scholarly journals A comparison between palonosetron and ondansetron in prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

Mediscope ◽  
2015 ◽  
Vol 2 (2) ◽  
pp. 33-38
Author(s):  
A Gafur ◽  
L Noor ◽  
A Motin ◽  
M Alam ◽  
M Karim
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Side Effects ◽  
Postoperative Period ◽  
Postoperative Nausea ◽  
Adverse Outcome ◽  
Postoperative Nausea And Vomiting ◽  
Nausea And Vomiting ◽  
Double Blind Study ◽  
Double Blind ◽  
Complete Control

Postoperative nausea and vomiting (PONV) are common complications after anesthesia and surgery and is associated with adverse outcome. This study was designed to compare the effects of palonosetron and ondansetron in preventing PONV in patients with laparoscopic cholecystectomy. This prospective double-blind study included 60 female patients randomly assigned to the palonosetron group (n = 30) or the ondansetron group (n = 30). Palonosetron 0.075 mg was injected intravenously as a bolus in the palonosetron group. Ondansetron 8 mg was injected intravenously as a bolus in the ondansetron group. The incidences of nausea and vomiting and side effects was recorded after 30 min, 60 min, 2 hrs, 8hrs, 24 hrs postoperatively. The incidence of nausea and vomiting was maximal during immediate postoperative period particularly initial 4 hrs of postoperative period. The complete control of postoperative nausea and vomiting was seen in 30% patients of ondansetron group in first 12 hrs of postoperative period and 90% in palonosetron group. Safety profile was more with palonosetron. The effects of palonosetron and ondansetron in preventing PONV were compared in patients undergoing laparoscopic cholecystectomy and it was found that palonosetron was better in preventing postoperative nausea and vomiting.Mediscope Vol. 2, No. 2: July 2015, Pages 33-38

A RANDOMIZED, DOUBLE-BLIND STUDY OF PALONOSETRON COMPARED WITH ONDANSETRON IN PREVENTING POSTOPERATIVE NAUSEA AND VOMITING AFTER MODIFIED RADICAL MASTECTOMY SURGERY.

2021 ◽  
pp. 72-74
Author(s):  
Anusha K ◽  
Sherin bright
Keyword(s):  
Side Effects ◽  
Postoperative Nausea ◽  
Radical Mastectomy ◽  
Postoperative Nausea And Vomiting ◽  
Complete Response ◽  
Nausea And Vomiting ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Post Operative Nausea

BACKGROUND : Palonosetron is a new potent 5-hydroxytryptamine 3 antagonist. Although used for chemo induced emesis, data is lacking for PONV. The high incidence of nausea and vomiting after breast surgery is well documented. This study compared the effects of i.v.ondansetron and palonosetron administered at the time of induction for preventing postoperative nausea and vomiting (PONV) in these high-risk patients . The aim was to compare Onda METHODS : nsetron 8 mg and Palonosetron 0.075mg administered intravenously for prevention of post operative nausea and vomiting in patients undergoing modied radical mastectomy 24 hours postoperatively, by a randomised , controlled, double blind study. 70 female non smoking patients scheduled for elective modied radical mastectomy were, allocated randomly into 2 groups . Patients received either Palonosetron 0.075mg (GROUP P ) or ondansetron 8mg ( GROUP O ) intravenously, immediately before induction of general anaesthesia. The occurence of nausea, vomiting, retching, need for rescue antiemetics and side effects were monitored for a period of 24 hours after surgery. The compete response rate and overall PONV for 0 - 24 hours were calculated. The demographic prole of the patients were comparable. The RESULTS : incidence of a complete response (no PONV, no rescue antiemetics ) during 0 - 24 hours in post operative period was signicantly high in GROUP P ( 85.7% vs 62.9%, p=0.02) than GROUP O. The incidence of nausea was signicantly low in GROUP P ( 14.3% vs 37.1%). There was no statistically signicant difference between the 2 groups in vomiting, retching, side effects and need for rescue antiemetics. Thus overall PONV was low in GROUP P (14.3% vs 37.1% p = 0.02 statistically signicant.) We conclude that Palonosetron 0.075mg was more effective for preventing PONV in patients undergoing modied radical mastectomy surgery

scholarly journals Evaluating the Effect of Intraoperative Dextrose 10% Administration on Reducing Postoperative Nausea and Vomiting after Laparoscopic Surgery

2019 ◽  
Vol 13 (1) ◽  
pp. 78-85
Author(s):  
Ashraf Nabil Saleh ◽  
Dalia Fahmy Emam ◽  
Mohamed Mohamed Kamal
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Postoperative Nausea ◽  
Postoperative Nausea And Vomiting ◽  
Study Groups ◽  
Primary Objective ◽  
Nausea And Vomiting ◽  
Controlled Study ◽  
Double Blind ◽  
Female Patients ◽  
Medication Consumption

Background: Although PONV is usually self-limiting or is treated without sequelae, the incidence of PONV could be as high as 70% to 80% in high-risk populations such as female sex, obese patients, age younger than 40 years, nonsmoker patients, history of PONV or motion sickness. Objectives: The study aimed to investigate whether dextrose 10% decreases the incidence of postoperative nausea and vomiting in female patients undergoing laparoscopic cholecystectomy Materials and Methods: This prospective, double-blind randomized placebo-controlled study comprised 130 ASA physical status I and II nonsmoker female patients, 20-40 years of age, scheduled for laparoscopic cholecystectomy at Ain Sham University – Assembled operating theater from August 2018 to October 2018. Patients were arbitrarily divided into two study groups of 65 patients each. Group LR received lactated Ringer’s solution and group D received 10% dextrose. The primary objective of this study was to compare the incidence of PONV in the study treatment groups. The secondary outcomes included measurement of antiemetic medication consumption as well as blood glucose changes between groups. Results: 50 from a total of 65 participants (76.9%) in Lactated Ringer (LR) group experienced nausea. On the other hand, 30 participants only (46.2%) in dextrose (D) group were nauseated. This dissimilarity was statistically highly significant (P= 0.0003). Conclusion: In this study, dextrose 10% administration resulted in improved postoperative emesis management as explained by the lower incidence of nausea and rescue antiemetic consumption.

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