Squamous Cell Carcinoma in the Lacrimal Sac of Young Patient Who Had Conjunctival Squamous Papilloma

Non-keratinizing squamous cell carcinoma (NKSCC) of the lacrimal apparatus is extremely rare. It is usually very aggressive in destroying local tissue and has a grave prognosis for relentless recurrence and distant failures. Though the current evidence cannot make confident recommendations regarding the best management, curative surgical excision with adjuvant radiotherapy remains the most commonly used strategy. Here, we report a 71-year-old woman presented with progressive right medial canthal swellings for six months. A transnasal endoscopic biopsy revealed NKSCC of the lacrimal sac. She then underwent a combination of magnetic resonance images (MRI) and 2-deoxy-2-(18F)fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) for staging purposes. Following cisplatin-based concurrent chemo-radiotherapy (CCRT), the post-treatment PET/CT illustrated the absence of an abnormal metabolic accumulation over the suspicious region as observed in post-treatment CT. A further trans-ostia re-biopsy confirmed complete tumor remission. This case demonstrates the remarkable ability of 18F-FDG PET/CT to differentiate between a persistent malignancy and post-treatment changes. Furthermore, a definite CCRT might provide comparable outcomes to traditional surgery.

Download Full-text

Subungual pigmented squamous cell carcinoma presenting as a grey longitudinal melanonychia in a young patient

BMJ Case Reports ◽

10.1136/bcr-2016-215390 ◽

2016 ◽

pp. bcr2016215390

Author(s):

Michelle Gatica-Torres ◽

Lilia Arguello-Guerra ◽

Juan Manuel Ruiz-Matta ◽

Judith Dominguez-Cherit

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Young Patient ◽

Squamous Cell ◽

Longitudinal Melanonychia

Download Full-text

Histopathological evaluation of tumours and tumour like lesions of skin and adnexa

Journal of Pathology of Nepal ◽

10.3126/jpn.v8i2.20873 ◽

2018 ◽

Vol 8 (2) ◽

pp. 1353-1359

Author(s):

Diksha Karki ◽

Abhimanyu Jha ◽

Shreya Shreevastav ◽

Dinesh B Pokhrel

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Histopathological Examination ◽

Correct Diagnosis ◽

Malignant Tumour ◽

University Teaching ◽

Epidermal Cyst ◽

Squamous Papilloma ◽

Benign Tumours

Background: Tumours and tumour like lesions of skin have overlapping clinical presentation and sometimes pose a diagnostic difficulty on clinical ground alone. Histopathological examination although helpful to arrive at correct diagnosis, at times may be treacherous and may require ancillary tests such as Immunohistochemistry.Materials and Methods: The study was conducted at Department of Pathology of Tribhuvan University Teaching Hospital. It was a one year prospective study which enrolled 238 cases of skin biopsies after histopathological confirmation of tumours and tumour like lesions. The specimens were processed by standard method and Hematoxylin and Eosin stained sections were examined. Data entry and analysis was done by using SPSS 20 version.Results: Epidermal cyst was commonest lesion (11.8%). Among benign tumours squamous papilloma was most frequent while Pilomatricoma and Spiradenoma were most common adnexal tumour. Squamous cell carcinoma constituted 41.8% and was commonest malignant tumour followed by basal cell carcinoma (30.2%). Benign tumours were common in 11-30 years of age, malignant tumours in 61-80 years of age while tumour like lesions were common in 21-30 years of age.Conclusion: Squamous papilloma and squamous cell carcinoma was the most common benign and malignant tumour respectively. Benign adnexal tumours exceeded malignant one and were seen in third decade of life. Epidermal cyst was the commonest tumour like lesions followed by dermoid cysts.

Download Full-text