scholarly journals Non-invasive positive pressure ventilation offers greater improvement in COPD-related respiratory failure when combined with naloxone

2016 ◽  
Vol 11 (2) ◽  
pp. 359
Author(s):  
Long Zhang ◽  
Wei Zhao ◽  
Qinfu Xu ◽  
Yumiao Zhao ◽  
Junjie Zhao ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Pulmonary Function ◽  
Positive Pressure Ventilation ◽  
Respiratory Mechanics ◽  
Oxygen Metabolism ◽  
Positive Pressure ◽  
Control Group ◽  
Non Invasive ◽  
Copd Patients ◽  
New Treatment

<p class="Abstract">To improve efficacy of non-invasive positive pressure ventilation (NPPV), this study investigated the combination of NPPV with naloxone in COPD patients with respiratory failure. One hundred four patients with COPD-related respiratory failure were enrolled prospectively and randomly divided into a control group treated with NPPV alone (n = 52) and an observation group treated with NPPV combined with 4.0 mg naloxone by continuous infusion (n = 52). At 3 and 5 days after the start of treatment, the respiratory mechanics, pulmonary function, and oxygen metabolism parameters were significantly improved in the NPPV + naloxone group compared to the NPPV alone group (p&lt;0.05). Further, the improvements in the NPPV plus naloxone group were greater at day 5 than at day 3 (p&lt;0.05). These findings indicate that non-invasive positive pressure ventilation combined with naloxone can more effectively improve respiratory mechanics, pulmonary function and oxygen metabolism of COPD patients with respiratory failure than NPPV alone, offering a new treatment approach.</p><p> </p>

scholarly journals Predictors for long‐term mortality in COPD patients requiring non‐invasive positive pressure ventilation for the treatment of acute respiratory failure

2020 ◽  
Vol 14 (12) ◽  
pp. 1144-1152 ◽  
Author(s):  
Roy T. M. Sprooten ◽  
Gernot G. U. Rohde ◽  
Marlou T. H. F. Janssen ◽  
Nicolle A. M. Cobben ◽  
Emiel F. M. Wouters ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Positive Pressure Ventilation ◽  
Positive Pressure ◽  
Non Invasive ◽  
Copd Patients ◽  
Long Term Mortality

scholarly journals The Effect of a Non-Invasive Positive Pressure Ventilation Simulation Program on General Ward Nurses’ Knowledge and Self-Efficacy

2021 ◽  
Vol 18 (6) ◽  
pp. 2877
Author(s):  
Moon-Sook Kim ◽  
Mi-Hee Seo ◽  
Jin-Young Jung ◽  
Jinhyun Kim
Keyword(s):  
Self Efficacy ◽  
Qualitative Data ◽  
Positive Pressure Ventilation ◽  
Intervention Group ◽  
General Ward ◽  
Simulation Program ◽  
Positive Pressure ◽  
Control Group ◽  
Training Strategy ◽  
Non Invasive

The purpose of this study is to develop a simulation-based ventilator training program for general ward nurses and identify its effects. Quantitative data were collected from 29 nurses (intervention group: 15, control group: 14), of which seven were interviewed with focus groups to collect qualitative data. The quantitative results revealed significant differences in ventilator-related knowledge (p = 0.029) and self-efficacy (p = 0.026) between the intervention and control groups. Moreover, three themes were derived from meaningful statements in the qualitative data: understanding psychophysical discomfort of the patient while applying the ventilator; helping in ventilator care; and establishing a future ventilator training strategy. The findings confirmed that the non-invasive positive pressure ventilation (NPPV) simulation program is an effective method for improving the knowledge of ventilator nursing and self-efficacy and will be helpful in developing educational methods and strategies related to ventilator nursing for general ward nurses.

scholarly journals Non-invasive positive pressure ventilation in acute hypercapnic respiratory failure: clinical experience of a respiratory ward

2004 ◽  
Vol 61 (2) ◽  
Author(s):  
R. Scala ◽  
M. Naldi ◽  
I. Archinucci ◽  
G. Coniglio
Keyword(s):  
Clinical Practice ◽  
Respiratory Failure ◽  
Standard Therapy ◽  
Positive Pressure Ventilation ◽  
Controlled Trial ◽  
Positive Pressure ◽  
Hypercapnic Respiratory Failure ◽  
Non Invasive ◽  
Arterial Blood ◽  
Acute Hypercapnic Respiratory Failure

Background: Although a controlled trial demonstrated that non-invasive positive pressure ventilation (NIV) can be successfully applied to a respiratory ward (RW) for selected cases of acute hypercapnic respiratory failure (AHRF), clinical practice data about NIV use in this setting are limited. The aim of this observational study is to assess the feasibility and efficacy of NIV applied to AHRF in a RW in everyday practice. Methods: Twenty-two percent (216/984) of patients consecutively admitted for AHRF to our RW in Arezzo (years: 1996-2003) received NIV in addition to standard therapy, according to pre-defined routinely used criteria. Tolerance, effects upon arterial blood gases (ABG), success rate (avoidance a priori criteria for intubation) and predictors of failure of NIV were analysed. Results: Nine patients (4.2%) were found to be intolerant to NIV, while the remaining 207 (M: 157, F: 50; mean (SD) age: 73.2 (8.9) yrs; COPD: 71.5%) were ventilated for &gt;1 hour. ABG significantly improved after two hours of NIV (pH: 7.32 (0.06) versus median (Interquartiles) 7.28 (7.24-7.31), p&lt;0.0001; PaCO2: 71.9 (13.5) mmHg versus 80.0 (15.2) mmHg, p&lt;0.0001; PaO2/FiO2: 212 (66) versus 184 (150-221), p&lt;0.0001). NIV succeeded in avoiding intubation in 169/207 patients (81.6%) with hospital mortality of 15.5%. NIV failure was independently predicted by Activity of Daily Living score, pneumonia as cause of AHRF and Acute Physiology and Chronic Health Evaluation III score. Conclusions: In clinical practice NIV is feasible, effective in improving ABG and useful in avoiding intubation in most AHRF episodes that do not respond to the standard therapy managed in an RW adequately trained in NIV.

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