An Uncommon Presentation of Myasthenia Gravis with Thymoma - A Case Report and Review of Literature

Myasthenia Gravis (MG) is a rare disease of neuromuscular junction which typically presents with fatigable weakness of cranial and limb muscles. But patient may present with vague symptoms which may mislead physicians to an incorrect diagnosis. We are reporting a 45 year old cobbler presented with the complaints of lack of energy, aching pain in shoulder, back, upper arm and difficulty in swallowing of both solid and liquid food without any diurnal variation for two and half years. He was ultimately diagnosed as a case of MG and thymectomy revealed thymoma. DOI: http://dx.doi.org/10.3329/jom.v13i1.10087 JOM 2012; 13(1): 109-114

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Post-thymectomy myasthenia gravis: a case report and systematic review of literature

BMJ Case Reports ◽

10.1136/bcr-2021-246005 ◽

2021 ◽

Vol 14 (12) ◽

pp. e246005

Author(s):

Louise Gurowich ◽

Gabriel Yiin ◽

Adam Maxwell ◽

Alexandra Rice

Keyword(s):

Systematic Review ◽

Case Report ◽

Myasthenia Gravis ◽

Early Onset ◽

Late Onset ◽

High Morbidity ◽

Review Of Literature ◽

Prompt Treatment ◽

Autoimmune Condition ◽

Anti Acetylcholine

Myasthenia gravis (MG) is an autoimmune condition affecting the neuromuscular junction characterised by weakness and fatiguability, carrying a high morbidity if treatment is delayed. A clear association with thymoma has led to management with thymectomy as a common practice, but MG presenting post-thymectomy has rarely been reported. We present a case of an 82- year-old woman developing fatigue, ptosis and dysarthria 3 months after thymectomy. After a clinical diagnosis of MG was made, she responded well to prompt treatment with prednisolone and pyridostigmine. Her anti-acetylcholine receptor antibody (anti-AChR) subsequently came back positive. Our systematic review reveals that post-thymectomy MG can be categorised as early-onset or late-onset form with differing aetiology, and demonstrated correlation between preoperative anti-AChR titres and post-thymectomy MG. The postulated mechanisms for post-thymectomy MG centre around long-lasting peripheral autoantibodies. Clinicians should actively look for MG symptoms in thymoma patients and measure anti-AChR preoperatively to aid prognostication.

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Failure of reversion of neuromuscular block with sugammadex in patient with myasthenia gravis: case report and brief review of literature

BMC Anesthesiology ◽

10.1186/s12871-019-0829-0 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 5

Author(s):

Hermann dos Santos Fernandes ◽

Jorge Luiz Saraiva Ximenes ◽

Daniel Ibanhes Nunes ◽

Hazem Adel Ashmawi ◽

Joaquim Edson Vieira

Keyword(s):

Case Report ◽

Myasthenia Gravis ◽

Neuromuscular Block ◽

Review Of Literature

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Seeking spark- ocular myasthenia gravis in a juvenile – an Indian case report

Tropical Journal of Ophthalmology and Otolaryngology ◽

10.17511/jooo.2020.i07.04 ◽

2020 ◽

Vol 5 (7) ◽

pp. 190-193

Author(s):

Dr. Usha BR. ◽

◽

Dr. Nandhini K ◽

Dr. Chaitra MC ◽

◽

...

Keyword(s):

Case Report ◽

Neuromuscular Junction ◽

Myasthenia Gravis ◽

Autoimmune Disorder ◽

Bilateral Ptosis ◽

Ocular Myasthenia ◽

Ocular Myasthenia Gravis ◽

History Of ◽

High Index Of Suspicion

Myasthenia gravis (MG) is a rare autoimmune disorder affecting neuromuscular junction by muscleweakness. Myasthenia gravis can be generalized or localized as ocular myasthenia gravis. Casepresentation: We report an 8-year-old boy who presented with 10 days history of drooping of botheyelids and 8 days history of diplopia. Examination revealed bilateral ptosis. A diagnosis of JuvenileOcular Myasthenia gravis was made when symptoms improved with intramuscular Edrophoniumadministration. He was commenced on oral Neostigmine at a dose of 2mg/Kg/ day,4 hourly individed doses and is on regular follow up and had a good response. Conclusion: Ocular Myastheniagravis (OMG) is a rare disease in itself. A high index of suspicion is required in a juvenile as it iseven rarer.

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Unusual site and uncommon presentation of epidermoid cyst: a rare case report and review of literature

BMJ Case Reports ◽

10.1136/bcr-2012-007907 ◽

2013 ◽

Vol 2013 (jan08 1) ◽

pp. bcr2012007907-bcr2012007907 ◽

Cited By ~ 2

Author(s):

M. R. Sahoo ◽

M. S. Gowda ◽

S. S. Behera

Keyword(s):

Case Report ◽

Epidermoid Cyst ◽

Rare Case ◽

Review Of Literature ◽

Unusual Site ◽

Uncommon Presentation ◽

Rare Case Report

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Langerhans cell histiocytosis of the extra-hepatic bile duct a case report of an uncommon presentation of a rare disease

10.26226/morressier.5b4709886f4cb300109517dc ◽

2018 ◽

Author(s):

Nuno Jorge Lamas

Keyword(s):

Case Report ◽

Bile Duct ◽

Rare Disease ◽

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Hepatic Bile ◽

Hepatic Bile Duct ◽

Uncommon Presentation

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Vertebrobasilar dolichoectasia presenting as symptomatic obstructive hydrocephalus: A case report with review of literature

Indian Journal of Neurosurgery ◽

10.4103/2277-9167.102296 ◽

2012 ◽

Vol 01 (02) ◽

pp. 165-168 ◽

Cited By ~ 2

Author(s):

Roopa Seshadri ◽

Nishant Sadashiva ◽

Dhaval Shukla ◽

Jitender Saini ◽

Paritosh Pandey

Keyword(s):

Case Report ◽

Ventriculoperitoneal Shunt ◽

Cranial Nerve ◽

Obstructive Hydrocephalus ◽

Mass Effect ◽

Review Of Literature ◽

Uncommon Presentation ◽

Vertebrobasilar Dolichoectasia ◽

Cranial Nerve Palsies ◽

Basilar Arteries

Abstract Vertebrobasilar dolichoectasia (VBD) is a common, but usually asymptomatic condition characterized by marked elongation, dilatation, and tortousity of the vertebral and basilar arteries. VBD can sometimes present with symptoms related to mass effect like cranial nerve palsies, or with ischemia or hemorrhage. Hydrocephalus is an extremely uncommon presentation of VBD. We describe here a patient with VBD who presented with symptomatic hydrocephalus due to third ventricular obstruction, which was relieved by ventriculoperitoneal shunt.

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