scholarly journals Neurochemical Characterization of the TRPV1-Positive Nociceptive Primary Afferents Innervating Skeletal Muscles in the Rats

2008 ◽  
Vol 43 (2) ◽  
pp. 97 ◽  
Author(s):  
Dong Su Shin ◽  
Eun Hyun Kim ◽  
Kwan Young Song ◽  
Hyun Jong Hong ◽  
Min Ho Kong ◽  
...  
Keyword(s):  
Skeletal Muscles ◽  
Primary Afferents

scholarly journals Deletion of small ankyrin 1 (sAnk1) isoforms results in structural and functional alterations in aging skeletal muscle fibers

2015 ◽  
Vol 308 (2) ◽  
pp. C123-C138 ◽  
Author(s):  
E. Giacomello ◽  
M. Quarta ◽  
C. Paolini ◽  
R. Squecco ◽  
P. Fusco ◽  
...  
Keyword(s):  
Structural Damage ◽  
Skeletal Muscles ◽  
Functional Characterization ◽  
Sr Proteins ◽  
Endurance Test ◽  
Tubular Aggregates ◽  
Functional Studies ◽  
Old Mice ◽  
Contractile Performance

Muscle-specific ankyrins 1 (sAnk1) are a group of small ankyrin 1 isoforms, of which sAnk1.5 is the most abundant. sAnk1 are localized in the sarcoplasmic reticulum (SR) membrane from where they interact with obscurin, a myofibrillar protein. This interaction appears to contribute to stabilize the SR close to the myofibrils. Here we report the structural and functional characterization of skeletal muscles from sAnk1 knockout mice (KO). Deletion of sAnk1 did not change the expression and localization of SR proteins in 4- to 6-mo-old sAnk1 KO mice. Structurally, the main modification observed in skeletal muscles of adult sAnk1 KO mice (4–6 mo of age) was the reduction of SR volume at the sarcomere A band level. With increasing age (at 12–15 mo of age) extensor digitorum longus (EDL) skeletal muscles of sAnk1 KO mice develop prematurely large tubular aggregates, whereas diaphragm undergoes significant structural damage. Parallel functional studies revealed specific changes in the contractile performance of muscles from sAnk1 KO mice and a reduced exercise tolerance in an endurance test on treadmill compared with control mice. Moreover, reduced Qγcharge and L-type Ca2+current, which are indexes of affected excitation-contraction coupling, were observed in diaphragm fibers from 12- to 15-mo-old mice, but not in other skeletal muscles from sAnk1 KO mice. Altogether, these findings show that the ablation of sAnk1, by altering the organization of the SR, renders skeletal muscles susceptible to undergo structural and functional alterations more evident with age, and point to an important contribution of sAnk1 to the maintenance of the longitudinal SR architecture.

scholarly journals Chloroquine-Induced Accumulation of Gangliosides and Phospholipids in Skeletal Muscles. Quantitative Determination and Characterization of Stored Lipids

1981 ◽  
Vol 116 (3) ◽  
pp. 565-571 ◽  
Author(s):  
Olle NILSSON ◽  
Pam FREDMAN ◽  
Georg W. KLINGHARDT ◽  
Henri DREYFUS ◽  
Lars SVENNERHOLM
Keyword(s):  
Quantitative Determination ◽  
Skeletal Muscles

G.P.14.09 Functional characterization of skeletal muscles in DM1 mice

2007 ◽  
Vol 17 (9-10) ◽  
pp. 856-857
Author(s):  
A. Ferry ◽  
G. Gourdon ◽  
A. Huguet ◽  
G. Butler-Browne ◽  
D. Furling ◽  
...  
Keyword(s):  
Skeletal Muscles ◽  
Functional Characterization

scholarly journals The wonder exerkines—novel insights: a critical state-of-the-art review

2021 ◽  
Author(s):  
Laura Magliulo ◽  
Danilo Bondi ◽  
Niccolò Pini ◽  
Lorenzo Marramiero ◽  
Ester Sara Di Filippo
Keyword(s):  
Skeletal Muscles ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Transport Mechanisms ◽  
Humoral Factors ◽  
Multiple Organs ◽  
Single Bout ◽  
Type Of Exercise ◽  
Response To Exercise

AbstractSeveral benefits can be acquired through physical exercise. Different classes of biomolecules are responsible for the cross-talk between distant organs. The secretome of skeletal muscles, and more widely the field of organokines, is ever-expanding. “Exerkine” has emerged as the umbrella term covering any humoral factors secreted into circulation by tissues in response to exercise. This review aims at describing the most interesting exerkines discovered in the last 3 years, which are paving the way for both physiological novel insights and potential medical strategies. The five exerkines identified all play a significant role in the healthy effect of exercise. Specifically: miR-1192, released by muscles and myocardium into circulation, by modulating cardioprotective effect in trained mice; miR-342-5p, located into exosomes from vascular endothelial cells, also a cardioprotective miRNA in trained young humans; apelin, released by muscles into circulation, involved in anti-inflammatory pathways and muscle regenerative capacity in rats; GDF-15, released into circulation from yet unknown source, whose effects can be observed on multiple organs in young men after a single bout of exercise; oxytocin, released by myoblasts and myotubes, with autocrine and paracrine functions in myotubes. The systemic transport by vesicles and the crosstalk between distant organs deserve a deep investigation. Sources, targets, transport mechanisms, biological roles, population samples, frequency, intensity, time and type of exercise should be considered for the characterization of existing and novel exerkines. The “exercise is medicine” framework should include exerkines in favor of novel insights for public health.

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