A Case of Idiopathic Chronic Inflammatory Demyelinating Polyradiculoneuropathy

A 40 years old man presented with progressive weakness and distal paraesthesia of limbs with difficulty in walking for last seven years. As the patient was not investigated thoroughly, a diagnostic dilemma was persisted. This patient went abroad & investigated thoroughly and yet not reached to a confirm diagnosis. Subsequently this patient reported to us and diagnosed it to be a case of Idiopathic Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) responded to oral steroid therapy. After follow-up, this patient showed marked improvement. So diagnostic dilemma that persisted with such a patient that showed improvement with treatment and a challenge to a treatable condition had encouraged us to report the case. DOI: http://dx.doi.org/10.3329/bjn.v28i2.17185 Bangladesh Journal of Neuroscience 2012; Vol. 28 (2): 132-140

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Focal vasculitic myositis as a primary manifestation of Behçet’s disease: a case series of 10 Korean patients in a locomotive medicine clinic

Rheumatology ◽

10.1093/rheumatology/keab053 ◽

2021 ◽

Author(s):

Du Hwan Kim ◽

Sun Woong Kim ◽

Seung Mi Yeo ◽

Min-Soo Kang ◽

Young Cheol Yoon ◽

...

Keyword(s):

Steroid Therapy ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Adult Patients ◽

Oral Steroid ◽

Imaging Findings ◽

Behcet's Disease ◽

Medicine Clinic ◽

Oral Steroid Therapy

Abstract Objectives Muscle involvement in Behçet’s disease (BD) is rare, and several cases have been reported in the literature. Therefore, this study aimed to describe the clinical, laboratory and imaging findings in adult patients presenting with BD-associated myositis before the diagnosis of BD. Methods We retrospectively screened patients who visited a locomotive medicine clinic presenting with myalgia, local swelling, or tenderness of extremities without an established diagnosis of BD. We enrolled patients whose pain in the extremities was proven to be suggestive of focal vasculitic myositis and who were eventually diagnosed as having BD at the initial visit or during follow-up. We thoroughly reviewed the clinical, histological and imaging findings and treatment outcomes in patients who presented with focal vasculitic myositis as the primary manifestation of BD. Results Ten adult patients with focal vasculitic myositis as the primary manifestation of BD were enrolled. The lower and upper extremities were affected in eight and two patients, respectively. The affected lower extremities were the calf (n = 6) and thigh muscles (n = 2). The common findings of MRI included high signal intensity of the affected muscles and intermuscular fascia on fat-suppressed images, suggestive of myofascitis and oedematous changes in the subcutaneous layer. The results of skin or muscle biopsy were suggestive of vasculitis. All the patients were pain-free at the short-term follow-up (1–3 weeks) after oral steroid therapy. Conclusion Focal vasculitic myositis can be a primary manifestation of BD warranting medical attention. BD-associated myositis responds well to oral steroid therapy.

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Comparison of the Therapeutic Efficacy of Methylprednisolone Pulse Therapy and Oral Steroid Therapy in Children with IgA Nephropathy and HSP Nephritis Combined with Proteinuria

Journal of the Korean Society of Pediatric Nephrology ◽

10.3339/jkspn.2014.18.1.24 ◽

2014 ◽

Vol 18 (1) ◽

pp. 24

Author(s):

Ji Young Ahn ◽

Jung Eun Moon ◽

Young Ju Hwang ◽

Bong Seok Choi ◽

Cheol Woo Ko ◽

...

Keyword(s):

Iga Nephropathy ◽

Steroid Therapy ◽

Therapeutic Efficacy ◽

Pulse Therapy ◽

Methylprednisolone Pulse Therapy ◽

Oral Steroid ◽

Methylprednisolone Pulse ◽

Oral Steroid Therapy

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Acute myopathy secondary to oral steroid therapy in a 49-year-old man: a case report

Journal of Medical Case Reports ◽

10.1186/1752-1947-5-82 ◽

2011 ◽

Vol 5 (1) ◽

Cited By ~ 5

Author(s):

Muhammad A Khan ◽

Eric Larson

Keyword(s):

Case Report ◽

Steroid Therapy ◽

Oral Steroid ◽

Oral Steroid Therapy

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Metronidazole ototoxicity - report of two cases

