Background: Laparoscopy involves insufflation of the abdomen by gas, so that the scope (usually 6-10 mm in diameter) can view the intra-abdominal contents without being in direct contact with the viscera or tissues. Surgical procedures can be carried out by instruments produced through one or more additional ports.Methods: This study was conducted in 60 patients aged 30-50 years. The patients were divided into two Groups A: 0.5 Bupivacaine, B: Saline intraperitoneal instillation; 30 patients in each group undergoing elective surgery.Results: This study was undertaken to compare the post-operative analgesic effect of 20 mL 0.5% Bupivacaine given intraperitoneally at the end of laparoscopic surgery with control 0.9% saline 20 mL at Bupivacaine group had better postoperative pain relief in the first six hours with no complications.Conclusions: 0.5% Bupivacaine irrigation at the surgical bed is effective for cholecystectomy for postoperative pain relief.