scholarly journals DISTRIBUTION OF TYPES OF PSYCHOLOGICAL RESPONSE TO THE DISEASE IN DIFFERENT GROUPS OF PATIENTS WITH CHRONIC PHASE OF ISCHEMIC STROKE

2021 ◽  
Vol 7 (1-2) ◽  
pp. 7-14
Author(s):  
A.M. Babirad
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Cholesterol Level ◽  
Chronic Phase ◽  
Chronic Cerebral Ischemia ◽  
Ischemic Lesion ◽  
Psychological Response ◽  
Gender And Education ◽  
Personal Questionnaire ◽  
Lesion Severity

The objective of our research was to study the types of psychological response to the disease in different groups of patients with chronic phase of ischemic stroke. Material and methods. 100 consecutive patients with chronic phase of ischemic stroke and 17 patients with chronic cerebral ischemia were questioned in neurology in-patient department. The types of attitude towards disease were identified with the help of the Personal Questionnaire of the Bekhterev Institute. Results. Our data indicate that clinical (location of the ischemic lesion, severity of paresis), laboratory (cholesterol level) and individual (gender and education) factors are involved in the formation of the internal picture of the disease in patients with chronic phase of ischemic stroke. Keywords: ischemic stroke, the Personal Questionnaire of the Bekhterev Institute, attitudes towards disease.

scholarly journals ATTITUDES TOWARDS DISEASE IN PATIENTS WITH CHRONIC PHASE OF ISCHEMIC STROKE BY THE RESULTS OF THE PERSONAL QUESTIONNAIRE OF THE BEKHTEREV INSTITUTE

2020 ◽  
Vol 6 (3-4) ◽  
pp. 19-26
Author(s):  
A.M. Babirad
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Chronic Phase ◽  
Complete Recovery ◽  
Chronic Cerebral Ischemia ◽  
Personal Questionnaire ◽  
Patient Department

Every year, strokes are diagnosed in about 16 million people, of whom 5.7 million die and about the same number become disabled (Feigin V.L., Forouzanfar M.H., Krishnamurthi R., et al., 2014; Virani S.S., Alonso A., Benjamin E.J., et al., 2020; Kim J., Thayabaranathan T., Donnan G.A., et al. 2020). The objective of our research was to study the attitudes towards disease in patients with chronic phase of ischemic stroke. Material and methods. 100 consecutive patients with chronic phase of ischemic stroke and 17 patients with chronic cerebral ischemia were questioned in neurology in-patient department. The types of attitude towards disease were identified with the help of the Personal Questionnaire of the Bekhterev Institute. Results. We found that pathological types of attitude towards disease begin to form before the development of a stroke as a result of chronic cerebral ischemia. Among patients with chronic phase of ischemic stroke, pathological types of attitude towards disease prevailed significantly, and the harmonious type was rare (84.0% vs 16.0%, p < 0.001). The most frequently observed were neurasthenic (36.0%), harmonious (16.0%), anxious (16.0%), ergopathic (10.0%) and sensitive (8.0%) types of attitude towards disease. Our study has shown that any ischemic stroke, even in the case of complete recovery of the lost functions, can be associated with pathological types of attitude towards disease. Keywords: ischemic stroke, the Personal Questionnaire of the Bekhterev Institute, attitudes towards disease.

scholarly journals Features of epilepsy in acute and chronic cerebral ischemia

2017 ◽  
Vol 98 (6) ◽  
pp. 877-883
Author(s):  
T V Danilova
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Right Hemisphere ◽  
Epileptic Seizures ◽  
Risk Groups ◽  
Cerebrovascular Reactivity ◽  
Circulation System ◽  
Chronic Cerebral Ischemia ◽  
Ischemic Lesion ◽  
The Brain

