Efforts and Challenges paved by India to confront of Corona Virus (COVID-19)

The clinical range of Covid-19 is a respiratory route infection that varies from Asymptomatic to various clinical conditions such as respiratory failure to multiple organ dysfunction syndromes (MODS). Government administration officials are ramping up many efforts i.e prevention and containing the spread from escalating to the next level, raising the quarantine stations and increase in the laboratory capacity, strengthening surveillance, contact tracing using artificial intelligence (AI) via technology apps. India is Consequently facing many challenges to tackle the pandemic from shortage of medical supply to the devastation of the educational, transportation, job sectors, and healthcare sector, However, pharmaceutical companies taking center stage in the Covid-19 fight, Other pharmaceutical companies(low scale) in India are following suit during the Covid-19 pandemic and using their capabilities to lighten the burden of coronavirus, WHO recommends social distancing and country-wise lockdown are very essential to tackle the coronavirus, the GOI is scheming on how to get back to normalcy, with an actionable exit plan for the states to confront the coronavirus Bangladesh Journal of Medical Science Vol.19(0) 2020 p. S 88-S 92

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Disseminated intravascular coagulation in meningococcal sepsis

Hämostaseologie ◽

10.1055/s-0037-1619581 ◽

2003 ◽

Vol 23 (03) ◽

pp. 125-130 ◽

Cited By ~ 2

Author(s):

S. Zeerleder ◽

R. Zürcher Zenklusen ◽

C. E. Hack ◽

W. A. Wuillemin

Keyword(s):

Organ Dysfunction ◽

Disseminated Intravascular Coagulation ◽

Skin Necrosis ◽

Multiple Organ ◽

Meningococcal Sepsis ◽

Multiple Organ Dysfunction ◽

Intravascular Coagulation ◽

Therapeutic Concepts ◽

New Therapeutic Concepts ◽

Coagulation And Fibrinolysis

SummaryWe report on a man (age: 49 years), who died from severe meningococcal sepsis with disseminated intravascular coagulation (DIC), multiple organ dysfunction syndrome and extended skin necrosis. We discuss in detail the pathophysiology of the activation of coagulation and fibrinolysis during sepsis. The article discusses new therapeutic concepts in the treatment of disseminated intravascular coagulation in meningococcal sepsis, too.

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Multiple Organ Dysfunction Syndrome of Alcoholic Origin in an 18-Year-Old Patient

The International Annals of Medicine ◽

10.24087/iam.2018.2.12.712 ◽

2018 ◽

Vol 2 (12) ◽

Author(s):

Francesco Gazia ◽

Giacomo De Luca ◽

Imbalzano Gabriele ◽

Vincenzo Pellicanò

Keyword(s):

Organ Dysfunction ◽

Multiple Organ Dysfunction Syndrome ◽

Multiple Organ ◽

Multiple Organ Dysfunction

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IMPACT probability of poor outcome and plasma cytokine concentrations are associated with multiple organ dysfunction syndrome following traumatic brain injury

Journal of Neurosurgery ◽

10.3171/2018.8.jns18676 ◽

2019 ◽

Vol 131 (6) ◽

pp. 1931-1937 ◽

Cited By ~ 2

Author(s):

Sungho Lee ◽

Hyunsoo Hwang ◽

Jose-Miguel Yamal ◽

J. Clay Goodman ◽

Imoigele P. Aisiku ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Organ Dysfunction ◽

