scholarly journals Polycystic Ovary Syndrome in Teenage and Young Women

2019 ◽  
Vol 37 (2) ◽  
pp. 78-82
Author(s):  
Kamrun Nahar
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Reproductive Medicine ◽  
Polycystic Ovary ◽  
Human Reproduction ◽  
Ovulatory Cycle ◽  
Ovarian Dysfunction ◽  
Ovary Syndrome ◽  
Metabolic Derangement ◽  
American Society

Polycystic ovary syndrome (PCOS) is an inherent ovarian dysfunction. It is a common health problem that can affect teen girls and young women. PCOS is characterized by hyperandrogenism, irregular ovulatory cycle and metabolic derangement , including glucose intolerance and hyperinsulinaemia. Hyperandrogenism is a clinical hallmark of PCOS. Hypersecretion of androgen by the stromal theca cell of polycystic ovary is cardinal clinical manifestation. Though the exact cause of PCOS is not known , the syndrome can result from disturbance in the hypothalamo pituitary ovarian axis and hyperinsulinaemia. Several definitions have been produced to describe the disease. European society of human reproduction and embryology and the American society for reproductive medicine in 2004 define PCOS as manifestation of two of the following three J Bangladesh Coll Phys Surg 2019; 37(2): 78-82

scholarly journals Polycystic Ovary Syndrome and its Relationship with Infertility and its Management

2020 ◽  
Vol 39 (1) ◽  
pp. 53-58
Author(s):  
Zakia Jahan ◽  
Kirsten Elyse Wing
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Positive Influence ◽  
Ovulatory Cycle ◽  
Ovary Syndrome ◽  
Metabolic Derangement ◽  
Insulin Metabolism ◽  
Irregular Period ◽  
Hypothalamic Pituitary Axis ◽  
Multiple Treatments

Polycystic ovary syndrome (PCOS) is the most common and treatable endocrine dysfunction in fertile women. The pathophysiology of PCOS involves primary defects in the hypothalamic–pituitary axis, insulin secretion and action, and ovarian function.Studies show 20-40 percent of female first-degree relatives of women with PCOS also have the syndrome.Genetic studies have identified a link between PCOS and disordered insulin metabolism and hyperinsulinemia.PCOS is characterized by hyperandrogenism, irregular ovulatory cycle and metabolic derangement, including glucose intolerance and hyperinsulinemia. Hyperandrogenism is a clinical hallmark of PCOS.In women with PCOS, Ovulation problems are usually the primary cause of infertility. PCOS is the most common cause of anovulatory infertility; ∼ 90–95% of women seeking treatment for infertility have PCOS. PCOS may cause higher risk for infertility, type 2 diabetes, high blood pressure, and endometrial cancer. The most common symptoms are irregular period, weight gain, acne, and excessive facial and body hair. PCOS has no cure but there are multiple treatments that can reduce symptoms. Life style modification includingdiet and exercise, have shown a positive influence on women with PCOS. J Bangladesh Coll Phys Surg 2021; 39(1): 53-58

scholarly journals Current aspects of polycystic ovary syndrome I: definition, pathophysiology, clinical manifestations, diagnosis and complications

2018 ◽  
Vol 91 (1) ◽  
pp. 5-18
Author(s):  
Kun Imre Zoltán ◽  
Kun Ildikó ◽  
Kolcsár Melinda
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Clinical Manifestations ◽  
Human Reproduction ◽  
Ovary Syndrome ◽  
Adrenal Steroidogenesis ◽  
American Society ◽  
Genetically Determined

Abstract Polycystic ovary syndrome (PCOS) is the most frequent endocrine disease among women with childbearing potential, the best-known cause of hirsutism, with a hypothesized prevalence of 8-22%. The first part of the paper discusses the conceptional evolution of the syndrome, from its description in 1935 by Stein and Leventhal till today. It describes the changes in the criteria systems, emphasizing that the Rotterdam criteria, proposed in 2003 by the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine, are still valid today. This system basically differs from earlier (1990) NIH-criteria in one aspect: it introduced two newer phenotypes, one without hyperandrogenism and the other with ovulatory cycles, so it distinguishes 4 phenotypes. The etiology and pathogenesis of PCOS is heterogeneous, multifactorial, poorly understood. We present the 3 leading hypotheses (1 - hypothalamo-hypophyseal disturbances, 2 – primary enzyme disorders in ovarian, or ovarian/adrenal steroidogenesis, resulting primarily in hyperactivity of 17alpha-hydroxylase/17,20-lyase, 3 – insulin resistance-hyperinsulinism and other metabolic dysfunctions). We emphasize the role of genetically determined hyperandrogenism, that of insulin resistance-hyperinsulinism and the importance of reinforcing each other. Subsequently, the aggravating aspects of the frequently associated metabolic syndrome are discussed, and then the effects of the mentioned pathological processes on the endocrine and other organ structures participating in the regulation of sexual functions. We stress the hypothetical role of perinatal and pubertal androgen exposition in the pathogenesis of PCOS. The mechanisms of anovulation and those of the endometrial lesions are discussed, too. The clinical manifestations, the paraclinical and laboratory examinations, the positive and differential diagnosis and the complications are also presented. We intend to deal with the therapeutic aspects of PCOS in an upcoming paper.

