Abstract
Background: Since potential link between statin and the risk of adverse chronic periodontitis (CP) has been raised, we aimed to validate the associations of statin use on the incidence of CP using a nationwide cohort data. Methods: This longitudinal follow-up study included 169,381 patients who were administered statins matched with an equal number of controls using propensity score from the Korean National Health Insurance Service-Health Screening Cohort database (2002–2015). A Cox proportional hazard model was used to assess the occurrence of CP following statin use after adjusting for multiple covariates.Results: The occurrence of CP was significantly higher with long-term use (1–3 years, 3–5 years, or >5 years) than with short-term use (≤1 year). After adjustment, statin users exhibited a 1.32-fold higher occurrence of CP (95% confidence interval=1.30–1.33) than the matched non-users (incidence: 25.0 and 22.0 per 100 person-years, respectively). Subgroup analyses supported the adverse impact of statins on CP independent of age and sex.Conclusions: Statin use in individuals aged >40 years, of both sexes, may slightly increase the risk of occurrence of CP, especially with long-term use, warranting a caution regarding the onset of CP as a possible adverse effect of long-term statin use.
Treatment Gap in the National Health-screening Program in Korea: Claim-based Follow-up of Statin Use for Sustained Hypercholesterolemia
