CLINICAL CONFERENCE

PEDIATRICS ◽  
1958 ◽  
Vol 22 (5) ◽  
pp. 1016-1022
Author(s):  
Saul Krugman ◽  
Robert Ward
Keyword(s):  
England Journal ◽  
New England ◽  
Gamma Globulin ◽  
Infectious Hepatitis ◽  
Progress Report ◽  
State School ◽  
Staten Island ◽  
Active Immunity ◽  
History Of ◽  
Time Of Admission

Dr. Krugman: Since 1953 approximately 400 cases of infectious hepatitis with jaundice have been observed at the Willowbrook State School on Staten Island. The studies to be described were carried out in collaboration with Dr. Robert Ward and Dr. Joan Giles of our staff, Dr. A. Milton Jacobs of Willowbrook State School and Dr. Oscar Bodansky of Sloan-Kettering Institute. I should like to present a progress report of our investigations which have been concerned with the prevention and natural history of infectious hepatitis at Willowbrook. (A report of these studies has recently appeared in the New England Journal of Medicine (248:407, 1958) to which the reader may refer for further details.) It had been previously reported by Stokes and associates that the administration of gamma-globulin was followed by not only a lower incidence of hepatitis but also a prolongation of the protective effect. Stokes postulated that "passive-active" immunity was responsible for this phenomenon. The epidemic of hepatitis at Willowbrook provided us with an opportunity to test this hypothesis. Effect of Gamma-globulin on the Frequency of Infectious Hepatitis. Figure 1 illustrates the course of the outbreak at Willowbrook beginning in January, 1955. As can be seen, hepatitis continued to occur at a rate of about two to three cases per week. The cases, predominantly in children, occurred in 18 buildings in the institution. In June of 1956 gamma-globulin, 0.01 ml/lb, was administered to approximately a third of the inmates of each building. The control and inoculated groups were comparable as to age and time of admission to Willowbrook.

Infectious hepatitis: protection by immunoglobulin

1970 ◽  
Vol 8 (9) ◽  
pp. 33-34
Keyword(s):  
Gamma Globulin ◽  
Virus Antigen ◽  
Infectious Hepatitis ◽  
Specific Antibodies ◽  
Active Immunity ◽  
Viral Illness

Although the virus has not yet been isolated, all the available evidence suggests that infectious hepatitis is a viral illness. Failure to isolate the virus or viruses responsible means that specific antibodies to the virus antigen cannot be produced in the laboratory, neither can the virus be modified artificially and used to evoke active immunity. After an attack of infectious hepatitis an individual is usually immune from further attacks; the antibodies responsible for the immunity are contained in IgG fractions of the gamma globulin.

Of Research Cycles and Publication Models

2016 ◽  
Vol 14 (4) ◽  
pp. 1076-1079
Author(s):  
Kirstie M. McClure
Keyword(s):  
England Journal ◽  
New England ◽  
Biomedical Research ◽  
Academic Discipline ◽  
Publishing History ◽  
Professional Norms ◽  
Editorial Practice ◽  
History Of ◽  
The 1960S

This response to Prof. Lieberman’s essay questions its analogy between “biomedical research” and the academic discipline of political science. Focused on the disanalogy of scope and scale between the two, it takes issue not with the “criterial framework” he offers, but with the quality of argumentation that leads us there. Supplementing the essay’s impressionistic account of editorial practice with evidence drawn from the New England Journal of Medicine and the publishing history of APSA journals since the 1960s, I suggest that the issue here is not simply editorial virtue and professional norms, but differences in the material and institutional bases of the journals’ alternative publication models.

Response to Symposium Reviewers

2016 ◽  
Vol 14 (4) ◽  
pp. 1080-1082
Author(s):  
Evan S. Lieberman
Keyword(s):  
England Journal ◽  
New England ◽  
Biomedical Research ◽  
Academic Discipline ◽  
Publishing History ◽  
Professional Norms ◽  
Editorial Practice ◽  
History Of ◽  
The 1960S

This response to Prof. Lieberman’s essay questions its analogy between “biomedical research” and the academic discipline of political science. Focused on the disanalogy of scope and scale between the two, it takes issue not with the “criterial framework” he offers, but with the quality of argumentation that leads us there. Supplementing the essay’s impressionistic account of editorial practice with evidence drawn from the New England Journal of Medicine and the publishing history of APSA journals since the 1960s, I suggest that the issue here is not simply editorial virtue and professional norms, but differences in the material and institutional bases of the journals’ alternative publication models.

Molekularbiologie

2018 ◽  
Vol 09 (05) ◽  
pp. 242-243
Author(s):  
Dr. Susanne Krome
Keyword(s):  
England Journal ◽  
Medical School ◽  
New England ◽  
Harvard Medical School

Zehntausende nichtproteinkodierende RNAs haben die Kenntnisse über die normale Physiologie sowie die Entstehung und Behandlung von Krankheiten auf den Kopf gestellt, schreibt Prof. Frank Slack, Harvard Medical School, Boston/USA, im New England Journal of Medicine über den überwiegenden Teil unseres Genoms. Diese RNA-Sub typen regulieren Wachstum, Entwicklung und Organfunktion. Ihre Gewebespezifität eröffnet neue, unerwartete Möglichkeiten in der Onkologie. Der größte Teil ihrer Funktionen ist allerdings noch nicht erforscht.

scholarly journals The City-State of Boston: The Rise and Fall of an Atlantic Power, 1630–1865

2020 ◽  
Vol 94 (3) ◽  
pp. 631-636
Author(s):  
Noam Maggor
Keyword(s):  
New England ◽  
British Empire ◽  
American Revolution ◽  
Regional Autonomy ◽  
Atlantic Trade ◽  
History Of ◽  
British Colonial ◽  
City State ◽  
The City ◽  
American Nation

Mark Peterson's The City-State of Boston is a formidable work of history—prodigiously researched, lucidly written, immense in scope, and yet scrupulously detailed. A meticulous history of New England over more than two centuries, the book argues that Boston and its hinterland emerged as a city-state, a “self-governing republic” that was committed first and foremost to its own regional autonomy (p. 6). Rather than as a British colonial outpost or the birthplace of the American Revolution—the site of a nationalist struggle for independence—the book recovers Boston's long-lost tradition as a “polity in its own right,” a fervently independent hub of Atlantic trade whose true identity placed it in tension with the overtures of both the British Empire and, later, the American nation-state (p. 631).

Sign in / Sign up

Export Citation Format

Share Document