The Journal of Laryngology & Otology ◽

10.1017/s0022215100143968 ◽

1999 ◽

Vol 113 (4) ◽

pp. 355-357 ◽

Cited By ~ 11

Author(s):

S. M. Iqbal ◽

J. G. Murthy ◽

P. K. Banerjee ◽

K. A. Vishwanathan

Keyword(s):

Hearing Loss ◽

Case Report ◽

Oral Administration ◽

Sensorineural Hearing Loss ◽

Steroid Therapy ◽

World Literature ◽

Sensorineural Hearing ◽

Oral Steroid ◽

The World ◽

Oral Steroid Therapy

AbstractTwo cases of bilateral moderate to severe sensorineural hearing loss due to oral administration of metronidazole are reported. There has been only one case report of deafness following metronidazole therapy in the world literature. The hearing loss recovered gradually in a period of four to six weeks following withdrawal of drug and oral steroid therapy. The possible mechanism of ototoxicity is discussed. Awareness by the treating physician of ototoxicity due to any drug is stressed.

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy 101—Pitfalls and Pearls of Diagnosis and Treatment

US Neurology ◽

10.17925/usn.2017.13.01.18 ◽

2017 ◽

Vol 13 (01) ◽

pp. 18 ◽

Cited By ~ 2

Author(s):

Said R Beydoun ◽

Thomas H Brannagan III ◽

Peter Donofrio ◽

Carol Lee Koski ◽

Eric Lancaster ◽

...

Keyword(s):

Peripheral Nerves ◽

Ivig Therapy ◽

Chronic Inflammatory Demyelinating Polyradiculoneuropathy ◽

Sensory Function ◽

Therapeutic Interventions ◽

First Line ◽

Chronic Disability ◽

Treatable Condition ◽

Progressive Weakness

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), which is caused by demyelination of the peripheral nerves, is characterized by progressive weakness and impaired sensory function in the arms and legs. CIDP is a treatable condition in which early diagnosis is crucial to limit chronic disability. CIDP can mimic other neuropathies and it is important to identify these in order to ensure prompt treatment. Patients with other causes of neuropathy should be suspected of having CIDP if there is rapid progress or proximal weakness. Intravenous immunoglobulin (IVIG), corticosteroids, and plasma exchange are first-line therapies. The IVIG CIDP Efficacy (ICE) trial, the largest trial reported of any CIDP treatment, demonstrated that IVIG therapy reduced disability and functional impairment, as well as improved quality of life. Autoantibodies against membrane proteins of the peripheral nerve axons or the myelin sheath have been reported recently, and an improved understanding of antibody responses in CIDP may enable the development of future targeted therapeutic interventions.

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Medication-Refractory Parkinsonian Tremor Requiring Dual Lead Implantation for Tremor Control

Deep Brain Stimulation ◽

10.1093/med/9780190647209.003.0014 ◽

2020 ◽

pp. 73-78

Author(s):

Anhar Hassan

Keyword(s):

Marked Improvement ◽

Motor Fluctuation ◽

Motor Fluctuations ◽

Parkinsonian Tremor ◽

Lead Placement ◽

Patient Reported ◽

Tremor Suppression ◽

Optimal Target ◽

Dual Lead

A 52-year-old man with Parkinson disease (PD) of 9 years’ duration was referred to the DBS clinic for medication-refractory severe unilateral rest and re-emergent tremor and frequent motor fluctuations. He was approved for DBS, with debate over the optimal target to treat severe tremor and fluctuations (subthalamic nucleus [STN] plus/minus the ventral intermediate [Vim] thalamus) and unilateral versus bilateral implantation. The committee decided to perform unilateral STN lead placement first, to provide benefit for both motor fluctuation and tremor, with the option of adding Vim concurrently if required. Intraoperatively, there was incomplete tremor capture, so a second lead was placed in Vim with success. Subsequent DBS programming achieved marked improvement of tremor and fluctuations at low stimulation, although side effects necessitated bipolar configurations in both leads. The patient reported excellent sustained tremor suppression at 2-year follow-up, although motor fluctuations recurred. This case illustrates that for intraoperative stimulation-refractory PD tremor, consideration can be given to adding a second Vim DBS target (dual DBS targets).

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