Association Between Statin use and Chronic Periodontitis: A Longitudinal Follow-Up Study using Korean National Health Screening Cohort

Abstract Background: Since potential link between statin and the risk of adverse chronic periodontitis (CP) has been raised, we aimed to validate the associations of statin use on the incidence of CP using a nationwide cohort data. Methods: This longitudinal follow-up study included 169,381 patients who were administered statins matched with an equal number of controls using propensity score from the Korean National Health Insurance Service-Health Screening Cohort database (2002–2015). A Cox proportional hazard model was used to assess the occurrence of CP following statin use after adjusting for multiple covariates.Results: The occurrence of CP was significantly higher with long-term use (1–3 years, 3–5 years, or >5 years) than with short-term use (≤1 year). After adjustment, statin users exhibited a 1.32-fold higher occurrence of CP (95% confidence interval=1.30–1.33) than the matched non-users (incidence: 25.0 and 22.0 per 100 person-years, respectively). Subgroup analyses supported the adverse impact of statins on CP independent of age and sex.Conclusions: Statin use in individuals aged >40 years, of both sexes, may slightly increase the risk of occurrence of CP, especially with long-term use, warranting a caution regarding the onset of CP as a possible adverse effect of long-term statin use.

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Treatment Gap in the National Health-screening Program in Korea: Claim-based Follow-up of Statin Use for Sustained Hypercholesterolemia

Journal of Korean Medical Science ◽

10.3346/jkms.2015.30.9.1266 ◽

2015 ◽

Vol 30 (9) ◽

pp. 1266 ◽

Cited By ~ 10

Author(s):

Eunmi Ahn ◽

Dong Wook Shin ◽

Hyung-kook Yang ◽

Jae Moon Yun ◽

So Hyun Chun ◽

...

Keyword(s):

National Health ◽

Screening Program ◽

Health Screening ◽

Treatment Gap ◽

Health Screening Program ◽

Statin Use

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Association of nephrolithiasis with the risk of cardiovascular diseases: a longitudinal follow-up study using a national health screening cohort

BMJ Open ◽

10.1136/bmjopen-2020-040034 ◽

2020 ◽

Vol 10 (11) ◽

pp. e040034

Author(s):

So Young Kim ◽

Woo Jin Bang ◽

Chanyang Min ◽

Hyo Geun Choi

Keyword(s):

Heart Disease ◽

Ischaemic Heart Disease ◽

National Health ◽

Proportional Hazards Model ◽

Health Screening ◽

Cox Proportional Hazards Model ◽

Secondary Outcome ◽

Follow Up Study ◽

Age And Sex

ObjectivesThe aim of this study was to explore the associations of stroke and ischaemic heart disease in patients with nephrolithiasis.DesignA longitudinal follow-up study.SettingData from the Korean National Health Insurance Service–Health Screening Cohort (2002–2013) were retrieved to identify the occurrence of nephrolithiasis.Participants and interventionsIn total, 19 103 patients with nephrolithiasis were matched at a 1:4 ratio with control participants for age, sex, income and region of residence.Primary and secondary outcome measuresThe occurrence of stroke and ischaemic heart disease was analysed in both patients with nephrolithiasis and control participants. The primary outcome was HRs of stroke and ischaemic heart disease in a stratified Cox proportional hazards model. Smoking, alcohol consumption, obesity and Charlson Comorbidity Index were adjusted for as covariates. Subgroup analyses according to age and sex were also performed.ResultsEight per cent (1615/19 103) of patients with nephrolithiasis and 7.2% (5476/76 412) of control participants had stroke. Nine per cent (1879/19 103) of patients with nephrolithiasis and 7.7% (5895/76 412) of control participants had ischaemic heart disease. Patients with nephrolithiasis had risks of stroke and ischaemic heart disease that were 1.18 times (95% CI=1.11 to 1.24) and 1.24 times (95% CI=1.18 to 1.31) those of the control participants, respectively. The age and sex subgroups showed consistent results.ConclusionsNephrolithiasis was associated with increased risks of stroke and ischaemic heart disease.

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The Occurrence of Alzheimer’s Disease and Parkinson’s Disease in Individuals With Osteoporosis: A Longitudinal Follow-Up Study Using a National Health Screening Database in Korea

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.786337 ◽

2021 ◽

Vol 13 ◽

Author(s):

Mi Jung Kwon ◽

Joo-Hee Kim ◽

Ji Hee Kim ◽

Seong Jin Cho ◽

Eun Sook Nam ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Parkinson’S Disease ◽

