Histopathological evaluation of tumours and tumour like lesions of skin and adnexa

Background: Tumours and tumour like lesions of skin have overlapping clinical presentation and sometimes pose a diagnostic difficulty on clinical ground alone. Histopathological examination although helpful to arrive at correct diagnosis, at times may be treacherous and may require ancillary tests such as Immunohistochemistry.Materials and Methods: The study was conducted at Department of Pathology of Tribhuvan University Teaching Hospital. It was a one year prospective study which enrolled 238 cases of skin biopsies after histopathological confirmation of tumours and tumour like lesions. The specimens were processed by standard method and Hematoxylin and Eosin stained sections were examined. Data entry and analysis was done by using SPSS 20 version.Results: Epidermal cyst was commonest lesion (11.8%). Among benign tumours squamous papilloma was most frequent while Pilomatricoma and Spiradenoma were most common adnexal tumour. Squamous cell carcinoma constituted 41.8% and was commonest malignant tumour followed by basal cell carcinoma (30.2%). Benign tumours were common in 11-30 years of age, malignant tumours in 61-80 years of age while tumour like lesions were common in 21-30 years of age.Conclusion: Squamous papilloma and squamous cell carcinoma was the most common benign and malignant tumour respectively. Benign adnexal tumours exceeded malignant one and were seen in third decade of life. Epidermal cyst was the commonest tumour like lesions followed by dermoid cysts.

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Squamous papilloma and squamous cell carcinoma arising from epidermal cyst: report of 4 cases

Human Pathology Case Reports ◽

10.1016/j.ehpc.2014.11.008 ◽

2015 ◽

Vol 2 (2) ◽

pp. 55-57

Author(s):

Tadashi Terada

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Epidermal Cyst ◽

Squamous Papilloma

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HISTOPATHOLOGICALANALYSIS OF TUMOURS AND TUMOUR-LIKE LESIONS OF COLON AND RECTUM

10.36106/ijsr/2538967 ◽

2021 ◽

pp. 9-11

Author(s):

Durga Nand Jha ◽

Hari Shankar Mishra ◽

Ajit Kumar Chaudhary ◽

Debarshi Jana

Keyword(s):

Histopathological Examination ◽

Correct Diagnosis ◽

Malignant Tumour ◽

Juvenile Polyp ◽

Tubular Adenoma ◽

Malignant Tumours ◽

Cross Sectional ◽

Colorectal Biopsies ◽

Colon And Rectum ◽

Benign Tumours

Background:Tumours and tumour like lesions of the colon and rectum have overlapping clinical presentation and may be difcult to diagnose on clinical grounds alone. Histopathological examination although helpful to arrive at correct diagnosis, at times may be difcult and may require ancillary tests such as immunohistochemistry. Materials and Methods: A prospective cross sectional study enrolled 125 cases of colorectal biopsies after histopathological conrmation of tumours and tumour like lesions. The specimens were received at the Department of Pathology, DMCH, Laheriasarai, Bihar from December 2019 to November 2020. Results: Out of 125 cases, 32 cases were benign tumours, 36 cases were malignant tumours and 57 cases were tumour like lesions. Most common age range was 51-60 years with mean age of 38 years. Males comprised 76.74% and females 23.26% with ratio of 3:1. Juvenile polyp was the commonest lesion. Among benign tumours, tubular adenoma was the most common (19.2%), adenocarcinoma was most common malignant tumour (25.6%) and juvenile polyp was the most common tumour like lesion (27.2%). Left side was most common side (66.67%) and rectum was the most common site (48.8%). Conclusions: The commonest indications for colorectal biopsies were tumours and tumour like lesions. Juvenile polyp was the most common tumour like lesion, tubular adenoma was the most common benign tumour and adenocarcinoma was the most common malignant tumour. Histopathological examination is a gold standard for conrmation of all tumour and tumours like lesions of colon and rectum.

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Hypertrophic Lichen Planus versus Well-Differentiated Squamous Cell Carcinoma: A Histological Challenge

SKIN The Journal of Cutaneous Medicine ◽

10.25251/10.25251/skin.1.2.6 ◽

2017 ◽

Vol 1 (2) ◽

pp. 91

Author(s):

Samuel P Haslam ◽

Lindy S Ross ◽

Alison C Lowe ◽

Brent C Kelly

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Multiplex Pcr ◽

Lichen Planus ◽

Squamous Cell ◽

Correct Diagnosis ◽

Pseudoepitheliomatous Hyperplasia ◽

Lichen Simplex Chronicus ◽

Well Differentiated

Differentiating hypertrophic lichen planus (LP) from well-differentiated squamous cell carcinoma (SCC) is a histological challenge given the numerous histopathologic similarities between SCC and pseudoepitheliomatous hyperplasia (PEH) arising in the setting of hypertrophic LP. Multiple reports have shown that SCC can arise from hypertrophic LP not infrequently, but that the LP-to-SCC sequence is poorly understood, and many cases defy diagnosis due to histologic similarities. However, there are several clinical clues and histopathologic details that have shown to have some value when trying to ascertain the correct diagnosis. To the contrary, immunohistochemical tests have shown little promise in differentiating hypertrophic LP from SCC. Although multiplex PCR has shown some potential in differentiating PEH from SCC, this has only been in the setting of patients diagnosed with prurigo and lichen simplex chronicus, but not necessarily in the case hypertrophic LP.

