51. Lessons Learned in Exposure Modeling for Quantitative Health Risk Assessment and Risk Management: One Individual'S Experiences

Author(s):  
S.F. Arnold
Author(s):  
Graham A. Colditz ◽  
Hank Dart

Abstract The Your Disease Risk tool (yourdiseaserisk.wustl.edu) went live to the public in January 2000 and was one of the first personalized health risk assessment sites on the Internet. Its launch marked the culmination of years of work by a large, multi-disciplinary university team whose primary goal was to translate the science on cancer prevention into accurate, engaging, and useful messages for the public. Today, 20 years on, Your Disease Risk has expanded from its initial four cancers to include 18 different tools designed for today’s users. This commentary reviews important moments and lessons learned in the first two decades of Your Disease Risk.


2021 ◽  
Author(s):  
Douglas Theodore Cousins

Combined air emissions from multiple petrochemical facilities operating in the area known as Chemical Valley in Sarnia, Ontario, Canada, have led to escalating concerns over health effects to nearby residents. By conducting a quantitative health risk assessment of ambient air data collected from 2008-2014, this thesis investigated whether current emissions are resulting in increased health risk for the population living near Chemical Valley. The results of this analysis are that health risks are slightly higher than levels considered acceptable for large populations, but are within levels often accepted for smaller groups based on the traditional risk assessment - risk management paradigm. Interpreting these results in the context of the literature about the science-policy interface, and environmental dispute resolution, this thesis highlights several problems with using the traditional risk assessment - risk management paradigm as the basis for decision-making in environmental disputes— particularly when the affected population is Indigenous.


2008 ◽  
Vol 13 (1_suppl) ◽  
pp. 35-40 ◽  
Author(s):  
Andrea Seymour ◽  
Kathryne Dupré

Background In recent years, there has been increased focus on improving the quality of the working lives of staff in health care organizations. Research shows that improvements can be achieved through a comprehensive organizational approach to workplace health. Improved worker engagement is a realizable outcome of such an approach, provided that it is based on reliable and relevant data and is tailored to the specific environment in which it is being implemented. Assessment of problem An intervention project was designed to develop an organization-wide approach to employee workplace health. A comprehensive health risk assessment was undertaken, along with a staff survey on workplace culture, individual health practice and environmental effects on physical health. Results In general, the findings present a positive picture of the culture and factors that influence psychological wellbeing. However, improvement is needed in some areas: satisfaction is only marginally outweighing stress, and musculoskeletal disorders account for much absenteeism. Employee health needs include weight management, improving fitness and nutrition, and decreasing coronary risk. Strategies for change Results have prompted this organization to pursue the development of a Healthy Workplace Policy that will be used as a filter for all other policies relating to workplace culture, environment and practice, and have provided the impetus and focus to review the organization of employee health services. Lessons learned Three major administrative activities are necessary to move from planning to sustained action: ensure adherence of all staff to any policy derived from a health risk assessment; ensure staff feel proposed changes are relevant and important; and create a road map to guide the development of a strategic and an implementation plan. The findings outlined in this report can be addressed by organizations that are willing to commit to a comprehensive approach to workplace health.


2006 ◽  
Vol 25 (1) ◽  
pp. 29-43 ◽  
Author(s):  
P F Ricci ◽  
L A Cox ◽  
T R MacDonald

How can empirical evidence of adverse effects from exposure to noxious agents, which is often incomplete and uncertain, be used most appropriately to protect human health? We examine several important questions on the best uses of empirical evidence in regulatory risk management decision–making raised by the US Environmental Protection Agency (EPA)'s science–policy concerning uncertainty and variability in human health risk assessment. In our view, the US EPA (and other agencies that have adopted similar views of risk management) can often improve decision–making by decreasing reliance on default values and assumptions, particularly when causation is uncertain. This can be achieved by more fully exploiting decision–theoretic methods and criteria that explicitly account for uncertain, possibly conflicting scientific beliefs and that can be fully studied by advocates and adversaries of a policy choice, in administrative decision–making involving risk assessment. The substitution of decision–theoretic frameworks for default assumption–driven policies also allows stakeholder attitudes toward risk to be incorporated into policy debates, so that the public and risk managers can more explicitly identify the roles of risk–aversion or other attitudes toward risk and uncertainty in policy recommendations. Decision theory provides a sound scientific way explicitly to account for new knowledge and its effects on eventual policy choices. Although these improvements can complicate regulatory analyses, simplifying default assumptions can create substantial costs to society and can prematurely cut off consideration of new scientific insights (e.g., possible beneficial health effects from exposure to sufficiently low ‘hormetic’ doses of some agents). In many cases, the administrative burden of applying decision–analytic methods is likely to be more than offset by improved effectiveness of regulations in achieving desired goals. Because many foreign jurisdictions adopt US EPA reasoning and methods of risk analysis, it may be especially valuable to incorporate decision–theoretic principles that transcend local differences among jurisdictions.


Author(s):  
Ajeng Kurniasari Putri

Opah fish(Lampris guttatus) is one of the bycatch products of Tuna fish captured originally from Indonesia that currently has become as one of the exported commodities. However, it is stated that these fish contains high formaldehyde up to 200 ppm, which is strongly suspected naturally due to deterioration. Furthermore, the aim of this study is to obtain the data of probabilistic health risk assessment due to consumption of opah fish that contaminated with natural formaldehyde. The study was conducted on opah fish (Lampris guttatus) that were analyzed the formaldehyde concentration in it. Along with the consumption data, body weight and the formaldehyde concentration included two others simulations of two times and four times of formaldehyde value, probabilistic dietary exposure was calculated by @Risk and produced some data regard to health risk. The result showed that Opah fish caught in Indonesian waters could produce formaldehyde naturally due to deterioration process ranged from 4,62 ± 0,00 mg/kg to 58,10 ± 0,46 mg/kg. Consequently, the residents of female children in Jakarta and Surabaya considered as in health risk problems. Extremely, the further simulations of two times and four times of formaldehyde concentration showed the health risk to all residents in Jakarta and Surabaya included male, female, children, and adult. Therefore, the stakeholders included government and policymakers should take some priorities to formulating a proper risk management strategy on the basis of knowledge of endogenous formaldehyde present in Opah fish and risk management strategies for the fish consumer in Indonesia.


2021 ◽  
Author(s):  
Douglas Theodore Cousins

Combined air emissions from multiple petrochemical facilities operating in the area known as Chemical Valley in Sarnia, Ontario, Canada, have led to escalating concerns over health effects to nearby residents. By conducting a quantitative health risk assessment of ambient air data collected from 2008-2014, this thesis investigated whether current emissions are resulting in increased health risk for the population living near Chemical Valley. The results of this analysis are that health risks are slightly higher than levels considered acceptable for large populations, but are within levels often accepted for smaller groups based on the traditional risk assessment - risk management paradigm. Interpreting these results in the context of the literature about the science-policy interface, and environmental dispute resolution, this thesis highlights several problems with using the traditional risk assessment - risk management paradigm as the basis for decision-making in environmental disputes— particularly when the affected population is Indigenous.


1993 ◽  
Author(s):  
L.D. Hamilton ◽  
S. Holtzman ◽  
A.F. Meinhold ◽  
S.C. Morris ◽  
M.D. Rowe ◽  
...  

2015 ◽  
Vol 45 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Nikolai L. Chepelev ◽  
Ivy D. Moffat ◽  
Sarah Labib ◽  
Julie Bourdon-Lacombe ◽  
Byron Kuo ◽  
...  

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