scholarly journals Role of Low Molecular Weight Heparin (LMWH) in the Treatment of Recurrent Missed Abortion

2016 ◽  
Vol 29 (2) ◽  
pp. 94-101
Author(s):  
Mosammat Rashida Begum ◽  
Mariya Ehsan ◽  
Nazia Ehsan ◽  
Iftekhar Amin ◽  
Farhana Sharmin ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Observational Study ◽  
Low Molecular Weight Heparin ◽  
Late Pregnancy ◽  
Live Birth Rate ◽  
Heparin Therapy ◽  
Fertility Treatment ◽  
Low Molecular Weight ◽  
Missed Abortion ◽  
Satisfactory Outcome

Objective (s): The aim of this study was to explore the outcome of treatment of low molecular weight heparin (LMWH) in recurrent missed abortion cases.Method: This prospective observational study was done between January 2005 and July 2014 in Infertility Care and Research Center, Dhaka, Bangladesh. Two hundred and ten (210) patients who were able to give clear history of missed abortion, who had no endocrine and hypertensive disorders and who conceived spontaneously or after fertility treatment were the target population for this study. After positive pregnancy test all patients started taking oral progesterone (Dydrogesterone 10 mg bd), folic acid and aspirin 75 mg daily. Patients were advised to come for ultrasonography at 6 weeks of pregnancy. After confirming intrauterine viable pregnancy by ultrasonography we started injection enoxaparin (LMWH) 40 mg sc daily to all patients and continued till 34 completed weeks. The primary end point was the live birth rate and secondary end points were the side effects, late pregnancy complications and neonatal outcome in the study population.Results: One hundred and nine (52.39%) patients had antiphospholipid syndrome. Among them antiphospholipid subgroup antibody found in 40.37% cases, ACLA found in 27.52% cases, LA found in 18.34% cases and both ACLA and LA found in 13.77% cases. Antinuclear antibody was positive in 10% cases. No abnormality was identified in 38.09% cases. Pregnancy continued successfully in 96.66% cases. There were no maternal and foetal complications. Except failed cases there was no need to discontinue the treatment.Conclusion: This observational study dealt only with recurrent missed abortion and found satisfactory outcome with low dose heparin therapy. Large, well-designed randomized trials are needed to establish the heparin therapy in recurrent missed abortion.Bangladesh J Obstet Gynaecol, 2014; Vol. 29(2) : 94-101

How Useful is the Monitoring of (Low Molecular Weight) Heparin Therapy by Anti-Xa Assay? A Laboratory Perspective

2005 ◽  
Vol 11 (3) ◽  
pp. 157-162 ◽  
Author(s):  
EMMANUEL J. FAVALORO ◽  
ROSLYN BONAR ◽  
MARGARET ABOUD ◽  
JOYCE LOW ◽  
JOHN SIOUFI ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Heparin Therapy ◽  
Low Molecular Weight

Self-Managed Long-Term Low-Molecular-Weight Heparin Therapy: The Balance of Benefits and Harms

2007 ◽  
Vol 120 (1) ◽  
pp. 72-82.e3 ◽  
Author(s):  
Russell D. Hull ◽  
Graham F. Pineo ◽  
Rollin F. Brant ◽  
Andrew F. Mah ◽  
Natasha Burke ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Heparin Therapy ◽  
Low Molecular Weight

scholarly journals Comparative study of low dose aspirin versus combination of low dose aspirin and low molecular weight heparin in idiopathic recurrent pregnancy loss

2020 ◽  
Vol 9 (2) ◽  
pp. 512
Author(s):  
S. Bhanu Rekha ◽  
K. Sharath Chandra
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Pregnancy Loss ◽  
Birth Rate ◽  
Low Dose ◽  
Recurrent Pregnancy Loss ◽  
Live Birth Rate ◽  
Low Molecular Weight ◽  
Dose Aspirin ◽  
Low Dose Aspirin

Background: To compare the role of low dose aspirin versus combination of low dose aspirin and low molecular weight heparin in idiopathic recurrent pregnancy loss and assess the effectiveness of low dose aspirin and low molecular weight heparin in having a better obstetric outcome.Methods: This study was conducted in a private hospital in Mahabubnagar from June 2017 to May 2019. A total of 80 pregnant ladies who had previous 2 and or more pregnancy losses in the early (before 20 weeks) or late (after 20 weeks) pregnancy period was included in the study. 80 pregnant women with idiopathic/unexplained recurrent pregnancy loss were properly evaluated in regard to the history of previous period of gestation of loss, previous scans in regard to documentation of fetal pole and gestation, cardiac activity, anomaly scan and growth scan and any special investigations in previous pregnancies and present pregnancy.Results: A total 80 pregnant women with previous 2 and more unexplained pregnancy losses who were evaluated and found negative with major causes of pregnancy losses half of them (40) were treated with low dose aspirin alone and the other 40 women were treated with a combination of low dose aspirin (75 mg) and low molecular weight Heparin (20 mg) daily low molecular weight heparin till term. The aspirin alone group had 82.5% live birth rate and the combination group had 92.5% live birth rate which is quite satisfactory and more than the Aspirin alone group.Conclusions: Use of combination of low dose aspirin and low molecular weight heparin seems to be a good choice of drugs in treating the unexplained recurrent pregnancy losses than low dose aspirin alone.

Dosing and monitoring of enoxaparin (Low molecular weight heparin) therapy in children

2010 ◽  
Vol 149 (5) ◽  
pp. 734-738 ◽  
Author(s):  
Vera Ignjatovic ◽  
Siti Najid ◽  
Fiona Newall ◽  
Robyn Summerhayes ◽  
Paul Monagle
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Heparin Therapy ◽  
Low Molecular Weight
Sign in / Sign up

Export Citation Format

Share Document