scholarly journals Mouse model of DNCB-induced atopic dermatitis

2017 ◽  
Vol 12 (2) ◽  
pp. 30
Author(s):  
Alshammari Fanar Hamad ◽  
Jong-Hun Han ◽  
Irfan Ahmad Rather
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Video Clip ◽  
Skin Inflammation ◽  
New Drugs ◽  
Dorsal Skin ◽  
Reference Drug ◽  
Allergic Skin ◽  
Full Screen ◽  
Selection Of

<p>Atopic dermatitis is a skin disease characterized by allergic skin inflammation, redness and itching. The animal model is necessary to find out new drugs. The DNCB-induced animal model of atopic dermatitis includes the following steps: 1) Selection of animals; 2) Shaving of dorsal skin; 3) Applying DNCB once in 24 hours for three days; 4) Monitoring the development of atopy on day 4 post DNCB application. Further, the efficacy of reference drug can be determined by applying on the atopy skin, depends on the nature and aim of the work.</p><p><strong>Video Clip of Methodology</strong>: 8 min   <a href="https://www.youtube.com/v/XbFt1bOnulc">Full Screen</a>   <a href="https://www.youtube.com/watch?v=XbFt1bOnulc">If Failed</a></p>

scholarly journals Imiquimod-induced psoriasis-like skin inflammation in mouse model

2016 ◽  
Vol 11 (4) ◽  
pp. 849 ◽  
Author(s):  
Irfan Ahmad Rather ◽  
Vivek K. Bajpai ◽  
Jonghun Han ◽  
Gyeong-Jun Nam
Keyword(s):  
Animal Model ◽  
Mouse Model ◽  
Skin Disorder ◽  
Video Clip ◽  
Skin Inflammation ◽  
Selection Of

<p>Psoriasis is a skin disorder characterized by skin inflammation and plaques. Induction of psoriasis in animal model include following steps: a) Selection of animal model, b) Hair removing from the back or ear, c) treatment of skin with Aldara, a cream containing 5% imiquimod and d) Observation. Imiquimod-induced skin inflammation in animal model resembles with psoriasis.</p><p><strong>Video Clip:</strong></p><p><a href="https://youtube.com/v/QY-RESHbH-U">Psoriaisis-like skin:</a> 9 min 10 sec</p>

scholarly journals The modern aspects of atopic dermatitis pathogenesis in children

2009 ◽  
Vol 7 (5) ◽  
pp. 48-57
Author(s):  
A V Kudryavtseva
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Mast Cells ◽  
Skin Inflammation ◽  
Pathological Process ◽  
Pathogenic Factors ◽  
Allergic Skin ◽  
Antigen Presenting ◽  
Modern Russian

The article analyzes the results obtained by modern Russian and foreign researchers who focused on the pathogenic factors responsible for the appearance and the development of atopic dermatitis. The reasons for skin dryness appearance, the mechanisms of itch development, the immune system role in allergic skin inflammation: the involvement of lymphocytes, antigen presenting sells, mast cells, basophiles and eosinophiles into the pathological process have been thoroughly observed. The causes contributing to atopic dermatitis development and triggering disease aggravation have been described.

scholarly journals APRIL expression is upregulated in atopic dermatitis skin lesions and at sites of antigen driven allergic skin inflammation in mice

2020 ◽  
Vol 219 ◽  
pp. 108556
Author(s):  
Juan Manuel Leyva-Castillo ◽  
Haifa H. Jabara ◽  
Joerg Wenzel ◽  
Alex McGurk ◽  
Daniel Wong ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Inflammation ◽  
Skin Lesions ◽  
Allergic Skin

scholarly journals Atopic dermatitis: experimentalmodels for study of pathogenesis and development of new methods of treatment

2011 ◽  
Vol 8 (6) ◽  
pp. 3-11
Author(s):  
N N Shershakova ◽  
A A Babakhin ◽  
O G Elisyutina ◽  
M R Khaitov ◽  
N N Shershakova ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Skin Inflammation ◽  
Barrier Dysfunction ◽  
Skin Injury ◽  
Allergic Skin ◽  
Promising Area ◽  
Functional Peptides ◽  
Methods Of Treatment

Atopic dermatitis (AD) is characterized by allergic skin inflammation. A hallmark of AD is dry itchy skin due, at least in part, to defects in skin genes that are important for maintaining barrier function. The pathogenesis of AD remains incompletely understood. A number of mouse models of AD have been developed. This review discusses these models and emphasizes the role of mechanical skin injury and skin barrier dysfunction in eliciting allergic skin inflammation. Also, we describe various approaches to the treatment of atopic dermatitis, the latest of which is the introduction of siRN A. Development of drugs based on siRN A using functional peptides is a promising area of research in allergology.

scholarly journals Synthesis of 4-aryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyridines as novel skin protecting and anti-aging agents

2017 ◽  
Vol 12 (2) ◽  
pp. 25 ◽  
Author(s):  
Aamer Saeed ◽  
Danish Shahzad ◽  
Fayaz Ali Larik ◽  
Pervaiz Ali Channar ◽  
Haroon Mahfooz ◽  
...  
Keyword(s):  
Radical Scavenging Activity ◽  
Video Clip ◽  
Radical Scavenging ◽  
Aromatic Aldehydes ◽  
One Pot ◽  
Reference Drug ◽  
Full Screen ◽  
Ft Ir ◽  
The One ◽  
Almost All

<p>A series of 4-aryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyri-dines 6a-6h were prepared by using the one-pot three component synthetic method. The target compounds 6a-6h were synthesized by reacting two molar equivalents of ketone functionality and one mole of aromatic aldehydes in ammonium acetate to obtain the desired products. The structures of newly synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR, and elemental analysis. All the synthesized compounds were screened for their elastase inhibition and antioxidant activity. Almost all of the com-pounds 6a-h showed good to excellent activities against elastase enzyme more than the reference drug. Compounds 6d and 6b at 0.2 ± 0.0 µM and 0.2 ± 0.0 µM were found to most potent derivatives against elastase enzyme. Compound 6a exhibited prominent free radical scavenging activity. From the results of the biological activity, we infer that some derivatives can serve as lead molecules in pharmacology.</p><p><strong>Video Clip of Methodology</strong>:</p><p>3 min 13 sec   <a href="https://youtube.com/v/gPLdpGpZhR8">Full Screen</a>   <a href="https://youtube.com/watch?v=gPLdpGpZhR8">Alternate</a></p>

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