scholarly journals Comparison Between Preoperative Image Guided Biopsy and Open Biopsy in Clinically Labeled “Unresectable Carcinoma Pancreas”

2013 ◽  
Vol 23 (2) ◽  
pp. 53-57
Author(s):  
Md Abdullah Al Farooq ◽  
Md Akbar Husain Bhuiyan ◽  
Tania Tajreen ◽  
Mohammad Ali
Keyword(s):  
Cell Carcinoma ◽  
Duct Cell ◽  
Needle Aspiration ◽  
Computed Tomography Scan ◽  
Open Biopsy ◽  
Fine Needle ◽  
Image Guided ◽  
Preoperative Image ◽  
Carcinoma Pancreas ◽  
Tomography Scan

Although clinical findings along with modern laboratory investigations and imaging can help to diagnose pancreatic cancer and label them respectable or unrespectable, tissue diagnosis is essential to confirm the diagnosis and proper management. This retrospective review was done form July 2004 to June 2006 in BIRDEM hospital, Dhaka, Bangladesh, in patient with clinically labeled 'unresectable carcinoma pancreas' to evaluate the preoperative and postoperative biopsy pattern with their histopathological diagnosis. Forty (40) patients were clinically labeled as ‘unresectable carcinoma pancreas'. Preoperative image guided biopsy was taken in 25 patients. Methods of preoperative tissue diagnosis with their histopathology reports were noted. In forty (40) patients it was planned to take open biopsy along with other palliative surgical procedures. In 38 patients tumours found unresectable and biopsy were taken from the lesion, involved organ or lymph node. In 2 patients curative resection were done and whole specimens were sent for histopathology. Histopathology report of post surgical specimen was compared with preoperative histopathology report. Preoperative biopsies were done by ERCP in 12 patients. Ten (10) image (ultrasonography, computed tomography scan) assisted fine needle aspiration biopsy were taken from the pancreatic lesion. Preoperative imaging failed to detect any pancreatic mass in the rest 3 patients but showed suspected liver metastasis. Image (computed tomography scan) assisted 03 fine needle aspiration biopsies were taken from 3 hepatic metastasis. Histopathological report showed pancreatic duct cell carcinoma in 19 (76%) patients, 1(4%) patients had chronic pancreatitis. Biopsy report was not conclusive in 2 (8%) patients. All 3 biopsies from liver focus were metastatic pancreatic cancer (12%). Histopathology report of laparotomy samples revealed that 35 patients (87.5%) had pancreatic duct cell carcinoma. Out of the rest 5 patients 2 patients (5%) were chronic pancreatitis, non Hodgkin's lymphoma 01 patients (2.5%), tuberculosis 01patients (2.5%) and metastatic renal cell carcinoma 01 patient (2.5%). Open biopsy has a greater diagnostic accuracy than preoperative biopsy in diagnosing unrespectable pancreatic carcinoma and to exclude other pancreatic mass lesions labeled clinically as ‘unrespectable carcinoma pancreas'. Open biopsy is recommended in clinically labeled 'unrespectable carcinoma pancreas'. JCMCTA 2012 ; 23 (2): 53-57

Deep Lobe Parotid Tumors: A Systematic Review and Meta-analysis

2021 ◽  
pp. 019459982110092
Author(s):  
Margaret H. Aasen ◽  
Michael J. Hutz ◽  
Brian T. Yuhan ◽  
Christopher J. Britt
Keyword(s):  
Facial Nerve ◽  
Imaging Modality ◽  
Meta Analysis ◽  
Needle Aspiration ◽  
Computed Tomography Scan ◽  
Fine Needle ◽  
Deep Lobe ◽  
Parotid Tumors ◽  
Superficial Lobe ◽  
Tomography Scan

Objective We performed a systematic review and meta-analysis of deep lobe parotid tumors to evaluate their unique characteristics. Data Sources PubMed/Medline, Embase, Web of Sciences, and Cochrane Library databases were queried for relevant literature. Review Methods Studies were individually assessed by 2 independent reviewers. Risk of bias was assessed with the Cochrane bias tool, GRADE criteria, and MINORS criteria. Results were reported according to the PRISMA guidelines. Statistical analysis was performed by comparing rates of malignancy between deep and superficial lobe tumors. Results In total, 8 studies including 379 deep lobe parotid tumors met inclusion criteria. Mean age at diagnosis was 44.9 years. Computed tomography scan was the most common imaging modality. Preoperative diagnostic fine-needle aspiration was utilized in 39.4% of patients and demonstrated high sensitivity for malignant disease. The most common approach was subtotal parotidectomy with facial nerve preservation (58.9%). The rate of malignancy was 26.6%, which was significantly higher than that of the superficial lobe tumors in this study (risk ratio, 1.25; 95% CI, 1.01-1.56). The rate of temporary postoperative facial nerve weakness between deep and superficial lobe tumors was 32.5% and 11.7%, respectively. Conclusion Deep lobe parotid tumors had a 26.6% rate of malignancy. On meta-analysis, deep lobe tumors appeared to have higher rates of malignancy than superficial lobe tumors. Surgical excision of deep lobe tumors showed increased rates of temporary facial nerve paresis as compared with superficial lobe tumors. Computed tomography scan was the most common imaging modality. There were limited data regarding the utility of fine-needle aspiration.

