scholarly journals THE STRUCTURE OF ODONTOGENIC INFLAMMATORY DISEASES AT THE OUTPATIENT SURGICAL DENTISTRY

2018 ◽  
Vol 14 (2) ◽  
pp. 78-85 ◽  
Author(s):  
Ирина Костина ◽  
Irina Kostina ◽  
Александр Чернавский ◽  
Aleksandr Chernavskiy ◽  
Михаил Огнев ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Postoperative Period ◽  
Analgesic Effect ◽  
Inflammatory Diseases ◽  
Surgical Techniques ◽  
Pain Syndrome ◽  
Symptomatic Treatment ◽  
Postoperative Pain Relief ◽  
Dental Procedures

Importance. NSAIDs take one of the leading places in drug therapy for postoperative pain relief. They are among the most common medicines used in clinical practice of a dentist. The article presents a comparative clinical evaluation of NSAID analgesic effect in postoperative period of dental surgical techniques. Objective. is to compare the etoricoxib analgesic effect of oral administration in a dosage of 90 mg and nimesulide in dosage of 100 mg in the postoperative period of dental surgical techniques. Methods. Randomized prospective study included 46 patients aged from 20 to 59 years. Two groups of 23 patients (10 men, 13 women in each group) were formed. They were prescribed medications for the pain relief after surgery. Etoricoxib in tablets of 90 mg 1 time a day was prescribed to the patients of the first group. In the second group nimesulide tablets of 100 mg were taken 2 times a day. The patients had taken the pills for three days. Results. Reduction of pain syndrome took place in the first and third day after tooth extraction. The comparison is performed by using visual analogue scale (VAS). Conclusions. Using of etoricoxib as symptomatic treatment of pain syndrome relief after application of surgical dental procedures provides fast, pronounced and long lasting analgesic effect. The drug is effective for preemptive analgesia and also for prevention of inflammatory complications in ambulatory surgical dentistry. It has a favorable safety profile that allows using it extensively in postoperative pain relief.

scholarly journals Multicenter study of the effectiveness of postoperative pain relief in Ukraine using paracetаmol in surgical hospitals – “ROZUM”

Pain medicine ◽  
2021 ◽  
Vol 6 (3) ◽  
pp. 4-14
Author(s):  
Dmytro Dmitriev ◽  
Ya Feleshtynskyi ◽  
S Vasyliuk ◽  
V Shaprynskyi ◽  
Yu Derkach ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Multicenter Study ◽  
Postoperative Period ◽  
Pain Syndrome ◽  
Multimodal Analgesia ◽  
Surgical Patients ◽  
Postoperative Pain Relief

This article is devoted to the effectiveness of postoperative pain relief in surgical hospitals in Ukraine. Multicenter study of the effectiveness of postoperative pain relief in Ukraine using paracetаmol in surgical hospitals – ROZUM is descibed. The effectiveness of multimodal analgesia and other analgesia in the postoperative period has been determined. Predictors of inadequate pain relief in surgical patients were identified, and the risks of pain syndrome development in a surgical hospital were assessed. The use of paracetamol in the schemes of multim

scholarly journals OPRM1 and ABCB1 Polymorphisms and Their Effect on Postoperative Pain Relief With Piritramide

2015 ◽  
pp. S521-S527 ◽  
Author(s):  
O. BARTOŠOVÁ ◽  
O. POLANECKÝ ◽  
F. PERLÍK ◽  
S. ADÁMEK ◽  
O. SLANAŘ
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Adverse Effects ◽  
Postoperative Period ◽  
Receptor Gene ◽  
Early Postoperative Period ◽  
Postoperative Pain Relief ◽  
Intensity Difference ◽  
Pain Intensity Difference ◽  
118G Allele

