Metronidazole ototoxicity - report of two cases

1999 ◽  
Vol 113 (4) ◽  
pp. 355-357 ◽  
Author(s):  
S. M. Iqbal ◽  
J. G. Murthy ◽  
P. K. Banerjee ◽  
K. A. Vishwanathan
Keyword(s):  
Hearing Loss ◽  
Case Report ◽  
Oral Administration ◽  
Sensorineural Hearing Loss ◽  
Steroid Therapy ◽  
World Literature ◽  
Sensorineural Hearing ◽  
Oral Steroid ◽  
The World ◽  
Oral Steroid Therapy

AbstractTwo cases of bilateral moderate to severe sensorineural hearing loss due to oral administration of metronidazole are reported. There has been only one case report of deafness following metronidazole therapy in the world literature. The hearing loss recovered gradually in a period of four to six weeks following withdrawal of drug and oral steroid therapy. The possible mechanism of ototoxicity is discussed. Awareness by the treating physician of ototoxicity due to any drug is stressed.

Bilateral profound sudden sensorineural hearing loss presenting a diagnostic conundrum in a child with sickle cell anaemia

2008 ◽  
Vol 123 (7) ◽  
pp. 811-816 ◽  
Author(s):  
A D Mace ◽  
M S Ferguson ◽  
M Offer ◽  
K Ghufoor ◽  
M J Wareing
Keyword(s):  
Hearing Loss ◽  
Case Report ◽  
Sensorineural Hearing Loss ◽  
Sickle Cell ◽  
Cochlear Implantation ◽  
World Literature ◽  
Sickle Cell Anaemia ◽  
Early Recognition ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing

AbstractObjective:To present the first published case of a child with bilateral profound sudden sensorineural hearing loss found in association with sickle cell anaemia, and to demonstrate the importance of early recognition, investigation and empirical treatment of sudden sensorineural hearing loss.Method:Case report and review of world literature.Case report:The authors present the case of a seven-year-old child with known sickle cell anaemia, who presented with bilateral profound sensorineural hearing loss developing over a period of five days. There was a history of ophthalmological disease in the preceding weeks, and inflammatory markers were raised. The differential diagnosis included a vaso-occlusive or inflammatory aetiology such as Cogan's syndrome, and treatment for both was instigated. Hearing thresholds did not recover, and the patient underwent cochlear implantation 12 weeks later.Conclusion:Sudden sensorineural hearing loss has a variable aetiology and is rare in children. Immediate treatment for all possible aetiologies is essential, along with targeted investigations and early referral for cochlear implantation if no recovery is demonstrated.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) presenting with sudden sensorineural hearing loss

2005 ◽  
Vol 119 (2) ◽  
pp. 148-151 ◽  
Author(s):  
John S Phillips ◽  
Jacquelyn A King ◽  
Siddharthan Chandran ◽  
Peter R Prinsley ◽  
David Dick
Keyword(s):  
Hearing Loss ◽  
Family History ◽  
Sensorineural Hearing Loss ◽  
World Literature ◽  
Autosomal Dominant ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Cerebrovascular Events ◽  
The World

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an autosomal dominant angiopathy characterized by recurrent cerebrovascular events, migraine and dementia. We describe a case of sensorineural hearing loss as the presenting feature of this condition. We have found no previous reports in the world literature of CADASIL presenting with a sudden sensorineural hearing loss. The significance of questioning a patient with regard to family history is exemplified in this case.

Unilateral hearing loss as primary symptom of craniopharyngioma in a six-year-old girl

2008 ◽  
Vol 122 (3) ◽  
Author(s):  
R Hofman ◽  
H J Rosingh
Keyword(s):  
Hearing Loss ◽  
Case Report ◽  
Sensorineural Hearing Loss ◽  
Otoacoustic Emissions ◽  
World Literature ◽  
Rare Case ◽  
Sensorineural Hearing ◽  
Unilateral Hearing Loss ◽  
Magnetic Resonance Scanning ◽  
Internal Acoustic Canal

AbstractObjective:We report a rare case of otological presentation of craniopharyngioma.Method:Case report and review of world literature concerning presentations of craniopharyngioma.Results:A six-year-old girl was referred to our department with unilateral hearing loss. This appeared to be a complete sensorineural hearing loss. Otoacoustic emissions were reproducible on both sides. Magnetic resonance scanning revealed a massive, cystic craniopharyngioma exerting pressure on the patient's ventricular system and brainstem and also invading the internal acoustic canal. The mass was resected via a craniotomy. The patient's hearing loss completely recovered, and she experienced no neurological or endocrinological side effects of the treatment. Craniopharyngioma have a prevalence of 0.13–2:100 000.Conclusion:Craniopharyngioma is a rare disease. First presentation with otological symptoms is extremely rare. Otoacoustic emissions can differentiate between cochlear and retrocochlear causes of sensorineural hearing loss.

