scholarly journals Tonsillectomy, appendectomy and splenectomy: sequels and malignant evolution

2021 ◽  
Vol 6 (12) ◽  
Keyword(s):  
Protective Effect ◽  
Lymphoid Organs ◽  
Lymphoid Tissues ◽  
Experimental Animals ◽  
Immune Alterations ◽  
Total Splenectomy ◽  
Secondary Lymphoid Organs

The excision of secondary lymphoid organs might not be harmless. Although the procedure itself, is less and less performed presently, infectious sequels in total splenectomy might occur and are possibly fatal. Among further complications, thromboembolic and immune alterations should also be expected. The most debatable of consequences, probably associated with an immune adjustment, concerns the development of malignancies. Considering post-splenectomy tumors, discrepancies emerge between their occurrence in humans, and their consequent protective effect in experimental animals. It is recommended that surgeons aspire at preserving as much of lymphoid tissues a feasible, when performing such resections.

scholarly journals Menangle virus, a pteropid bat paramyxovirus infectious for pigs and humans, exhibits tropism for secondary lymphoid organs and intestinal epithelium in weaned pigs

2012 ◽  
Vol 93 (5) ◽  
pp. 1007-1016 ◽  
Author(s):  
Timothy R. Bowden ◽  
John Bingham ◽  
Jennifer A. Harper ◽  
David B. Boyle
Keyword(s):  
Real Time ◽  
Intestinal Epithelium ◽  
Neutralizing Antibodies ◽  
Time Course ◽  
Lymphoid Organs ◽  
Lymphoid Tissues ◽  
Rt Pcr ◽  
Weaned Pigs ◽  
Reproductive Disease ◽  
Secondary Lymphoid Organs

This study is the first report of experimental infection and transmission of Menangle virus (MenPV) in pigs. Isolated in 1997 from piglets that were stillborn at a large commercial piggery in New South Wales, Australia, MenPV is a recently identified paramyxovirus of bat origin that causes severe reproductive disease in pigs and an influenza-like illness, with a rash, in humans. Although successfully eradicated from the infected piggery, the virus was only isolated from affected fetuses and stillborn piglets during the period of reproductive disease, and thus the mode of transmission between pigs was not established. To investigate the pathogenesis of MenPV, we undertook time-course studies in 6-week-old pigs following intranasal administration of a low-passage, non-plaque-purified isolate from the lung of an infected stillborn piglet. Viraemia was of short duration and low titre, as determined by real-time RT-PCR and virus isolation. Following an incubation period of 2–3 days, virus was shed in nasal and oral secretions, faeces and urine, typically for less than 1 week. Cessation of shedding correlated with the development of neutralizing antibodies in sera. Secondary lymphoid organs and intestine were identified, using quantitative real-time RT-PCR, as major sites of viral replication and dissemination, and this was confirmed by positive immunolabelling of viral antigen within various lymphoid tissues and intestinal epithelium. These data provide new insights into the pathogenesis of MenPV in weaned pigs, and will facilitate future control and eradication programmes should it ever re-emerge in the pig population.

scholarly journals Neutrophils in secondary lymphoid organs

Immunology ◽  
2021 ◽  
Author(s):  
Laurence S. C. Lok ◽  
Menna R. Clatworthy
Keyword(s):  
Lymphoid Organs ◽  
Secondary Lymphoid Organs

Trafficking of ifnγ-primed MSCs to secondary lymphoid organs after hematopoietic cell transplantation

Cytotherapy ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. S35
Author(s):  
A.J. Burnham ◽  
E. Foppiani ◽  
S. Romanelli ◽  
J. moore ◽  
R.E. Burnham ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Lymphoid Organs ◽  
Hematopoietic Cell ◽  
Secondary Lymphoid Organs

Quantitation and visualization of tumor-specific T cells in the secondary lymphoid organs during and after tumor elimination by PET

2004 ◽  
Vol 31 (8) ◽  
pp. 1021-1031 ◽  
Author(s):  
Ken Matsui ◽  
Zheng Wang ◽  
Timothy J. McCarthy ◽  
Paul M. Allen ◽  
David E. Reichert
Keyword(s):  
T Cells ◽  
Lymphoid Organs ◽  
Secondary Lymphoid Organs

scholarly journals Development of Secondary Lymphoid Organs

2008 ◽  
Vol 26 (1) ◽  
pp. 627-650 ◽  
Author(s):  
Troy D. Randall ◽  
Damian M. Carragher ◽  
Javier Rangel-Moreno
Keyword(s):  
Lymphoid Organs ◽  
Secondary Lymphoid Organs

Modeling immune reactivity in secondary lymphoid organs

1992 ◽  
Vol 54 (4) ◽  
pp. 649-672 ◽  
Author(s):  
Alan S. Perelson ◽  
Gérand Weisbuch
Keyword(s):  
Lymphoid Organs ◽  
Immune Reactivity ◽  
Secondary Lymphoid Organs

scholarly journals Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin

2005 ◽  
Vol 201 (4) ◽  
pp. 509-515 ◽  
Author(s):  
William Vermi ◽  
Elena Riboldi ◽  
Valerie Wittamer ◽  
Francesca Gentili ◽  
Walter Luini ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lupus Erythematosus ◽  
Normal Skin ◽  
Cell Monolayer ◽  
Lymphoid Organs ◽  
High Endothelial Venules ◽  
Luminal Side ◽  
Plasmacytoid Dcs ◽  
Secondary Lymphoid Organs

Chemerin is a chemotactic agent that was recently identified as the ligand of ChemR23, a serpentine receptor expressed by activated macrophages and monocyte-derived dendritic cells (DCs). This paper shows that blood plasmacytoid and myeloid DCs express functional ChemR23. Recombinant chemerin induced the transmigration of plasmacytoid and myeloid DCs across an endothelial cell monolayer. In secondary lymphoid organs (lymph nodes and tonsils), ChemR23 is expressed by CD123+ plasmacytoid DCs and by CD1a+ DC-SIGN+ DCs in the interfollicular T cell area. ChemR23+ DCs were also observed in dermis from normal skin, whereas Langerhans cells were negative. Chemerin expression was selectively detected on the luminal side of high endothelial venules in secondary lymphoid organs and in dermal endothelial vessels of lupus erythematosus skin lesions. Chemerin+ endothelial cells were surrounded by ChemR23+ plasmacytoid DCs. Thus, ChemR23 is expressed and functional in plasmacytoid DCs, a property shared only by CXCR4 among chemotactic receptors. This finding, together with the selective expression of the cognate ligand on the luminal side of high endothelial venules and inflamed endothelium, suggests a key role of the ChemR23/chemerin axis in directing plasmacytoid DC trafficking.

scholarly journals IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without De Novo Infiltration from Secondary Lymphoid Organs

2012 ◽  
Vol 72 (14) ◽  
pp. 3570-3581 ◽  
Author(s):  
Jan Emmerich ◽  
John B. Mumm ◽  
Ivan H. Chan ◽  
Drake LaFace ◽  
Hoa Truong ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
De Novo ◽  
Lymphoid Organs ◽  
Secondary Lymphoid Organs
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