Aim. To study clinical features, functional and neuroimaging characteristics of the brain of patients with ischemic brain disease and epileptic seizures. Methods. 772 patients with acute and chronic cerebral ischemia (265 stroke patients with epileptic seizures and 174 patients with seizures on the background of chronic cerebral ischemia, and 203 patients with stroke and 130 patients with chronic cerebral ischemia without seizures) were comprehensively examined. The clinical neurological examination, electroencephalography, magnetic resonance imaging, ultrasound duplex scanning of extra- and intracranial arteries with the assessment of the level and degree of stenosis and cerebrovascular reactivity were carried out. Results. Focal seizures prevailed in patients with cerebral ischemia. In patients with epileptic seizures on the background of both ischemic stroke and chronic cerebral ischemia cortical localization of ischemic foci prevailed. Early epileptic seizures in patients with ischemic stroke developed with significantly more frequent localization of ischemic focus in the right hemisphere with the orientation vector of neuroimaging formation of the ischemic lesion in the caudal direction. In patients with chronic cerebral ischemia with epileptic seizures, along with frequent lesion of the cortex, more frequent damage of white matter of the brain was observed. In patients with acute and chronic ischemia of the brain with epileptic seizures, a higher incidence of stenosis of major arteries and predominance of impaired cerebrovascular reactivity in posterior cerebral circulation system were established. Conclusion. Multimodal examination of patients with acute and chronic cerebral ischemia allowed forming risk groups for epileptic seizures.

Gene and Stem Cell Therapy in Ischemic Stroke

2009 ◽  
Vol 18 (9) ◽  
pp. 999-1002 ◽  
Author(s):  
Toru Yamashita ◽  
Kentaro Deguchi ◽  
Shoko Nagotani ◽  
Tatsushi Kamiya ◽  
Koji Abe
Keyword(s):  
Stem Cell ◽  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Neuroprotective Effect ◽  
Chronic Phase ◽  
Artery Occlusion ◽  
Ischemic Brain ◽  
Gdnf Gene

Possible strategies for treating ischemic stroke include neuroprotection (preventing injured neurons from undergoing apoptosis in the acute phase of cerebral ischemia) and stem cell therapy (the repair of disrupted neuronal networks with newly born neurons in the chronic phase of cerebral ischemia). First, we estimated the neuroprotective effect of glial cell line-derived neurotrophic factor (GDNF) by administration of GFNF protein. GDNF protein showed a direct protective effect against ischemic brain damage. Pretreatment of animals with adenoviral vector containing GDNF gene (Ad-GDNF) 24 h before the subsequent transient middle cerebral artery occlusion (MCAO) effectively reduced infarcted volume. Secondly, we studied the neuroprotective effect of a calcium channel blocker, azelnidipine, or a by-product of heme degradation, biliverdin. Both azelnidipine and biliverdin had a neuroprotective effect in the ischemic brain through their antioxidative property. Lastly, we developed a restorative stroke therapy with a bioaffinitive scaffold, which is able to provide an appropriate platform for newly born neurons. In the future, we will combine these strategies to develop more effective therapies for treatment of strokes.

Characteristics of microcirculation in patients with acute ischemic stroke and chronic cerebral ischemia

2015 ◽  
Vol 115 (3) ◽  
pp. 27 ◽  
Author(s):  
A. V. Anisimova ◽  
A. I. Krupatkin ◽  
V. V. Sidorov ◽  
M. V. Zakharkina ◽  
E. V. Yutskova ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Acute Ischemic Stroke ◽  
Chronic Cerebral Ischemia

Citimax-Darnitsa in the treatment of patients with chronic cerebral ischemia

2017 ◽  
Vol 0 (1.87) ◽  
pp. 117-122
Author(s):  
O.L. Tovazhnianska ◽  
I.O. Lapshina ◽  
A.H. Chernenko ◽  
O.I. Kauk
Keyword(s):  
Cerebral Ischemia ◽  
Chronic Cerebral Ischemia

scholarly journals A novel voxel-wise lesion segmentation technique on 3.0-T diffusion MRI of hyperacute focal cerebral ischemia at 1 h after permanent MCAO in rats