Genetic factors may contribute to the differential response to opioids. The aim of this study was to evaluate the association between polymorphisms of µ1-opioid receptor gene OPRM1 (rs1799971), and P-glycoprotein transporter gene ABCB1 (rs1045642, rs2032582), and piritramide efficacy under postoperative patient-controlled analgesia (PCA). In 51 patients, OPRM1 variant was associated with decreased efficacy in early postoperative period evidenced by sum of pain intensity difference in the 0-6 h postoperative period (SPID0-6), (F=3.27, p=0.029). Mean (SD) SPID0-6 was observed in the 118AA genotype 22.9 (6.1) mm, which was significantly higher from the 118GG genotype 10.0 (4.4) mm, p=0.006. The lowest cumulative dose was recorded in 118AA genotype 19.1 (9.8) mg, which was significantly less than in the 118GG genotype group 36.6 (6.1) mg, p=0.017. Opioid–induced adverse effects were observed in 11, 30, and 100 % of patients in 118AA, 118AG, and 118GG genotype groups, respectively (p<0.05). Piritramide efficacy and safety was not significantly affected by ABCB1 (rs1045642, rs2032582) polymorphisms. Variant OPRM1 118G allele is associated with decreased acute postoperative pain relief after piritramide. Decreased efficacy leads to higher drug consumption under PCA settings, which however, does not fully compensate insufficient pain relief, but increases incidence of adverse effects.

scholarly journals Irrigation with Bupivacaine at surgical bed for postoperative pain relief after laparoscopic cholecystectomy

2018 ◽  
Vol 5 (4) ◽  
pp. 1538
Author(s):  
Ravishankar N. ◽  
Arun Kumar A. A. ◽  
Tulasi Vasudevaiah
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Laparoscopic Surgery ◽  
Postoperative Pain ◽  
Pain Relief ◽  
Surgical Procedures ◽  
Analgesic Effect ◽  
Direct Contact ◽  
Postoperative Pain Relief ◽  
Intraperitoneal Instillation

Background: Laparoscopy involves insufflation of the abdomen by gas, so that the scope (usually 6-10 mm in diameter) can view the intra-abdominal contents without being in direct contact with the viscera or tissues. Surgical procedures can be carried out by instruments produced through one or more additional ports.Methods: This study was conducted in 60 patients aged 30-50 years. The patients were divided into two Groups A: 0.5 Bupivacaine, B: Saline intraperitoneal instillation; 30 patients in each group undergoing elective surgery.Results: This study was undertaken to compare the post-operative analgesic effect of 20 mL 0.5% Bupivacaine given intraperitoneally at the end of laparoscopic surgery with control 0.9% saline 20 mL at Bupivacaine group had better postoperative pain relief in the first six hours with no complications.Conclusions: 0.5% Bupivacaine irrigation at the surgical bed is effective for cholecystectomy for postoperative pain relief.

The effect of CYP2D6 and CYP2C9 gene polymorphisms on the efficacy and safety of the combination of tramadol and ketorolac used for postoperative pain management in patients after video laparoscopic cholecystectomy

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Andranik Alexandrovich Muradian ◽  
Dmitry Alekseevich Sychev ◽  
Dmitry Alekseevich Blagovestnov ◽  
Zhannet Alimovna Sozaeva ◽  
Kristina Anatolyevna Akmalova ◽  
...  
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Postoperative Pain ◽  
Pain Relief ◽  
Visual Analogue Scale ◽  
Gastrointestinal Bleeding ◽  
Analogue Scale ◽  
Pain Syndrome ◽  
Postoperative Pain Relief ◽  
Mcgill Pain Questionnaire ◽  
Efficacy And Safety

