scholarly journals Diferentes aspectos da resposta imunológica na COVID-19

2021 ◽  
Vol 10 (14) ◽  
pp. e423101422531
Author(s):  
Ana Alice Reis Santos ◽  
Karen Kaori Onishi de Paula ◽  
Bruno Fernando Daneli Marasco ◽  
Daniele Gonçalves Castilho
Keyword(s):  
England Journal ◽  
New England ◽  
Google Scholar

Durante a pandemia da COVID-19, infecção pelo vírus SARS-CoV-2, o qual provoca síndrome respiratória grave. Diferente de outras infecções virais, sua resposta a inflamação diverge do comum, assim se tornou um enigma para compreender o funcionamento celular durante a resposta imunológica. Sendo assim muitos estudos permitiram iniciar a elucidação a partir das células principais, TCD4, TCD8, Linfócitos B e Anticorpos. Esta revisão tem como objetivo buscar em artigos e pesquisas cientificas relacionadas ao tema, via bases de dados como: Google Scholar, Elsevier, PubMed, Medline, The New England Journal of Medicine e Scielo, textos relacionados às características gerais do COVID-19 e a imunologia relacionada à infecção pelo vírus SARS-CoV-2. Embora mais estudos sejam necessários, uma imagem começou a emergir que revela que Células TCD4 +, células TCD8 + e anticorpos neutralizantes, contribuem para o controle de SARS-CoV-2 em ambos os casos não hospitalizados e hospitalizados de COVID-19. As funções específicas e cinética destes adaptativos as respostas imunes são discutidas, bem como sua interação com a imunidade inata e implicações para COVID-19 vacinas e memória imunológica contra reinfecção, deve-se lembrar que mesmo com as conclusões supracitas, hoje existem variantes do vírus, as quais fazem repensar sobre a eficácia da imunidade de rebanho e imunidade geral, pois elas podem ser mais transmissíveis e mais resistentes a vacinas. Sendo assim ressaltamos a importância de manter os cuidados relacionados a higiene e proteção, seguindo o recomendado pelas agências de saúde mundiais.

Molekularbiologie

2018 ◽  
Vol 09 (05) ◽  
pp. 242-243
Author(s):  
Dr. Susanne Krome
Keyword(s):  
England Journal ◽  
Medical School ◽  
New England ◽  
Harvard Medical School

Zehntausende nichtproteinkodierende RNAs haben die Kenntnisse über die normale Physiologie sowie die Entstehung und Behandlung von Krankheiten auf den Kopf gestellt, schreibt Prof. Frank Slack, Harvard Medical School, Boston/USA, im New England Journal of Medicine über den überwiegenden Teil unseres Genoms. Diese RNA-Sub typen regulieren Wachstum, Entwicklung und Organfunktion. Ihre Gewebespezifität eröffnet neue, unerwartete Möglichkeiten in der Onkologie. Der größte Teil ihrer Funktionen ist allerdings noch nicht erforscht.

New editor takes charge at New England Journal of Medicine

BMJ ◽  
1999 ◽  
Vol 319 (7211) ◽  
pp. 662-662 ◽  
Author(s):  
J. H. Tanne
Keyword(s):  
England Journal ◽  
New England

CLINICAL CONFERENCE

PEDIATRICS ◽  
1958 ◽  
Vol 22 (5) ◽  
pp. 1016-1022
Author(s):  
Saul Krugman ◽  
Robert Ward
Keyword(s):  
England Journal ◽  
New England ◽  
Gamma Globulin ◽  
Infectious Hepatitis ◽  
Progress Report ◽  
State School ◽  
Staten Island ◽  
Active Immunity ◽  
History Of ◽  
Time Of Admission

Dr. Krugman: Since 1953 approximately 400 cases of infectious hepatitis with jaundice have been observed at the Willowbrook State School on Staten Island. The studies to be described were carried out in collaboration with Dr. Robert Ward and Dr. Joan Giles of our staff, Dr. A. Milton Jacobs of Willowbrook State School and Dr. Oscar Bodansky of Sloan-Kettering Institute. I should like to present a progress report of our investigations which have been concerned with the prevention and natural history of infectious hepatitis at Willowbrook. (A report of these studies has recently appeared in the New England Journal of Medicine (248:407, 1958) to which the reader may refer for further details.) It had been previously reported by Stokes and associates that the administration of gamma-globulin was followed by not only a lower incidence of hepatitis but also a prolongation of the protective effect. Stokes postulated that "passive-active" immunity was responsible for this phenomenon. The epidemic of hepatitis at Willowbrook provided us with an opportunity to test this hypothesis. Effect of Gamma-globulin on the Frequency of Infectious Hepatitis. Figure 1 illustrates the course of the outbreak at Willowbrook beginning in January, 1955. As can be seen, hepatitis continued to occur at a rate of about two to three cases per week. The cases, predominantly in children, occurred in 18 buildings in the institution. In June of 1956 gamma-globulin, 0.01 ml/lb, was administered to approximately a third of the inmates of each building. The control and inoculated groups were comparable as to age and time of admission to Willowbrook.

Biostatistics in Pediatrics

PEDIATRICS ◽  
1984 ◽  
Vol 73 (1) ◽  
pp. 117-118
Author(s):  
KENNETH W. KLESH
Keyword(s):  
Medical Education ◽  
England Journal ◽  
New England ◽  
Continuing Medical Education ◽  
Recent Article ◽  
Medical Literature ◽  
Education Effort

To the Editor.— I read with great interest the recent article by Hayden1 concerning the expanding use (and misuse) of biostatistics. in the medical literature. Having little background in statistics, I indeed have found it increasingly difficult to critically evaluate research presentations—the "auto-cerebrectomy" of which Feinstein2 spoke is both familiar and personally troubling. While a series of instructional articles on statistical topics as has appeared in the New England Journal of Medicine, is most welcome, I suspect that an approach more intimately associated with a well-established continuing medical education effort would reach the greatest number of practicing pediatricians and could be more directly tailored to their needs.

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