scholarly journals A case of adrenocortical oncocytic carcinoma arising in ectopic adrenal tissue: a multidisciplinary diagnostic challenge

2020 ◽  
Vol 14 ◽  
Author(s):  
Nikita Wadhwani ◽  
Daniel Mais ◽  
Dharam Kaushik ◽  
Mio Kitano
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Lea F. Surrey ◽  
Ashesh A. Thaker ◽  
Paul J. Zhang ◽  
Giorgos Karakousis ◽  
Michael D. Feldman

Functioning adrenal adenomas are well-described entities that can rarely occur outside the adrenal gland in the ectopic adrenal tissue. Similarly, myelolipoma is an another benign lesion of the adrenal tissue which can rarely occur outside the adrenal gland. We report the first case of a testosterone producing an extra-adrenal adrenocortical oncocytoma accompanied by a myelolipoma. The patient presented with virilization and elevated androgen levels. Imaging revealed a retroperitoneal mass, which histologically consisted of oncocytes and intermingled myelolipoma. Postoperative androgen levels decreased to normal. The tumor cells were strongly positive for inhibin and Melan-A, supporting the adrenal origin. This case demonstrates a diagnostic challenge in which correlation with histology, immunohistochemistry, and serum endocrine studies led to the final diagnosis.


2018 ◽  
Vol 26 (7) ◽  
pp. 588-592 ◽  
Author(s):  
Mustafa Q. Yousif ◽  
Ziyan T. Salih ◽  
Barry R. DeYoung ◽  
Shadi A. Qasem

Background. Adrenal rest (AR) is the presence of ectopic adrenal cortical tissue, often identified incidentally during autopsy (20% of postmortem examination). In the kidney, AR can be found in 6% of the general population. Ectopic adrenal tissue is of no functional significance but may in some cases, pose a diagnostic challenge for the pathologist, especially in the context of renal clear cell renal cell carcinoma (RCC) and small needle biopsies. Aim. To investigate the utility of immunohistochemical stains in distinguishing AR from RCC. Methods. Archival cases of AR, in our institution, were reviewed and compared with a cohort of RCC cases using a panel of immunohistochemical stains, including PAX2, PAX8, calretinin, and inhibin. Results. Nine of 10 (90%) cases of AR showed positive staining for inhibin and negative staining for calretinin, PAX2 and PAX8. One AR case was positive for PAX2 and PAX8 in addition to inhibin. All (100%) RCC cases were positive for PAX2 and PAX8, but negative for inhibin and calretinin. Conclusions. A panel of PAX2, PAX8 and inhibin may be useful markers for distinguishing AR from RCC. Calretinin was noncontributory in our study.


2020 ◽  
Vol 14 (3) ◽  
pp. 163-165
Author(s):  
Caleb Miller ◽  
Syed Johar Raza ◽  
Elizabeth Davaro ◽  
Guihau Cao ◽  
Zachary Hamilton

Adrenal-renal fusion with adrenal cortical adenoma is a rare anomaly with only a few cases described in the literature. Imaging-based identification of this anomaly remains a diagnostic challenge, making it difficult to differentiate upper pole renal malignancy from adrenal cortical adenoma. We describe a case of a 62-year-old woman with an upper pole cystic renal mass on imaging, who underwent robotic partial nephrectomy. Intraoperatively the renal mass was found to be an adrenal-renal fusion anomaly, with ectopic adrenal tissue. Adrenal-renal infusion of an adrenal cortical adenoma was confirmed on final pathology. Due to lack of imaging-based diagnosis, this condition should be considered in the differential for upper pole renal masses.


2019 ◽  
Vol 20 (-1) ◽  
pp. 259-259
Author(s):  
Berna Gul ◽  
◽  
Mustafa Karsli ◽  
Sevgi Pekcan ◽  
Tamer Altinok ◽  
...  

2000 ◽  
Vol 147 (11) ◽  
pp. 303-304 ◽  
Author(s):  
S. E. Long ◽  
I. Thomas ◽  
G. R. Pearson

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Asiye Safak Bulut ◽  
Tevfik Uğur Sipahi

Adenomyosis, also known as endometriosis interna, is the presence of endometrial glands and stroma within the myometrium. Its localised form is called adenomyoma and mimics a leiomyoma. Rarely, adenomyomas are located outside the uterus and some of them form uterus-like masses with a thick muscle wall and an endometrium-lined central cavity. They are generally located in the ovary or broad ligament, and, although they are closely related to endometriosis, their pathogenetic mechanisms are different from each other. Müllerian duct fusion defect and subcoelomic mesenchyme transformation theory are two possible pathogenetic mechanisms for this rare entity. Here we report abscessed uterine and extrauterine adenomyomas forming uterus-like masses in the left and right broad ligament and an ectopic adrenal tissue in the left paraovarian region in a 56-year-old woman. Although there is a reported abscessed adenomyosis in the literature, this is the first abscessed extrauterine uterus-like masses with synchronous pelvic pathologies like endometriosis, leiomyomas, adenomyosis, an endometrial polyp, an endocervical polyp, and an ectopic adrenal tissue. This benign lesion gives the impression of leiomyoma, a uterine malformation, or even malignancy preoperatively. Frozen section helps in differential diagnosis.


1979 ◽  
Vol 13 (3) ◽  
pp. 221-224 ◽  
Author(s):  
D. E. Prentice ◽  
W. Jorgeson

Summary The histological appearances of 5 cases are described. The origin, incidence and significance of ectopic adrenals are discussed.


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