scholarly journals Effect of Hydrophobic Polymers on the Gastro Retention Time and In vitro Release of Ciprofloxacin HCl from Co-matrix Tablets

1970 ◽  
Vol 9 (2) ◽  
pp. 97-102
Author(s):  
Muhammad Shahidul Islam ◽  
Kumar Bishwajit Sutradhar ◽  
Jakir Ahmed Chowdhury ◽  
Md Selim Reza
Keyword(s):  
Adhesive Strength ◽  
Retention Time ◽  
Xanthan Gum ◽  
Water Soluble ◽  
Matrix Tablets ◽  
Direct Compression ◽  
Eudragit Rs ◽  
Water Soluble Drug ◽  
Eudragit Rs Po

The present study was conducted to investigate the effect of different polymers on the release profile and bio-adhesive strength of a water soluble drug, ciprofloxacin HCl from different percentages of Eudragit RS PO and Kollidon SR based co-matrix tablets. Matrix formulations were prepared by direct compression method. The bioadhesive property was investigated in terms of retention time following in vitro wash-off method. The concentrations of polymers were varied to investigate whether these variations can cause any change in release of ciprofloxacin HCl molecule and bio-adhesion property or not. In most of the cases it is found that Eudragit RS PO based co-matrix tablets release greater percentage of active drug and that bio-adhesive strength of Kollidon SR and xanthan gum based co-matrix tablets were significantly better. Finally it was revealed that xanthan gum provided optimum bioadhesion functioning as a synergist in co-matrices and comply the USP specification as a most suitable controlled release polymer. Key words: Gastro retention time; direct compression; ciprofloxacin HCl; Eudragit RS PO; Kollidon SR; xanthan gum. DOI: http://dx.doi.org/10.3329/dujps.v9i2.7893 Dhaka Univ. J. Pharm. Sci. 9(2): 97-102, 2010 (December)

scholarly journals Comparison of Gastro Retention Time and in vitro Release Profile studies of Ciprofloxacin HCl from Co-matrix Tablets of Hydrophilic Polymers

1970 ◽  
Vol 8 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Muhammad Shahidul Islam ◽  
Kazi Rashidul Azam ◽  
Jakir Ahmed Chowdury ◽  
Md Selim Reza
Keyword(s):  
Retention Time ◽  
Xanthan Gum ◽  
Gastric Fluid ◽  
Matrix Tablets ◽  
Drug Dissolution ◽  
Simulated Gastric Fluid ◽  
Burst Release ◽  
Direct Compression ◽  
Zero Order Release

Controlled release co-matrix tablets of Ciprofloxacin HCl were prepared with different types of bioadhesivepolymers e.g. Methocel K4M, Methocel K 15M CR and Methocel K 100LV, Povidone K-30, and Xanthangum. Tablets prepared by direct compression method were subjected to in-vitro drug dissolution study for 8 hours ina simulated gastric fluid media using USP dissolution apparatus II with 50 rpm at 37±0.5ºC. The bio-adhesiveproperty was investigated in terms of retention time following in-vitro wash-off method. The concentrations ofpolymers were varied to investigate whether these variations can cause any change in release of Ciprofloxacin HClmolecule and bio-adhesion property or not. In most of the cases it is found that Methocel K4M and MethocelK100LV based co-matrix tablets release greater percentage of active drug than Methocel K15M CR based co-matrixtablets. Bio-adhesive strength of Methocel K15M CR and Xanthan gum based co-matrix tablets was proved to bemaximum followed by Methocel K4M and Xanthan gum based co-matrices. Whereas Methocel K100LV andXanthan gum based co-matrices showed little or poor muco-adhesion. Methocel K4M, K15M CR and Xanthan gumbased formulations showed nearly zero-order release, on the other hand Methocel K100LV and Xanthan gum basedformulation showed a burst release within one hour of dissolution. Finally it was revealed that Xanthan gum providedoptimum bio-adhesion functioning as a synergist in co-matrices and comply the USP specification as a most suitablecontrolled release polymer.Key words: Gastro retention time; Direct Compression; Ciprofloxacin HCl; Methocel K4M; Methocel K15M CR;Methocel K100LV; Xanthan gum.DOI: 10.3329/dujps.v8i1.5338Dhaka Univ. J. Pharm. Sci. 8(1): 67-73, 2009 (June)

