 46 (6) ◽  
pp. 1879-1881 ◽  
Author(s):  
R.C. Cunha ◽  
J.C. Francisco ◽  
M.A. Cardoso ◽  
L.F. Matos ◽  
D. Lino ◽  
...  
Keyword(s):  
Exercise Training ◽  
Platelet Rich Plasma ◽  
Plasma Therapy

Allogenic Pure Platelet-Rich Plasma Therapy for Rotator Cuff Disease: A Bench and Bed Study: Letter to the Editor

2019 ◽  
Vol 47 (5) ◽  
pp. NP36-NP37
Author(s):  
Jeremy Magalon ◽  
Melanie Velier ◽  
Marie Vogtensperger ◽  
Julie Veran ◽  
Fanny Grimaud ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Platelet Rich Plasma ◽  
Rotator Cuff Disease ◽  
Plasma Therapy ◽  
Letter To The Editor

18F-FDG PET Uptake in the Scalp After Platelet-Rich Plasma Therapy

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Sharjeel Usmani ◽  
Dalal Al-Turkait ◽  
Fareeda Al-Kandari ◽  
Najeeb Ahmed
Keyword(s):  
Fdg Pet ◽  
Platelet Rich Plasma ◽  
Plasma Therapy ◽  
18F Fdg

Role of autologous platelet rich plasma in management of chronic wounds

Chirurgia ◽  
2021 ◽  
Vol 34 (2) ◽  
Author(s):  
Walid M. GAMAL ◽  
Mohammed A. OMAR ◽  
Aly H. RASHWAN ◽  
Abdrheem F. MOHAMED
Keyword(s):  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization

2020 ◽  
Vol 8 ◽  
Author(s):  
Pengcheng Xu ◽  
Yaguang Wu ◽  
Lina Zhou ◽  
Zengjun Yang ◽  
Xiaorong Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Wound Repair ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Skin Wound ◽  
Local Inflammation ◽  
Skin Wound Healing

Abstract Background Autologous platelet-rich plasma (PRP) has been suggested to be effective for wound healing. However, evidence for its use in patients with acute and chronic wounds remains insufficient. The aims of this study were to comprehensively examine the effectiveness, synergy and possible mechanism of PRP-mediated improvement of acute skin wound repair. Methods Full-thickness wounds were made on the back of C57/BL6 mice. PRP or saline solution as a control was administered to the wound area. Wound healing rate, local inflammation, angiogenesis, re-epithelialization and collagen deposition were measured at days 3, 5, 7 and 14 after skin injury. The biological character of epidermal stem cells (ESCs), which reflect the potential for re-epithelialization, was further evaluated in vitro and in vivo. Results PRP strongly improved skin wound healing, which was associated with regulation of local inflammation, enhancement of angiogenesis and re-epithelialization. PRP treatment significantly reduced the production of inflammatory cytokines interleukin-17A and interleukin-1β. An increase in the local vessel intensity and enhancement of re-epithelialization were also observed in animals with PRP administration and were associated with enhanced secretion of growth factors such as vascular endothelial growth factor and insulin-like growth factor-1. Moreover, PRP treatment ameliorated the survival and activated the migration and proliferation of primary cultured ESCs, and these effects were accompanied by the differentiation of ESCs into adult cells following the changes of CD49f and keratin 10 and keratin 14. Conclusion PRP improved skin wound healing by modulating inflammation and increasing angiogenesis and re-epithelialization. However, the underlying regulatory mechanism needs to be investigated in the future. Our data provide a preliminary theoretical foundation for the clinical administration of PRP in wound healing and skin regeneration.

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