scholarly journals Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Zora Lazúrová ◽  
Jana Figurová ◽  
Beáta Hubková ◽  
Jana Mašlanková ◽  
Ivica Lazúrová
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Bisphenol A ◽  
Steroid Hormones ◽  
Polycystic Ovary ◽  
Suppressive Effect ◽  
Human Reproduction ◽  
Control Group ◽  
Ovary Syndrome ◽  
Ovarian Steroidogenesis ◽  
The Relationship

Abstract Objectives There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear. Aim of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Second aim was to assess the relationship of U-BPA to ovarian steroidogenesis in the group with PCOS. Methods Eighty six Caucasian women (age 28.5 ± 5.1 years) diagnosed with PCOS and 32 controls of age 24.9 ± 4.4 years were included in the study. Fasting blood samples were analyzed for biochemical parameters and steroid hormones. U-BPA was measured in the morning urine sample using high pressure liquid chromatography. Results PCOS women had significantly higher U-BPA as compared with control group (p=0.0001). Those with high levels of U-BPA (U-BPA ≥2.14 ug/g creatinine) demonstrated higher serum insulin (p=0.029) and HOMA IR (p=0.037), lower serum estrone (p=0.05), estradiol (p=0.0126), FSH (p=0.0056), and FAI (p=0.0088), as compared with low-BPA group (U- BPA <2.14 ug/g creatinine). In PCOS women, U-BPA positively correlated with age (p=0.0026; R2=0.17), negatively with estradiol (p=0.0001, R2=0.5), testosterone (p=0.0078, R2=0.15), free-testosterone (p=0.0094, R2=0.12) and FAI (p=0.0003, R2=0.32), respectively. Conclusions PCOS women have significantly higher U-BPA concentrations than healthy controls. U-BPA positively correlates with age and negatively with ovarian steroid hormones suggesting a possible suppressive effect of bisphenol A on ovarian steroidogenesis.

scholarly journals Problems and Complications During the Treatment of Infertility in Women with Polycystic Ovary Syndrome

2016 ◽  
Vol 22 (2) ◽  
Author(s):  
Müberra Namlı Kalem ◽  
Ziya Kalem ◽  
Timur Gürgan
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Reproductive Medicine ◽  
Chromosomal Abnormalities ◽  
Polycystic Ovary ◽  
Wide Spectrum ◽  
Treatment Protocol ◽  
Success Rates ◽  
Ovary Syndrome ◽  
Detailed Evaluation ◽  
Selection Of

<p>Polycystic ovary syndrome (PCOS) is the most frequent endocrine disorder existing in women in their reproductive years and it is one of the most evaluated and discussed subjects of reproductive medicine with regard to its diagnosis and treatment.<br />Patients with PCOS constitute the most difficult population in the management of infertility. The factors that increase the success rates in the treatment of PCOS infertility are: pretreatment changes in life style, dietetic and psychological support, a detailed evaluation of the couple and the appropriate selection of the treatment protocol, a wide-spectrum approach to maintaining ovarian and endometrial synchronization in the management of the cycle, and well-developed laboratory conditions to support embryonic quality. However, even if these conditions are provided, OHSS, cancellations of the cycle, poor oocyte, and embryo qualities, unsuccessful fertilization and implantation, chromosomal abnormalities and early losses may still be experienced.</p>

Impaired cardiopulmonary parameters in young women with polycystic ovary syndrome

2006 ◽  
Vol 0 (0) ◽  
pp. 061020035253002-??? ◽  
Author(s):  
Francesco Orio ◽  
Stefano Palomba ◽  
Francesco Giallauria ◽  
Annamaria Colao ◽  
Carlo Vigorito
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Heart Rate Variability in Young Women with Polycystic Ovary Syndrome

2006 ◽  
Vol 11 (4) ◽  
pp. 306-312 ◽  
Author(s):  
Aylin Yildirir ◽  
Funda Aybar ◽  
Giray Kabakci ◽  
Hakan Yarali ◽  
Ali Oto
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Ovary Syndrome
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