Multiple Organ Dysfunction Syndrome ◽

Sofa Score ◽

Plasma Concentrations ◽

Multiple Organ ◽

Multiple Organ Dysfunction ◽

Poor Outcome ◽

Initial Plasma

OBJECTIVETraumatic brain injury (TBI) is a major cause of morbidity and mortality. Multiple organ dysfunction syndrome (MODS) occurs frequently after TBI and independently worsens outcome. The present study aimed to identify potential admission characteristics associated with post-TBI MODS.METHODSThe authors performed a secondary analysis of a recent randomized clinical trial studying the effects of erythropoietin and blood transfusion threshold on neurological recovery after TBI. Admission clinical, demographic, laboratory, and imaging parameters were used in a multivariable Cox regression analysis to identify independent risk factors for MODS following TBI, defined as maximum total Sequential Organ Failure Assessment (SOFA) score > 7 within 10 days of TBI.RESULTSTwo hundred patients were initially recruited and 166 were included in the final analysis. Respiratory dysfunction was the most common nonneurological organ system dysfunction, occurring in 62% of the patients. International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) probability of poor outcome at admission was significantly associated with MODS following TBI (odds ratio [OR] 8.88, 95% confidence interval [CI] 1.94–42.68, p < 0.05). However, more commonly used measures of TBI severity, such as the Glasgow Coma Scale, Injury Severity Scale, and Marshall classification, were not associated with post-TBI MODS. In addition, initial plasma concentrations of interleukin (IL)–6, IL-8, and IL-10 were significantly associated with the development of MODS (OR 1.47, 95% CI 1.20–1.80, p < 0.001 for IL-6; OR 1.26, 95% CI 1.01–1.58, p = 0.042 for IL-8; OR 1.77, 95% CI 1.24–2.53, p = 0.002 for IL-10) as well as individual organ dysfunction (SOFA component score ≥ 1). Finally, MODS following TBI was significantly associated with mortality (OR 5.95, 95% CI 2.18–19.14, p = 0.001), and SOFA score was significantly associated with poor outcome at 6 months (Glasgow Outcome Scale score < 4) when analyzed as a continuous variable (OR 1.21, 95% CI 1.06–1.40, p = 0.006).CONCLUSIONSAdmission IMPACT probability of poor outcome and initial plasma concentrations of IL-6, IL-8, and IL-10 were associated with MODS following TBI.

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A novel ITPA variant causes epileptic encephalopathy with multiple-organ dysfunction

Journal of Human Genetics ◽

10.1038/s10038-020-0765-3 ◽

2020 ◽

Vol 65 (9) ◽

pp. 751-757 ◽

Cited By ~ 1

Author(s):

Masamune Sakamoto ◽

Den Kouhei ◽

Muzhirah Haniffa ◽

Sebastián Silva ◽

Mónica Troncoso ◽

...

Keyword(s):

Organ Dysfunction ◽

Epileptic Encephalopathy ◽

Multiple Organ ◽

Multiple Organ Dysfunction

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The successful treatment of multiple organ dysfunction syndrome and severe hypernatremia, secondary to joint supplement toxicity in a dog

Journal of Veterinary Emergency and Critical Care ◽

10.1111/vec.13033 ◽

2021 ◽

Author(s):

Harry O. Weatherson ◽

Tara Bellis ◽

Yuki Tse

Keyword(s):

Organ Dysfunction ◽

Multiple Organ Dysfunction Syndrome ◽

Successful Treatment ◽

Multiple Organ ◽

Multiple Organ Dysfunction

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Coronavirus Disease 2019 in a Hemodialysis Patient

Blood Purification ◽

10.1159/000507877 ◽

2020 ◽

Vol 49 (6) ◽

pp. 761-764 ◽

Cited By ~ 1

Author(s):

Hai Yuan ◽

E. Guo ◽

Zhao Gao ◽

Fengqi Hu ◽

Li Lu

Keyword(s):

Mechanical Ventilation ◽

Polymerase Chain Reaction ◽

Hemodialysis Patient ◽

Multiple Organ ◽

Lung Imaging ◽

Maintenance Hemodialysis ◽

Multiple Organ Dysfunction ◽

Chain Reaction ◽

Pharyngeal Swab ◽

Polymerase Chain

There has been a global outbreak of the coronavirus disease 2019 (COVID-19) since December 2019. Here, we describe the case of a 49-year-old male undergoing maintenance hemodialysis (HD) who got infected with COVID-19 and our experience in performing HD for him. The patient’s symptoms and lung imaging changes were atypical. However, his lymphocyte range decreased upon admission and the polymerase chain reaction of the pharyngeal swab for the COVID-19 nucleic acid was positive. The patient developed respiratory failure and required mechanical ventilation 8 days after admission. In the end, he died from multiple organ dysfunction syndrome. The difficulties in diagnosis, infection control, and treatment of COVID-19 in maintenance HD patients are discussed in this report.

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