scholarly journals Effects of Combination of Antidiabetic Agent and Statin on Alloxan-induced Diabetes with Cardiovascular Diseases in Rats

2012 ◽  
Vol 4 (3) ◽  
pp. 709-720 ◽  
Author(s):  
M. S. Islam ◽  
A. H. M. K. Alam ◽  
M. A. A. Rahman ◽  
Y. Ali ◽  
Al Mamun ◽  
...  
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Diabetic Rats ◽  
Free Radical Scavenging ◽  
Scavenging Activity ◽  
Antidiabetic Agent ◽  
Pathological Changes ◽  
Short Term ◽  
Combination Drugs

The present study was designed to investigate the effects of combination drugs (metformin and atorvastatin) on long-term alloxan-induced diabetes with CVD in rats. In short-term alloxan-induced diabetic rats, metformin reduced significant amount of glucose in blood, but it had no significant effect on lipid profile. Atorvastatin significantly reduced TC, TG and LDL-C, whereas it increased significant amount of HDL-C. However, pathological changes of heart were not observed after short-term induction of alloxan in rats. In long-term induction of diabetes by alloxan, LV hypertrophy was observed and cardimyocyte size in rats was increased. Atorvastatin alone and in combination with metformin significantly reduced the LV hypertrophy, cardiomyocyte size, TC, TG and LDL-C level. They increased significant amount of HDL-C level and showed significant DPPH free radical scavenging activity. Present findings may suggest that treatment with combination therapy is more effective than mono-therapy for preventing diabetes with CVD in rats.© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v4i3.9974 J. Sci. Res. 4 (3), 709-720 (2012)

scholarly journals IN VITRO FREE RADICAL SCAVENGING ACTIVITY AND IN VIVO ANTICATARACT POTENTIAL OF HEMIDESMUS INDICUS ROOTS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

2017 ◽  
Vol 10 (12) ◽  
pp. 129
Author(s):  
Prabhakar Tirumani ◽  
Rajashekhar Av
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Ethyl Acetate Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Diabetic Rats ◽  
Free Radical Scavenging ◽  
Plant Roots ◽  
Scavenging Activity ◽  
Hemidesmus Indicus

Objective: Hemidesmus indicus R. Br. (HI) (Indian sarsaparilla) is traditionally used in Indian medicine for human therapy. The present study was aimed to evaluate the antioxidant activity of HI root extracts, and its effects on delaying (or) management of cataract progression in streptozoticin (STZ) induced diabetic rats.Methods: The plant roots were extracted in different solvents, estimated total phenolic content, total flavonoid content and conducted free radical scavenging potential through 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2 azinobis (3-ethyl benzothiazoline-6-sulphonic acid diammonium salt (ABTS) NO, OH and reducing power assays. Further, the protective effect was evaluated in STZ induced diabetic rats through administered of ethyl acetate extract of HI (200 and 400 mg/kg body weight) orally for 8 weeks to study its effect on oxidative stress and diabetic cataract progression.Results: In primary results demonstrated that the ethyl acetate extract has been showed considerable free radical scavenging activity and significantly gain body weight, gradual decreasing blood glucose levels and delay cataract progression has been observed in HI treated rats. Furthermore, we observed significantly decreased oxidative stress markers, and restoration of the antioxidant system in HI treated rats. Lens sections from experimental animal again evidenced to conform the ameliorative effect of HI on diabetic cataract.Conclusion: This obtained result’s confirmed that the protective effect of HI is attributed to the antioxidant activities of plant roots and its active principles.

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