scholarly journals Natural Polymers in ihe Development of Floating Drug Delivery Systems: A Review

2013 ◽  
Vol 2 (4) ◽  
pp. 165-178 ◽  
Author(s):  
Kumar Ganesh ◽  
Dhyani Archana ◽  
Kothiyal Preeti
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Special Focus ◽  
Polymer Science ◽  
Natural Polymers ◽  
Principal Mechanism ◽  
Floating Drug Delivery ◽  
Wide Range ◽  
Floating Drug Delivery Systems

The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention . This can be achieved by use of various polymeric substances including natural polymers. These polymers are inexpensive, safe and available in a variety of structures with versatile characteristics. Large number of derivatizable groups, wide range of molecular weights, varying chemical composition gel forming nature of these polymers also provide an exciting opportunities in the fascinating arena of applied polymer science and drug delivery technology. All these characteristics make them suitable candidate for design and fabrication of novel gastroretentive drug delivery systems. Various natural polymers have been investigated worldwide by scientific community for their potential as floating drug delivery systems. The present article highlights various recent efforts and advanced approaches exploiting several natural polymers in this technology. DOI: http://dx.doi.org/10.3329/ijpls.v2i4.17116 International Journal of Pharmaceutical and Life Sciences Volume 2, Issue 4: October 2013; 165-178

scholarly journals Floating drug delivery systems: A better approach

2012 ◽  
Vol 1 (5) ◽  
pp. 119-127 ◽  
Author(s):  
Abhishek Chandel ◽  
Kapil Chauhan ◽  
Bharat Parashar ◽  
Hitesh Kumar ◽  
Sonia Arora
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Pharmaceutical Journal ◽  
Delivery Systems ◽  
Special Focus ◽  
Gastric Retention ◽  
Principal Mechanism ◽  
Floating Drug Delivery ◽  
Floating Systems ◽  
Floating Drug Delivery Systems

The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. It is known that differences in gastric physiology (such as, gastric pH, motility) exhibit both intra- as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behaviour. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the studies to evaluate the performance and application of floating systems, and applications of these systems.DOI: http://dx.doi.org/10.3329/icpj.v1i5.10283International Current Pharmaceutical Journal 2012, 1(5): 110-118

scholarly journals Floating drug delivery system- a review

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Sharma Anjali ◽  
Sharma Devkant
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gastric Retention ◽  
Residence Times ◽  
Principal Mechanism ◽  
Floating Drug Delivery ◽  
Floating Systems ◽  
Floating Drug Delivery Systems

In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming various physiological problems such as short gastric residence times and unpredictable gastric emptying times. Several approaches are utilized in the prolongation of the gastric residence times, such as floating drug delivery systems, swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. Floating Drug Delivery Systems (FDDS) is one amongst the GRDFs used to achieve prolonged gastric residence time. The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in-vitro techniques, in- vivo studies to evaluate the performance and application of floating systems, and applications of these systems.

scholarly journals Interpenetrating Polymer Networks as Innovative Drug Delivery Systems

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Alka Lohani ◽  
Garima Singh ◽  
Shiv Sankar Bhattacharya ◽  
Anurag Verma
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymer Networks ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Interpenetrating Polymer Networks ◽  
Bioactive Molecules ◽  
Polymer Science ◽  
Natural Polymers ◽  
Innovative Drug

Polymers have always been valuable excipients in conventional dosage forms, also have shown excellent performance into the parenteral arena, and are now capable of offering advanced and sophisticated functions such as controlled drug release and drug targeting. Advances in polymer science have led to the development of several novel drug delivery systems. Interpenetrating polymer networks (IPNs) have shown superior performances over the conventional individual polymers and, consequently, the ranges of applications have grown rapidly for such class of materials. The advanced properties of IPNs like swelling capacity, stability, biocompatibility, nontoxicity and biodegradability have attracted considerable attention in pharmaceutical field especially in delivering bioactive molecules to the target site. In the past few years various research reports on the IPN based delivery systems showed that these carriers have emerged as a novel carrier in controlled drug delivery. The present review encompasses IPNs, their types, method of synthesis, factors which affects the morphology of IPNs, extensively studied IPN based drug delivery systems, and some natural polymers widely used for IPNs.

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