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Carcinoma of Vagina in Utero-Vaginal Prolapse: A Rare Presentation

Journal of Nepal Medical Association ◽

10.31729/jnma.75 ◽

2012 ◽

Vol 52 (186) ◽

Cited By ~ 1

Author(s):

S Acharya ◽

DK Uprety

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Histopathological Examination ◽

Large Cell ◽

Uterovaginal Prolapse ◽

Rare Entity ◽

Rare Presentation ◽

Vaginal Carcinoma ◽

Keywords Squamous Cell Carcinoma

Primary vaginal carcinoma in uterovaginal prolapse is a rare entity. We report a case of an 84-years-old lady, who presented with long standing vaginal ulcer in association with third degree uterovaginal prolapse. Incisional biopsy was taken from the ulcer. Histopathological examination showed a large cell keratinizing squamous cell carcinoma. Keywords: Squamous cell carcinoma, uterovaginal prolapse, vaginal carcinoma.

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A HISTOPATHOLOGICAL STUDY OF LIMB LESIONS: RETROSPECTIVE STUDY AT RIMS, RANCHI

10.36106/ijar/8603393 ◽

2021 ◽

pp. 13-14

Author(s):

Suraj Sinha ◽

Suchitra Kumari ◽

Rabindra Kumar Singh ◽

Raj Kishor Kumar

Keyword(s):

Squamous Cell Carcinoma ◽

Retrospective Study ◽

Cell Carcinoma ◽

Squamous Cell ◽

Benign Lesion ◽

Malignant Neoplasm ◽

Pyogenic Granuloma ◽

Epidermal Cyst ◽

Histopathological Study ◽

Bony Lesion

Limb lesions of skin, soft tissue and bone are commonly encountered. They include a multitude of non neoplastic, benign and malignant diseases ranging from lipoma to brosarcoma and from epidermal cyst to squamous cell carcinoma. An insight of the pattern of various limb diseases in relation to site, age, and type of lesion assists in better comprehension of differential diagnosis for histopathologists. A retrospective study of histopathologically diagnosed cases of Material & Methods: 47 limb lesion patients from June 2020 to May 2021 was undertaken. A total 47 cases included 28 male and 19 female, Results: 55% of cases belong to age group 21 to 50 years. 13 (28%) cases were of upper extremity and 34 (72%) from lower extremity. 15 (34%) cases were non-neoplastic, 13 (28%) were benign lesion and rest 19 (38%) were malignant lesions. Lower limb lesions are more common than Conclusion: upper limb lesions. Squamous cell carcinoma is the most common malignant neoplasm and lipoma is the most common benign disease of extremity. Pyogenic granuloma and epidermal cyst were found to be the most common non-neoplastic extremity lesions. Fibrosarcoma was the most common type of sarcoma observed in 9% cases. Chronic osteomyelitis was the most common bony lesion.

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A case report of an unusual caecal metastatic location of a primary cervical squamous cell carcinoma

Journal of Surgical Case Reports ◽

10.1093/jscr/rjaa443 ◽

2020 ◽

Vol 2020 (10) ◽

Author(s):

Obed Rockson ◽

Christine Kora ◽

Abdelbassir Ramdani ◽

Badr Serji ◽

Tijani El Harroudi

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Histopathological Examination ◽

Management Strategies ◽

Cervical Squamous Cell Carcinoma ◽

Right Hemicolectomy ◽

Secondary Lesion ◽

The Right ◽

Metastatic Location

Abstract Squamous cell carcinoma (SCC) of the colon is a rare malignant tumor occurring as either a primary or secondary lesion. Few cases of metastatic or secondary colonic SCC have been published. We report an unusual case of a 59-year-old female patient who was treated by Wertheim hysterectomy and adjuvant chemoradiation for stage IIB SCC of the uterine cervix. Two years later, she developed a metastatic location in the caecum causing an acute intestinal obstruction. She underwent an emergency open right hemicolectomy with ileocolic anastomosis and resection of two nodules of the umbilicus and the right parietal peritoneum. Histopathological examination confirmed a triple metastatic location of SCC. She is disease-free 11 months after surgery. We discuss the clinicopathological features, management strategies, and the prognosis of this rare entity.

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The metastatic dissemination of a squamous cell carcinoma arising from an epidermal cyst and subsequent failure to respond to programmed death 1 inhibition

JAAD Case Reports ◽

10.1016/j.jdcr.2019.01.032 ◽

2019 ◽

Vol 5 (4) ◽

pp. 375-378

Author(s):

Melissa A. Lumish ◽

Mark A. Anderson ◽

Patrick S. Rush ◽

Florian J. Fintelmann ◽

Lyn Duncan ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Epidermal Cyst ◽

Metastatic Dissemination ◽

Programmed Death ◽

Programmed Death 1 ◽

Subsequent Failure

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Two different clinical forms of squamous cell carcinoma (SCC) in the perineum and vulva of two mares

BMC Veterinary Research ◽

10.1186/s12917-020-02678-9 ◽

2020 ◽

Vol 16 (1) ◽

Author(s):

Andrzej Raś ◽

Iwona Otrocka-Domagała ◽

Małgorzata Raś-Noryńska

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Ultrasound Examination ◽

Histopathological Examination ◽

Reproductive Organs ◽

Malignant Neoplasms ◽

Surgical Removal ◽

Chemotherapy Treatment ◽

Case Presentation

Abstract Background Genital malignant neoplasms in mares are relatively rare. The treatment involve surgical removal of the tumour masses, chemotherapy or both. Case presentation Two elderly warmblood mares, aged 16 and 20 were presented in University Clinic with the lumpy lesions at the region of perineum and left labia. Surgical removals of tumour masses were performed on standing animals. Removed tissues were subjected to histopathological examination which confirmed SCC. Conclusions Clinical and ultrasound examination of reproductive organs in both mares showed no inflammatory or neoplastic changes. Both mares healed within 2 weeks after surgery and showed no signs of tumour recurrence for the following year despite no chemotherapy treatment.

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