scholarly journals One pot synthesis of Biginelli 3,4-dihydro-1H-pyrimidin-2-ones and 1,2,3,4-tetrahydro pyrimidines

2020 ◽  
Vol 55 (3) ◽  
pp. 173-180
Author(s):  
Md E Halim ◽  
K Akhter ◽  
SM Ahmed ◽  
Md Al Amin Hossain ◽  
UKR Romman
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Ethyl Acetoacetate ◽  
Nmr Spectra ◽  
13C Nmr Spectra ◽  
One Pot ◽  
One Pot Synthesis ◽  
Elemental Analyses ◽  
Cyclocondensation Reaction ◽  
Anhydrous Zncl2

A simple and practical route for the Biginelli cyclocondensation reaction using anhydrous ZnCl2 as a catalyst in n-heptane-toluene medium by reaction of substituted benzaldehydes,1a-d (1a=2-ClC6H4-, 1b=2-BrC6H4- and 1c=4-ClC6H4-,1d=2-H3CC6H4-) with 1, 3-dicarbonyl compounds, 2a-b (2a= ethyl acetoacetate and 2b= acetylacetone) and urea or thiourea, 3a-b to give the corresponding Biginelli 3,4-dihydro- 1H-pyrimidin-2-ones and 1,2,3,4-tetrahydro pyrimidines, 4a-d. The structures of the compounds 4a-d were confirmed by their ultraviolet, infrared, 1H NMR, 13C NMR spectra and elemental analyses. Bangladesh J. Sci. Ind. Res.55(3), 173-180, 2020

Synthesis of 2,2`-(1,4-Phenylene)bis-3,4-dihydro-2H-1,3-thiazin-4-ones and their Facile Recyclization to 2,2`-(1,4-Phenylene)bis(pyrimidin-4-one) and/or 2,2`-(1,4-Phenylene)-bis-(thieno[2,3-d]pyrimidin-4(1H)-one) Derivatives

2010 ◽  
Vol 65 (9) ◽  
pp. 1148-1154 ◽  
Author(s):  
Raafat M. Shaker ◽  
Yusria R. Ibrahim ◽  
Fathy F. Abdel-Latif ◽  
Asmaa Hamoda
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Nmr Spectra ◽  
13C Nmr Spectra ◽  
Elemental Analyses

An efficient and direct procedure for the synthesis of 2,2`-(1,4-phenylene)bis-3,4-dihydro-2H-1,3- thiazin-4-one derivatives is described. Oxidation of the latter and their base-catalyzed recyclization has been studied. The products were characterized by elemental analyses, and IR, 1H NMR, and 13C NMR spectra.

scholarly journals A New Derivatives of Benzodiazepine, Imidazole, Isatin, Maleimide, Pyrimidine and 1,2,4-Triazole: Synthesis and Characterization

2008 ◽  
Vol 5 (2) ◽  
pp. 305-312
Author(s):  
Baghdad Science Journal
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Synthesis And Characterization ◽  
13C Nmr Spectra ◽  
Organic Reagents ◽  
Cyclocondensation Reaction ◽  
Heterocyclic Derivatives ◽  
Ft Ir ◽  
Derivatives Of

The synthesis of new benzodiazepine, imidazole, isatin, maleimide, pyrimidine and 1,2,4-triazole derived from 2-amino-4-hydroxy-1,3,5-triazine, via its cyclocondensation reaction with different organic reagents, is described. FT-IR, 1H-NMR and as well as 13C-NMR spectra disclosed the structures of the precursors and heterocyclic derivatives formed.

5-Aminouracil as a Building Block in Heterocyclic Synthesis, Part II. One-pot Synthesis of Pyrido[3,2-d:6,5-dʹ]dipyrimidines under Microwave Irradiation without Catalyst

2009 ◽  
Vol 64 (10) ◽  
pp. 1193-1198 ◽  
Author(s):  
Raafat M. Shaker ◽  
Mohamed A. Ameen ◽  
Afaf M. Abdel Hameed ◽  
Mohamed Abd Elrady
Keyword(s):  
Microwave Irradiation ◽  
1H Nmr ◽  
13C Nmr ◽  
Building Block ◽  
Heterocyclic Synthesis ◽  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
Elemental Analyses

An efficient and direct procedure for the synthesis of pyrido[3,2-d:6,5-dʹ]dipyrimidine derivatives under microwave-assisted conditions is been described. The structures of the products were characterized by elemental analyses, and their IR, 1H NMR, 13C NMR, and MS spectra.

Benzimidazole Derivatives as Potential Antimicrobial and Antiulcer Agents: A Mini Review

2019 ◽  
Vol 19 (16) ◽  
pp. 1292-1297 ◽  
Author(s):  
Ali Mohd Ganie ◽  
Ayaz Mahmood Dar ◽  
Fairooz Ahmad Khan ◽  
Bashir Ahmad Dar
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
1H Nmr ◽  
13C Nmr ◽  
Benzimidazole Derivatives ◽  
Spectroscopic Techniques ◽  
One Pot ◽  
Biological Screening ◽  
Elemental Analyses ◽  
Characterization Studies

:Here in we report the number of strategies for the synthesis of differently substituted benzimidazole derivatives. The protocols involved in the syntheses of these derivatives were one-pot or multi-component. The characterization studies of these derivatives were carried by using different spectroscopic techniques (1H NMR, 13C NMR and MS) and elemental analyses. The biological screening studies revealed that these benzimidazole derivatives show potential antibacterial as well as antifungal behavior. These benzimidazole derivatives not only depicted potential antiulcer properties but also showed moderate to good anticancer/cytotoxic behavior against different cancer cell lines.

Partial least squares modeling of combined infrared, 1H NMR and 13C NMR spectra to predict long residue properties of crude oils

2009 ◽  
Vol 51 (2) ◽  
pp. 205-212 ◽  
Author(s):  
Peter de Peinder ◽  
Tom Visser ◽  
Derek D. Petrauskas ◽  
Fabien Salvatori ◽  
Fouad Soulimani ◽  
...  
Keyword(s):  
Least Squares ◽  
Partial Least Squares ◽  
1H Nmr ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Crude Oils ◽  
13C Nmr Spectra

Synthesis and Characterization of N-butyl-N-methylimidazolium- D-(-)-tartrate Chiral Ionic Liquid

2012 ◽  
Vol 518-523 ◽  
pp. 3989-3992 ◽  
Author(s):  
Yang Zhang ◽  
Xiao Hua Tu ◽  
Cheng Ping Miao ◽  
Jian Yi Wu
Keyword(s):  
Ionic Liquid ◽  
1H Nmr ◽  
Ion Chromatography ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Optical Rotation ◽  
Synthesis And Characterization ◽  
13C Nmr Spectra ◽  
Chiral Ionic Liquid

A novel CIL of N-butyl-N-methyl imidazolium-D-(-)-tartrate has been designed and synthesized by neutralization reaction. Its structure was characterized by 1H-NMR and 13C-NMR spectra, the optical rotation was characterized by polarimeter with the value of-15.0º, and the purity was characterized by ion chromatography with the value of 98.4%.

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