Optimization of method for simultaneous multi-element determination of trace elements by Inductively Coupled Plasma-Optical Emission Spectrometry: Chemometric approach

Two objective functions for multi-element optimization in ICP-OES were used and compared using signal-to-background ratios as a figure of merit. Three dimensional response surfaces were generated for a number of elements (Fe, Zn, Cu, Se, Mn, Cr, Ni and Co) to evaluate the performance of both objective functions in locating the optimum compromise instrumental operating conditions in multielement determinations. IEC technique was used for correction of spectral interferences. Validation of the applied method was carried out by determination of linearity (1 to 100 μg/l), accuracy, precision, detection and quantification limit for each element. Detection limit was calculated using SBR-RSD approach. Both objective functions gave the same set of instrumental operating conditions for simultaneous multi-element determination as the best compromise.