scholarly journals In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug

2016 ◽  
Vol 52 (4) ◽  
pp. 751-759 ◽  
Author(s):  
Wendy Leticia Guerra-Ponce ◽  
Sandra Leticia Gracia-Vásquez ◽  
Patricia González-Barranco ◽  
Ivonne Antonieta Camacho-Mora ◽  
Yolanda Araceli Gracia-Vásquez ◽  
...  
Keyword(s):  
Water Soluble ◽  
Matrix Tablets ◽  
In Vitro Evaluation ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

scholarly journals In vitro Release Kinetic Study of Theophylline from Eudragit RS PO and Eudragit RL PO Matrix Tablets

1970 ◽  
Vol 8 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Apurba Sarker Apu ◽  
Atiqul Haque Pathan ◽  
Golam Kibria ◽  
Reza-ul Jalil
Keyword(s):  
Release Rate ◽  
Release Kinetics ◽  
Matrix Tablets ◽  
Release Kinetic ◽  
Matrix Tablet ◽  
Eudragit Rs ◽  
Zero Order Release ◽  
Eudragit Rl ◽  
Eudragit Rs Po

The aim of the present study was to investigate the release kinetics of theophylline from permeableacrylic polymer matrix tablets. Matrix tablets were prepared by direct compression method using Eudragit RS PO andEudragit RL PO. Two batches of matrix tablets were prepared. Only Eudragit RS PO was used in the first batch, andin the second batch both Eudragit RS PO and Eudragit RL PO were used as the rate retarding polymers in differentproportions. The variation of hardness was insignificant in batches. Drug release was investigated by using USPbasket method and the results of release rates were analyzed by using correlation coefficient value of Zero orderrelease plot & Higuchi plot and exponent value of Bi-exponential release profile. Theophylline tablets having onlyEudragit RS PO showed comparatively slow release but release rate improved significantly as seen in formulationscontaining Eudragit RL PO and Eudragit RS PO. It was also revealed that, in all cases the release of theophyllinefollowed mixed release kinetics where Zero order release kinetics was predominant.Key words: Sustained release; matrix tablet; theophylline; acrylic polymers; eudragit; release rate; dissolution;hardness.DOI: 10.3329/dujps.v8i1.5328Dhaka Univ. J. Pharm. Sci. 8(1): 1-6, 2009 (June)

Controlled Release of Metformin Hydrochloride I. In vitro Release from Physical Mixture Containing Xanthan Gum as Hydrophilic Rate Retarding Polymer

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Mashkura Ashrafi ◽  
Jakir Ahmed Chowdhury ◽  
Md Selim Reza
Keyword(s):  
Controlled Release ◽  
Xanthan Gum ◽  
In Vitro Release ◽  
Correlation Coefficients ◽  
High Ratio ◽  
Water Soluble ◽  
Metformin Hydrochloride ◽  
Model Drug ◽  
Very High

Capsules of different formulations were prepared by using a hydrophilic polymer, xanthan gum and a filler Ludipress. Metformin hydrochloride, which is an anti-diabetic agent, was used as a model drug here with the aim to formulate sustained release capsules. In the first 6 formulations, metformin hydrochloride and xanthan gum were used in different ratio. Later, Ludipress was added to the formulations in a percentage of 8% to 41%. The total procedure was carried out by physical mixing of the ingredients and filling in capsule shells of size ‘1’. As metformin hydrochloride is a highly water soluble drug, the dissolution test was done in 250 ml distilled water in a thermal shaker (Memmert) with a shaking speed of 50 rpm at 370C &plusmn 0.50C for 6 hours. After the dissolution, the data were treated with different kinetic models. The results found from the graphs and data show that the formulations follow the Higuchian release pattern as they showed correlation coefficients greater than 0.99 and the sustaining effect of the formulations was very high when the xanthan gum was used in a very high ratio with the drug. It was also investigated that the Ludipress extended the sustaining effect of the formulation to some extent. But after a certain period, Ludipress did not show any significant effect as the pores made by the xanthan gum network were already blocked. It is found here that when the metformin hydrochloride and the xanthan gum ratio was 1:1, showed a high percentage of drug release, i.e. 91.80% of drug was released after 6 hours. But With a xanthan gum and metformin hydrochloride ratio of 6:1, a very slow release of the drug was obtained. Only 66.68% of the drug was released after 6 hours. The percent loading in this case was 14%. Again, when Ludipress was used in high ratio, it was found to retard the release rate more prominently. Key words: Metformin Hydrochloride, Xanthan Gum, Controlled release capsule Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

