Heart-type Fatty Acid Binding Protein as an Adjunct to Cardiac Troponin-I for the Diagnosis of Myocardial Infarction

Abstract Objectives: To determine the role of heart fatty acid-binding protein in early detection of non-ST-elevation myocardial infarction and its comparison with two other cardiac markers. Methods: The cross-sectional study was conducted at Abbasi Shaheed Hospital, Karachi, from June 2012 to June 2014, and comprised patients presenting at the emergency department within two hours of chest pain and who were subsequently referred to the cardiology department with a provisional diagnosis of either unstable angina or non-ST-elevation myocardial infarction. Relevant history was taken on a specific proforma and electrocardiogram as well as routine investigations were done in the emergency department. Blood samples from the subjects were tested for the diagnosis of myocardial infarction through detection of heart fatty acid-binding protein, Troponin-I and Creatine kinase-myocardial band. Sensitivity and specificity of the three markers were calculated keeping coronary angiography as the gold standard. Data was analysed using SPSS 17. Results: Out of 250 patients, 153(61.2%) were males. The overall mean age was 54.45±13.92 years. Sensitivity and specificity of heart fatty acid-binding protein were 80.6% and 78.5% (p<0.05), for Troponin-I, 37.7% and 75% (p>0.05), and for Creatine Kinase-myocardial band, 29.5% and 67.8% (p>0.05). Conclusion: Heart fatty acid-binding protein was found to be a good diagnostic tool for the detection of non-ST-elevation myocardial infarction. Key Words: Non ST-elevation myocardial infarct, Cardiac markers, Heart fatty acid-binding protein, Troponin-I, Creatine kinase isoenzyme MB, Angiography. Continuous...

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Rapidly rule out acute myocardial infarction by combining copeptin and heart-type fatty acid-binding protein with cardiac troponin

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/0004563215578189 ◽

2015 ◽

Vol 52 (5) ◽

pp. 550-561 ◽

Cited By ~ 15

Author(s):

Leo HJ Jacobs ◽

Marcel van Borren ◽

Eugenie Gemen ◽

Martijn van Eck ◽

Bas van Son ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Fatty Acid ◽

Cardiac Troponin ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Fatty Acid Binding ◽

Acid Binding Protein ◽

Rule Out

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Comparison of Co-Peptin, Heart Fatty Acid Binding Protein, Troponin-I and CK-MB Assays as Diagnostic Biomarkers in Patients with Myocardial Infarction

International Journal of Science and Research (IJSR) ◽

10.21275/v5i4.nov162700 ◽

2016 ◽

Vol 5 (4) ◽

pp. 1040-1043

Keyword(s):

Myocardial Infarction ◽

Fatty Acid ◽

Fatty Acid Binding Protein ◽

Troponin I ◽

Binding Protein ◽

Fatty Acid Binding ◽

Diagnostic Biomarkers ◽

Acid Binding Protein

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The potential role of a turbidimetric heart-type fatty acid-binding protein assay to aid in the interpretation of persistently elevated, non-changing, cardiac troponin I concentrations

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2018.05.006 ◽

2018 ◽

Vol 58 ◽

pp. 53-59 ◽

Cited By ~ 7

Author(s):

Peter A. Kavsak ◽

Craig Ainsworth ◽

Donald M. Arnold ◽

Terry Scott ◽

Lorna Clark ◽

...

Keyword(s):

Fatty Acid ◽

Cardiac Troponin ◽

Fatty Acid Binding Protein ◽

Potential Role ◽

Troponin I ◽

Cardiac Troponin I ◽

Fatty Acid Binding ◽

Protein Assay ◽

Acid Binding Protein

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Diagnostic performance of heart-type fatty acid binding protein and high sensitive-cardiac troponin in patients in an emergency department sus-pected of acute myocardial infarction

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v10i2.372 ◽

2019 ◽

Vol 10 (2) ◽

pp. 1002-1006

Author(s):

Bashar J Hussein ◽

Basil O Saleh ◽

Nazar N Abbas

Keyword(s):

Myocardial Infarction ◽

Fatty Acid ◽

Chest Pain ◽

Cardiac Troponin ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Fatty Acid Binding ◽

Acid Binding Protein ◽

The Mean ◽

Polypeptide Structure

Heart-type fatty acid binding protein (H-FABP) also referred to as mammary derived growth inhibitor is a polypeptide structure that in humans transcribed by FABP3 gene. It is preferred to be investigated in combination with troponin to the diagnosis of myocardial infarction in patients suffering from chest pain. This study aims to evaluate the role of H FABP in early diagnosis of MI in comparison with new generation cardiac troponin (hs-c'Tn) and to differentiate patients with ischemic chest pain from non-ischemic ones. This case-control study was performed at the Department of Biochemistry, Medical school, University of Baghdad, during the period from December 2017 to August 2018. It involved 36 patients presented with chest pain; 18 ischemic patients (AMI) and 18 non- ischemic patients (non-AMI) who served as pathological control. Serum investigations included measurements of FABP and hs-c'I'n using enzyme-linked immunosorbent assay (ELISA) method. The mean (±SD) value of serum FABP levels at 1-3 hours did not differ significantly between ischemic and non- ischemic subjects, while it was significantly increased at 6-9 hours in ischemic patients (p< 0.001). However, the mean value of serum levels of hs-c'I'n was significantly higher in AMI patients than in non- AMI ones at 1-3 hours (p<O.0. 04) and 6-9 hours (u<O.o. m). The results concluded that serum hs-c'Tn still the best biochemical marker in confirming the diagnosis of early acute MI and is superior of H-FABP in the rule in and rule out of MI.

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