2017 ◽  
Vol 38 (8) ◽  
pp. 1371-1383 ◽  
Author(s):  
Chi-Hoon Choi ◽  
Kyung Sik Yi ◽  
Sang-Rae Lee ◽  
Youngjeon Lee ◽  
Chang-Yeop Jeon ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Region Of Interest ◽  
Artery Occlusion ◽  
Lesion Segmentation ◽  
Ischemic Lesion ◽  
Segmentation Technique ◽  
Apparent Diffusion ◽  
Relative Threshold ◽  
Cerebral Ischemic

To assess hyperacute focal cerebral ischemia in rats on 3.0-Tesla diffusion-weighted imaging (DWI), we developed a novel voxel-wise lesion segmentation technique that overcomes intra- and inter-subject variation in apparent diffusion coefficient (ADC) distribution. Our novel technique involves the following: (1) intensity normalization including determination of the optimal type of region of interest (ROI) and its intra- and inter-subject validation, (2) verification of focal cerebral ischemic lesions at 1 h with gross and high-magnification light microscopy of hematoxylin-eosin (H&E) pathology, (3) voxel-wise segmentation on ADC with various thresholds, and (4) calculation of dice indices (DIs) to compare focal cerebral ischemic lesions at 1 h defined by ADC and matching H&E pathology. The best coefficient of variation was the mode of the left hemisphere after normalization using whole left hemispheric ROI, which showed lower intra- (2.54 ± 0.72%) and inter-subject (2.67 ± 0.70%) values than the original. Focal ischemic lesion at 1 h after middle cerebral artery occlusion (MCAO) was confirmed on both gross and microscopic H&E pathology. The 83 relative threshold of normalized ADC showed the highest mean DI (DI = 0.820 ± 0.075). We could evaluate hyperacute ischemic lesions at 1 h more reliably on 3-Tesla DWI in rat brains.

scholarly journals Associations of Ischemic Lesion Volume With Functional Outcome in Patients With Acute Ischemic Stroke

Stroke ◽  
2017 ◽  
Vol 48 (5) ◽  
pp. 1233-1240 ◽  
Author(s):  
Amber Bucker ◽  
Anna M. Boers ◽  
Joseph C.J. Bot ◽  
Olvert A. Berkhemer ◽  
Hester F. Lingsma ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Functional Outcome ◽  
Lesion Volume ◽  
Ischemic Lesion

scholarly journals Quantitation of Photochemically Induced Focal Cerebral Ischemia in the Rat

1988 ◽  
Vol 8 (1) ◽  
pp. 89-95 ◽  
Author(s):  
John J. Grome ◽  
Gerlinde Gojowczyk ◽  
Wolfgang Hofmann ◽  
David I. Graham
Keyword(s):  
Cerebral Ischemia ◽  
Water Content ◽  
Rose Bengal ◽  
Tissue Damage ◽  
Focal Cerebral Ischemia ◽  
Ischemic Damage ◽  
Brain Water Content ◽  
Ischemic Insult ◽  
Ischemic Lesion ◽  
Brain Water

This study was carried out with a recently developed model of focal cerebral ischemia in the rat based on the photochemical induction of thrombotic stroke using the dye Rose Bengal. We examined the change in the volume of the lesion and brain water content, in separate groups of rats, at different times (1, 4, 24, 72, and 168 h) after the induction of the ischemic lesion. The volume of ischemic damage increased rapidly between 1 and 24 h after the ischemic insult and decreased between 24 and 168 h. The lesion at 168 h was significantly larger than that following 1 h of ischemia and similar to that obtained at 4 h, suggesting that the maximum extent of tissue damage (without the involvement of significant edema) was reached within the first 4 h in this model. The enlargement of the lesion after 4 h correlated closely with changes in brain water content.

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