Abstract Objectives One of the key components of ERAS is adequate pain control in the postoperative period. There are no rational schemes for postoperative pain relief. At the same time, adequate postoperative pain relief promotes early activation and early rehabilitation of patients and shortens the duration of the postoperative stay, and does not cause postoperative complications associated with analgesia (weakness, intestinal paresis, nausea and vomiting). The aims of the present study are to assess the possible association of CYP2D6 and CYP2C9 polymorphisms with the efficacy and safety of tramadol and ketorolac in postoperative pain. Methods A total of 107 patients were genotyped for CYP2D6 and CYP2C9 polymorphisms. All patients underwent laparoscopic cholecystectomy. Postoperative pain relief was carried out with ketorolac and tramadol. Postoperative pain syndrome was assessed using a visual analogue scale and McGill pain questionnaire. The profile of side effects was assessed by the dynamics of red blood counts as a possible trigger for the development of gastrointestinal bleeding according to the method of global assessment of triggers. Results Pain was statistically significantly lower in CYP2C9*2 carriers, according to visual analogue scale (VAS): after 12 h – by 1.5 (p=0.002); after 24 h – by 1.1 (p=0.012); after 36 h – by 1.05 (p=0.004); after 48 h – by 0.7 (p=0.026). In CYP2C9*3 carriers the results were not statistically significant. In carriers of CYP2D6*4 pain syndromes were higher at all-time intervals, but statistically reliable results were obtained only after 2 h – by 1.01 (p=0.054) and after 24 h – by 0.8 (p=0.035). The profile of adverse reactions for NSAIDs was evaluated by the dynamics of hemoglobin and erythrocyte indices. A more pronounced decrease in the relative difference in hemoglobin levels was noted in CYP2C9*2 and CYP2C9*3 polymorphism carriers – by 1.7 (p=0.00268) and-by 2.2 (p=0.000143), respectively. Conclusions CYP2D6 and CYP2C9 can predict analgesic effectiveness of tramadol and ketorolac. CYP2C9 can predict the risk of gastrointestinal bleeding, including those hidden to ketorolac.

scholarly journals Analgesic Effect of Intra-Articular Dexamethasone versus Fentanyl added as an adjuvant to Bupivacaine for Postoperative Pain Relief in Knee Arthroscopic Surgery

2021 ◽  
Vol 85 (2) ◽  
pp. 4295-4302
Author(s):  
Hazem El Sayed Moawad Weheba ◽  
Mohamed Ahmed Sultan ◽  
Tawfik Abouhalawa Tawfik Hassan ◽  
Hosam I. El Said Saber
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Analgesic Effect ◽  
Arthroscopic Surgery ◽  
Postoperative Pain Relief

Efficacy of Abductor Pollicis Longus Suspensionplasty Compared to Ligament Reconstruction and Tendon Interposition

Hand ◽  
2020 ◽  
pp. 155894472090656
Author(s):  
Ellen S. Satteson ◽  
Cassie Driscoll ◽  
Mija Khan ◽  
Nicholas J. Walker ◽  
David Person ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Ligament Reconstruction ◽  
Surgical Techniques ◽  
Wound Dehiscence ◽  
Postoperative Pain Relief ◽  
Pinch Strength ◽  
Exact Test ◽  
Abductor Pollicis Longus ◽  
Tendon Interposition

Background: Multiple surgical techniques are described for basal joint osteoarthritis. This study compares clinical outcomes and patient satisfaction with trapeziectomy and abductor pollicis longus (APL) suspensionplasty compared to trapeziectomy with ligament reconstruction and tendon interposition (LRTI) when performed by 2 fellowship-trained hand surgeons. Methods: A retrospective review of 51 consecutive patients undergoing APL suspensionplasty (53 hands) was performed. With this technique, a distally based APL slip is brought through and sewn to the flexor carpi radialis (FCR). The remaining APL is placed in the trapeziectomy void. This technique was compared to 151 patients (166 hands) who underwent LRTI using the FCR tendon. Outcomes assessed included postoperative pain relief, grip and pinch strength, complications, and need for reoperation. Two-tailed, Fisher’s exact test was used for data analysis. Results: APL suspensionplasty resulted in postoperative pain relief in 92.5% (n = 49) compared to 94.0% (n = 156) with LRTI ( P = .758). Mean postoperative grip and pinch strengths with APL suspensionplasty were 41.2 and 10.4 kg, respectively. With LRTI, average grip strength was 42.0 kg, and pinch was 10.1 kg. Both techniques were well tolerated with minimal complications. In the APL group, 1 patient had a postoperative infection requiring drainage. Among the LRTI cases, 1 wound dehiscence required closure, and 2 minor postoperative wound infections resolved with oral antibiotics. Mean follow-up time among APL suspensionplasty patients was 3.3 months compared to 8.4 months following LRTI. Conclusions: APL suspensionplasty is a safe, effective procedure which provides similar pain relief and functional outcomes compared to LRTI.

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