Diffuse Hyperplastic Perilobar Nephroblastomatosis

2009 ◽  
Vol 12 (3) ◽  
pp. 237-238 ◽  
Author(s):  
Jimena Vicens ◽  
Alejandro Iotti ◽  
Mercedes Garcia Lombardi ◽  
Roberto Iotti ◽  
Maria Teresa Garcia de Davila
Keyword(s):  
Computed Tomography ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Left Kidney ◽  
Needle Aspiration ◽  
Computed Tomography Scan ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Tomography Scan

Nephroblastomatosis is a rare preneoplastic lesion defined as the presence of diffuse or multifocal nephrogenic rests. They are divided into 4 categories: perilobar, intralobar, combined, and universal. The aim of this report is to describe a case of diffuse hyperplastic perilobar nephroblastomatosis. A 1-year-old boy presented with an abdominal mass on the left side. Computed tomography scan showed a homogeneous, isointense enlarged left kidney. A fine needle aspiration cytology was reported as Wilms tumor. After chemotherapy, the left kidney was excised. Nephrectomy specimen presented a thick cortical rim of hyperplastic nephrogenic tissue, well delineated from preserved renal parenchyma without pseudocapsule. Nephroblastomatosis is a rare condition affecting renal parenchyma. Diagnosis is based on imaging studies, such as ultrasound, computed tomography scan, and magnetic resonance imaging. Fine needle aspiration cytology is of limited value. Therapeutic management is controversial. Chemotherapy is used preoperatively, and surgical excision may be an alternative for refractory cases.

Fine Needle Aspiration of Chromophobe Renal Cell Carcinoma

2007 ◽  
Vol 51 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Javier Salamanca ◽  
Nuria Alberti ◽  
Fernando López-Ríos ◽  
Andrés Perez-Barrios ◽  
Miguel Angel Martínez-González ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Fine Needle Aspiration ◽  
Renal Cell ◽  
Needle Aspiration ◽  
Chromophobe Renal Cell Carcinoma ◽  
Fine Needle

scholarly journals Efficacy of rapid on-site cytological evaluation (ROSE) by a pulmonologist in determining specimen adequacy and diagnostic accuracy in interventional diagnosis of lung lesions

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052098268
Author(s):  
Mingli Yuan ◽  
Yafei Wang ◽  
Wen Yin ◽  
Yang Xiao ◽  
Manman Hu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Diagnostic Accuracy ◽  
Cell Carcinoma ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
Small Cell ◽  
Diagnostic Efficacy ◽  
Lung Lesions ◽  
Fine Needle ◽  
Cytological Evaluation

Objective To evaluate the efficacy of rapid on-site cytological evaluation (ROSE) in determining specimen adequacy and diagnostic accuracy in the interventional diagnosis of lung lesions. Methods This retrospective study included 127 consecutive cases of lung lesions, which were sampled by bronchoscopy or transthoracic fine needle aspiration, and diagnosed on ROSE followed by histopathology. ROSE was performed by a trained pulmonologist and the diagnosis of ROSE was compared with the final diagnosis. Results The sensitivity of ROSE in determining adequacy of specimens was 97.5% and specificity in determining inadequacy was 85.7%. The diagnostic efficacy of ROSE for assessing malignancy (sensitivity of 94.5% and specificity of 100%) and non-malignancy (sensitivity of 97.8% and specificity of 100%) was excellent. The sensitivity of ROSE for diagnosing small cell carcinoma (100%) was highest, followed by adenocarcinoma (89.2%) and squamous cell carcinoma (75.0%). Performance of ROSE by a trained pulmonologist also determined tuberculosis with a high diagnostic sensitivity (83.3%) and specificity (100%). Conclusions A trained pulmonologist can reliably carry out ROSE to ensure the adequacy of the sample, distinguish between malignancy and non-malignancy, and make a preliminary diagnosis in a large number of cases.

A Pilot Study Evaluating Fine-Needle Aspiration Cytology of Clear-Cell Renal Cell Carcinoma: Comparison of Ancillary Immunocytochemistry and Cytomorphological Characteristics of SurePath™ Liquid-Based Preparations with Conventional Smears

2015 ◽  
Vol 59 (3) ◽  
pp. 239-247 ◽  
Author(s):  
Chung Hun Lee ◽  
Soo Young Chung ◽  
Kyung Chul Moon ◽  
In Ae Park ◽  
Yul Ri Chung ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Fine Needle Aspiration ◽  
Renal Cell ◽  
Fine Needle Aspiration Cytology ◽  
Clear Cell ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Objective: Fine-needle aspiration cytology (FNAC) based on a liquid-based preparation is a safe and valuable diagnostic tool. However, due to unfamiliarity with this method and the considerably altered morphology that is associated with it, diagnosing renal cell carcinoma (RCC) from this type of preparation remains a challenge for cytopathologists. The aim of this study was to evaluate the cytomorphological characteristics of SurePath™ (SP)-based preparations compared with conventional smear (CS), and also the role of SP-based FNAC in the diagnosis of clear-cell RCC (CRCC), the most common primary renal malignancy. Study Design: Ex vivo FNAC of both tumors and normal renal parenchyma was prepared from 73 cases. Comparative cytomorphological analysis between liquid-based cytology (LBC) and CS as well as Fuhrman nuclear grading (FNG) was carried out. Immunocytochemistry was performed from normal and CRCC cytology specimens. Results: Normal renal cytology (NRC) showed no significant morphological differences between LBC and CS. For CRCC, LBC showed small, fragmented cell clusters, a 3-dimensional configuration, distinct cytoplasmic vacuoles, and irregular nuclear contours when compared with CS. FNG was overgraded with LBC compared to with CS. AMACR was the most valuable immunocytochemical marker for distinguishing CRCC from NRC. Conclusion: Once cytopathologists become familiar with the altered cytomorphological features of CRCC, FNAC, along with immunocytochemistry, may prove helpful for diagnosis.

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