A Review on Gastro Retentive Drug Delivery Systems with the Special Focus on Floating Drug Delivery

Oral route has been the most convenient and accepted route of drug delivery. Owing to tremendous curative benefits of the oral controlled release dosage forms are being preferred as the interesting topic in pharmaceutical field to achieved improved therapeutics advantages. Gastro retentive drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also improves bioavailability of drugs. Concept of novel drug delivery system arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. In this context, various gastro retentive drug delivery systems have been used to improve the therapeutic efficacy of drugs that have a narrow absorption window, are unstable at alkaline pH, are soluble in acidic conditions, and are active locally in the stomach. Concept of novel drug delivery system arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. Various approaches are currently used including gastro retentive floating drug delivery systems, swelling and expanding system, polymeric bio adhesive systems, modified shape systems, high density system and other delayed gastric emptying devices. Moreover, future perspectives on this technology are discussed to minimize the gastric emptying rate in both the fasted and fed states. The present review briefly addresses the physiology of the gastric emptying process with respect to floating drug delivery systems. The purpose of this review is to bring together the recent literature with respect to the method of preparation, and various parameters affecting the performance and characterization of floating microspheres. Attempt has been made to summarize important factors controlling gastro retentive drug delivery systems. Overall, this review may inform and guide formulation scientists in designing the gastro retentive drug delivery system.

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A Comprehensive Review on Gastro-Retentive Floating Drug Delivery Systems

Asian Journal of Pharmaceutical Research ◽

10.5958/2231-5691.2015.00033.7 ◽

2015 ◽

Vol 5 (4) ◽

pp. 211

Author(s):

Zope S. Janhavi ◽

Sonawane L. Pradnya ◽

A. B. Darekar ◽

R.B. Saudagar

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Comprehensive Review ◽

Floating Drug Delivery ◽

Floating Drug Delivery Systems ◽

Gastro Retentive

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Natural Polymers in ihe Development of Floating Drug Delivery Systems: A Review

International Journal of Pharmaceutical and Life Sciences ◽

10.3329/ijpls.v2i4.17116 ◽

2013 ◽

Vol 2 (4) ◽

pp. 165-178 ◽

Cited By ~ 1

Author(s):

Kumar Ganesh ◽

Dhyani Archana ◽

Kothiyal Preeti

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Special Focus ◽

Polymer Science ◽

Natural Polymers ◽

Principal Mechanism ◽

Floating Drug Delivery ◽

Wide Range ◽

Floating Drug Delivery Systems

The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention . This can be achieved by use of various polymeric substances including natural polymers. These polymers are inexpensive, safe and available in a variety of structures with versatile characteristics. Large number of derivatizable groups, wide range of molecular weights, varying chemical composition gel forming nature of these polymers also provide an exciting opportunities in the fascinating arena of applied polymer science and drug delivery technology. All these characteristics make them suitable candidate for design and fabrication of novel gastroretentive drug delivery systems. Various natural polymers have been investigated worldwide by scientific community for their potential as floating drug delivery systems. The present article highlights various recent efforts and advanced approaches exploiting several natural polymers in this technology. DOI: http://dx.doi.org/10.3329/ijpls.v2i4.17116 International Journal of Pharmaceutical and Life Sciences Volume 2, Issue 4: October 2013; 165-178

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Floating drug delivery systems: A better approach

International Current Pharmaceutical Journal ◽

10.3329/icpj.v1i5.10283 ◽

2012 ◽

Vol 1 (5) ◽

pp. 119-127 ◽

Cited By ~ 14

Author(s):

Abhishek Chandel ◽

Kapil Chauhan ◽

Bharat Parashar ◽

Hitesh Kumar ◽

Sonia Arora

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Pharmaceutical Journal ◽

Delivery Systems ◽

Special Focus ◽

Gastric Retention ◽

Principal Mechanism ◽

Floating Drug Delivery ◽

Floating Systems ◽

Floating Drug Delivery Systems

The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. It is known that differences in gastric physiology (such as, gastric pH, motility) exhibit both intra- as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behaviour. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the studies to evaluate the performance and application of floating systems, and applications of these systems.DOI: http://dx.doi.org/10.3329/icpj.v1i5.10283International Current Pharmaceutical Journal 2012, 1(5): 110-118

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Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

Current Topics in Medicinal Chemistry ◽

10.2174/1568026618666180608125344 ◽

2018 ◽

Vol 18 (10) ◽

pp. 857-880 ◽

Cited By ~ 3

Author(s):

Salma E. Ahmed ◽

Nahid Awad ◽

Vinod Paul ◽

Hesham G. Moussa ◽

Ghaleb A. Husseini

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Special Focus ◽

Nano Drug Delivery ◽

Medical Researchers ◽

History Of ◽

Overall Performance ◽

Enhanced Stability

Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

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