Formulation and Evaluation of Galantamine Hydrobromide Floating Matrix Tablet

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Poreddy Srikanth Reddy ◽  
Penjuri Subhash Chandra Bose ◽  
Vuppula Sruthi ◽  
Damineni Saritha
Keyword(s):  
Sodium Alginate ◽  
Xanthan Gum ◽  
Lag Time ◽  
Matrix Tablets ◽  
In Vitro Dissolution ◽  
Matrix Tablet ◽  
Compression Technique ◽  
Weight Variation ◽  
The Matrix

The aim of the present work was to prepare floating tablets of galantamine HBr using sodium alginate and xanthan gum as matrix forming carriers. Galantamine HBr is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments, in particular those of vascular origin. The matrix tablet formulations were prepared by varying the concentrations of sodium alginate and xanthan gum. The tablets were prepared by direct compression technique using PVP K-30 as a binder and sodium bicarbonate for development of CO2. The prepared matrix tablets were evaluated for properties such as hardness, thickness, friability, weight variation, floating lag time, compatibility using DSC and FTIR. In vitro dissolution was carried out for 12 hrs in 0.1N HCl at 37±0.5 ºC using USP paddle type dissolution apparatus. It was noted that, all the prepared formulations had desired floating lag time and constantly floated on dissolution medium by maintaining the matrix integrity. The drug release from prepared tablets was found to vary with varying concentration of the polymers, sodium alginate and xanthan gum. From the study it was concluded that floating drug delivery system for galantamine HBr can be prepared by using sodium alginate and xanthan gum as a carrier.

Development and Evaluation of Controlled Release Mucoadhesive Tablets of Captopril

1970 ◽  
Vol 9 (3) ◽  
pp. 3318-3329
Author(s):  
Kranthi Kumar Kotta ◽  
L. Srinivas
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Xanthan Gum ◽  
Diffusion Mechanism ◽  
Matrix Tablets ◽  
Fickian Diffusion ◽  
Content Uniformity ◽  
In Vitro Drug Release ◽  
Mucoadhesive Tablets

The present investigation focuses on the development of mucoadhesive tablets of captopril which are designed to prolong the gastric residence time after oral administration. Matrix tablets of captopril were formulated using four mucoadhesive polymers namely guar gum, xanthan gum, HPMC K4M and HPMC K15M and studied for parameters such as weight variation, thickness, hardness, content uniformity, swelling index, mucoadhesive force and in vitro drug release. Tablets formulated Xanthan gum or HPMC K4M with HPMC K15M provide slow release of captopril over period of 12 hr and were found suitable for maintenance portion of oral controlled release tablets. The cumulative % of drug release of formulation F9 and F10 were 90 and 92, respectively. In vitro release from these tablets was diffusion controlled and followed zero order kinetics. The ‘n’ values obtained from the pappas-karsemeyer equation suggested that all the formulation showed drug release by non-fickian diffusion mechanism. Tablets formulated Xanthan gum or HPMC K4M with HPMC K15M (1:1) were established to be the optimum formulation with optimum bioadhesive force, swelling index & desired invitro drug release. This product was further subjected to stability study, the results of which indicated no significant change with respect to Adhesive strength and in vitro drug release study.

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