Intratympanic Steroid Perfusion for Refractory Sudden Sensorineural Hearing Loss

2005 ◽  
Vol 132 (4) ◽  
pp. 527-531 ◽  
Author(s):  
Brian D. Herr ◽  
Sam J. Marzo
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Steroid Therapy ◽  
Round Window ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Catheter Placement ◽  
Oral Steroid ◽  
Systemic Steroid ◽  
Steroid Administration

OBJECTIVE: Patients with sudden sensorineural hearing loss (SSHL) can benefit from systemic steroid therapy. Unfortunately, some patients are not candidates for steroid therapy due to concern over possible complications. Furthermore, not all patients will benefit from steroid administration. This study evaluates the potential benefits and safety of treating patients with SSHL refractory to oral steroids with intratympanic steroid therapy. METHODS: A retrospective case review was performed on all patients who presented with sudden sensorineural hearing loss refractory to oral steroid therapy during the past year. Seventeen patients were identified. All patients underwent intratympanic steroid administration, via MicroWick placement and/or round window catheter placement. RESULTS: Nine patients with sudden sensorineural hearing loss showed an improvement with intratympanic steroid therapy, consisting of MicroWick placement with dexamethasone drop (Decadron) administration for 1–2 weeks and/or round window catheter placement with steroid perfusion. Only one of the patients presenting with hearing loss present for greater than 8 weeks benefited from intratympanic therapy. Complications were few and included tympanic membrane perforation, chronic otitis media, dysequilibrium, and dysguesia. CONCLUSIONS: Intratympanic steroid therapy can be beneficial in treating patients with sudden sensorineural hearing loss refractory to oral steroid use. EBM rating: C.

scholarly journals Effect of Intratympanic Dexamethasone in Idiopathic Sudden Sensorineural Hearing Loss

2019 ◽  
Vol 27 (2) ◽  
pp. 135-139
Author(s):  
Rabi Hembrom ◽  
Indranil Sen ◽  
Bina Tamang ◽  
Satadal Mandal ◽  
Amit Chakrabarti
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Oral Steroid ◽  
Hearing Improvement ◽  
Oral Steroids ◽  
Oral Steroid Therapy ◽  
A Prospective Study ◽  
Intratympanic Dexamethasone

Introduction Oral steroids currently represent the standard treatment for idiopathic sudden sensorineural hearing loss The aim of this study is to assess the effectiveness of intratympanic dexamethasone injection for treating ‘Idiopathic sudden sensori-neural hearing loss’ (ISSNHL) not improved with conventional oral steroid. Materials and Methods A prospective study was conducted on 30 patients refractory to oral steroid therapy between June 2017 to May 2018. ‘Intratympanic dexamethasone injection’ (ITDI) was given every week for 3 consecutive weeks. Hearing was assessed by performing pure tone audiogram before every ITDI and also 1 week after the completion of treatment. Results Hearing improvement was found in 19 out of the 30 cases (63.3%).   Conclusions Intratympanic dexamethasone significantly improves the prognosis of ISSNHL and is a safe, inexpensive and effective treatment.

A case of sensorineural deafness following ingestion of sildenafil

2006 ◽  
Vol 121 (4) ◽  
pp. 395-397 ◽  
Author(s):  
B Mukherjee ◽  
T Shivakumar
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
World Literature ◽  
Oral Treatment ◽  
Sensorineural Deafness ◽  
Sensorineural Hearing ◽  
The Internet ◽  
First Case ◽  
The World ◽  
Harmful Effects

We report a case of bilateral profound unremitting sensorineural hearing loss, in a 44-year-old male patient occurring after ingestion of sildenafil citrate 50 mg/day for 15 days. Audiological evaluation documented the findings. Sildenafil is an effective oral treatment for erectile dysfunction syndrome. It is being used and abused by many people as availability is easy and it can even be bought over the internet. Many patients are unaware of the harmful effects of sildenafil and take the drug without medical supervision. We could not find any previously reported cases of sildenafil induced hearing loss and to the best of our knowledge, this is the first case report of sildenafil induced sensorineural hearing loss in the world literature.

Efficacy of low-dose intratympanic dexamethasone as a salvage treatment for idiopathic sudden sensorineural hearing loss: the Modbury Hospital experience

2014 ◽  
Vol 128 (S2) ◽  
pp. S27-S30 ◽  
Author(s):  
S Oue ◽  
J Jervis-Bardy ◽  
L Stepan ◽  
S Chong ◽  
C-K L Shaw
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Pure Tone ◽  
Low Dose ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Oral Steroid ◽  
Dexamethasone Therapy ◽  
Oral Steroid Therapy ◽  
Intratympanic Dexamethasone

AbstractObjective:To evaluate the efficacy of low-dose intratympanic dexamethasone therapy in patients with idiopathic sudden sensorineural hearing loss whose hearing in the affected ear had failed to improve following a course of oral steroid therapy.Methods:A prospective pilot study was undertaken of eight patients with idiopathic sudden sensorineural hearing loss whose hearing had failed to improve after a course of prednisolone. These patients subsequently received 8 mg intratympanic dexamethasone therapy, delivered via a ventilation tube on a weekly basis for 1 month. Clinical outcome was assessed weekly with pure tone audiography.Results:At the end of the 1-month treatment period, no significant hearing improvement was observed on pure tone audiography in any of the patients (i.e. improvements were all less than 10 dB).Conclusion:The response to 8 mg of intratympanic dexamethasone used as a salvage therapy for idiopathic sudden sensorineural hearing loss was inadequate. A higher dosage of intratympanic dexamethasone might be required to achieve better outcomes.

Sensorineural hearing loss as a problem of modern otolaryngology (review)

2020 ◽  
pp. 50-64
Author(s):  
Anton Zhuravlev
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Social Activity ◽  
Healthy Person ◽  
Sensorineural Hearing ◽  
Significant Part ◽  
The World ◽  
Preservation And Restoration

The article presents an overview of factors that contribute to the development of sensorineural hearing loss, and approaches to solving this problem. Considering that we receive a significant part of information about the world through sound signals — and a healthy person is able to recognize over 400,000 different sounds —preservation and restoration of the patient’s hearing is of particular importance for maintaining social activity in modern, informational conditions of the society development.

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