Alzheimer's Disease ◽

Parkinson's Disease ◽

National Health ◽

Health Screening ◽

Incidence Rates ◽

Residential Area ◽

Follow Up Study

Background: Public health concerns regarding the potential link between osteoporosis and the increased occurrence of Alzheimer’s disease (AD) and Parkinson’s disease (PD) have been raised, but the results remain inconsistent and require further validation. Here, we investigated the long-term relationship of osteoporosis with the occurrence of AD/PD using data from a large-scale nationwide cohort.Methods: This longitudinal follow-up study included 78,994 patients with osteoporosis and 78,994 controls from the Korean National Health Insurance Service-Health Screening Cohort database (2002–2015) who were matched using propensity score matching at a 1:1 ratio based on age, sex, income, and residential area. A Cox proportional hazard model was used to assess the association between osteoporosis and the occurrence of AD/PD after adjusting for multiple covariates.Results: During the follow-up period, AD occurred in 5,856 patients with osteoporosis and 3,761 controls (incidence rates: 10.4 and 6.8 per 1,000 person-years, respectively), and PD occurred in 1,397 patients and 790 controls (incidence rates: 2.4 and 1.4 per 1,000 person-years, respectively). The incidences of AD and PD were significantly higher in the osteoporosis group than in the matched control group. After adjustment, the osteoporosis group exhibited 1.27-fold and 1.49-fold higher occurrences of AD (95% confidence interval (CI) = 1.22–1.32) and PD (95% CI = 1.36–1.63) than the controls, respectively. The results of subgroup analyses supported the increased occurrence of AD and PD in patients with osteoporosis, independent of income, residential area, obesity, smoking, alcohol consumption, hyperlipidemia, hypertension, or blood glucose level.Conclusion: Our results indicate that the presence of osteoporosis may increase the likelihood of developing two common neurodegenerative diseases in adults aged ≥40 years.

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Increased Risk of Migraine in Patients with Temporomandibular Disorder: A Longitudinal Follow-Up Study Using a National Health Screening Cohort

Diagnostics ◽

10.3390/diagnostics10090724 ◽

2020 ◽

Vol 10 (9) ◽

pp. 724

Author(s):

Soo-Hwan Byun ◽

Chanyang Min ◽

Dae-Myoung Yoo ◽

Byoung-Eun Yang ◽

Hyo-Geun Choi

Keyword(s):

Blood Pressure ◽

National Health ◽

Temporomandibular Disorder ◽

Fasting Blood Glucose ◽

Health Screening ◽

Control Group ◽

Follow Up Study ◽

Kaplan Meier ◽

Increased Risk

Background: The aim of this study was to investigate the association between temporomandibular disorder (TMD) and migraine through a longitudinal follow-up study using population data from a national health screening cohort. Methods: This cohort study used data from the Korean National Health Insurance Service-Health Screening Cohort from 2002 to 2015. Of the 514,866 participants, 3884 TMD patients were matched at a 1:4 ratio with 15,536 control participants. Crude models and models adjusted for obesity, smoking, alcohol consumption, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, and Charlson Comorbidity Index (CCI) scores were calculated. Chi-squared test, Kaplan–Meier analysis, and two-tailed log-rank test were used for statistical analysis. Stratified Cox proportional hazard models were used to assess hazard ratios (HR) and 95% confidence intervals (CIs) for migraine in both control groups. Results: The adjusted HR for migraine was 2.10 (95% CI: 1.81–2.44) in the TMD group compared to the control group, which was consistent in subgroup analyses according to age, sex, and Kaplan–Meier analysis. Conclusions: This study demonstrated that TMD patients have a higher risk of migraine. These results suggest that dentists can decrease the risk of migraine in TMD patients by managing TMD properly.

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Statin use increased new-onset diabetes in hypercholesterolemic individuals: Data from the Korean National Health Insurance Service-National Health Screening Cohort database (NHIS-HEALS)

Primary Care Diabetes ◽

10.1016/j.pcd.2019.08.005 ◽

2020 ◽

Vol 14 (3) ◽

pp. 246-253

Author(s):

Ye-Seul Kim ◽

Ye-Eun Han ◽

Eun-A Choi ◽

Na-Young You ◽

Jae-woo Lee ◽

...

Keyword(s):

Health Insurance ◽

National Health Insurance ◽

National Health ◽

Health Screening ◽

Onset Diabetes ◽

Korean National Health Insurance ◽

Statin Use ◽

New Onset

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Evaluation of the relationship between previous statin use and thyroid cancer using Korean National Health Insurance Service-Health Screening Cohort data

Scientific Reports ◽

10.1038/s41598-021-87297-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

So Young Kim ◽

Young Shin Song ◽

Jee Hye Wee ◽

Chanyang Min ◽

Dae Myoung Yoo ◽

...

Keyword(s):

Thyroid Cancer ◽

Health Insurance ◽

National Health Insurance ◽

National Health ◽

Conditional Logistic Regression ◽

Health Screening ◽

Cancer Group ◽

Korean National Health Insurance ◽

Adjusted Model ◽

Statin Use

AbstractThe association of thyroid cancer with statin use is controversial. This study aimed to investigate the association of previous statin use with thyroid cancer in the ≥ 40-year-old population in the Korean National Health Insurance Service-Health Screening Cohort. The 5501 patients in the thyroid cancer group were matched with the 22,004 patients in the non-thyroid cancer group for age, sex, income, and region of residence. Previous statin use during the 2 years before the diagnosis of thyroid cancer was examined. The odds ratios (ORs) with 95% confidence intervals (CIs) of previous statin use for thyroid cancer were estimated using conditional logistic regression analyses. Additionally, subgroup analyses were conducted. The thyroid cancer group showed more days of previous statin use than the non-thyroid cancer group (72.3, standard deviation [SD] = 181.2 days vs. 64.3, SD = 174.4 days, P = 0.003). Although the odds of previous statin use for thyroid cancer were high in the crude model (OR = 1.10, 95% CI 1.04–1.17, P = 0.002), they were low in the fully adjusted model (OR = 0.89, 95% CI 0.82–0.95, P = 0.001). According to age and sex subgroups, the younger (< 60 years old) male group showed lower odds for thyroid cancer according to previous statin use (adjusted OR = 0.70, 95% CI 0.55–0.88, P = 0.003), but this finding was not observed in other subgroups of older men or in any groups of women. Thyroid cancer was negatively associated with statin use in the previous 2 years in the adjusted model.

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