scholarly journals Quantitative Assessment of the T2 Relaxation Time of the Gluteus Muscles in Children with Duchenne Muscular Dystrophy: a Comparative Study Before and After Steroid Treatment

2010 ◽  
Vol 11 (3) ◽  
pp. 304 ◽  
Author(s):  
Hee Kyung Kim ◽  
Tal Laor ◽  
Paul S Horn ◽  
Brenda Wong
Neurology ◽  
2020 ◽  
Vol 95 (9) ◽  
pp. e1211-e1221 ◽  
Author(s):  
Julia R. Dahlqvist ◽  
Nanna S. Poulsen ◽  
Sofie T. Østergaard ◽  
Freja Fornander ◽  
Josefine de Stricker Borch ◽  
...  

ObjectiveWe followed up patients with facioscapulohumeral muscular dystrophy (FSHD) with sequential examinations over 2 years to investigate whether inflammatory lesions always precede fat replacement, if inflammation can be resolved without muscle degeneration, and if inflammatory lesions in muscle are always followed by fat replacement.MethodsIn this longitudinal study of 10 sequential MRI assessments over 2.5 years, we included 10 patients with FSHD. We used MRI with short TI inversion recovery to identify regions of interest (ROIs) with hyperintensities indicating muscle inflammation. Muscle T2 relaxation time mapping was used as a quantitative marker of muscle inflammation. Dixon sequences quantified muscle fat replacement. Ten healthy controls were examined with a magnetic resonance scan once for determination of normal values of T2 relaxation time.ResultsWe identified 68 ROIs with T2 elevation in the patients with FSHD. New ROIs with T2 elevation arising during the study had muscle fat content of 6.4% to 33.0% (n = 8) and 47.0% to 78.0% lesions that resolved (n = 6). ROIs with T2 elevation had a higher increase in muscle fat content from visits 1 to 10 (7.9 ± 7.9%) compared to ROIs with normal muscle T2 relaxation times (1.7 ± 2.6%; p < 0.0001). Severe T2 elevations were always followed by an accelerated replacement of muscle by fat.ConclusionsOur results suggest that muscle inflammation starts in mildly affected muscles in FSHD, is related to a faster muscle degradation, and continues until the muscles are completely fat replaced.ClinicalTrials.gov identifierNCT02159612.


2002 ◽  
Vol 30 (3) ◽  
pp. 374-381 ◽  
Author(s):  
Yoshitsugu Takeda ◽  
Shinji Kashiwaguchi ◽  
Kenji Endo ◽  
Tetsuya Matsuura ◽  
Takahiro Sasa

Background Electromyography has been used to determine the best exercise for strengthening the supraspinatus muscle, but conflicting results have been reported. Magnetic resonance imaging T2 relaxation time appears to be more accurate in determining muscle activation. Purpose To determine the best exercises for strengthening the supraspinatus muscle. Study Design Criterion standard. Methods Six male volunteers performed three exercises: the empty can, the full can, and horizontal abduction. Immediately before and after each exercise, magnetic resonance imaging examinations were performed and changes in relaxation time for the subscapularis, supraspinatus, infraspinatus, teres minor, and deltoid muscles were recorded. Results The supraspinatus muscle had the greatest change among the studied muscles in relaxation time for the empty can (10.5 ms) and full can (10.5 ms) exercises. After the horizontal abduction exercise the change in relaxation time for the supraspinatus muscle (3.6 ms) was significantly smaller than that for the posterior deltoid muscle (11.5 ms) and not significantly different from that of the other muscles studied. Conclusion The empty can and full can exercises were most effective in activating the supraspinatus muscle.


2020 ◽  
Author(s):  
Chih-Chien Tsai ◽  
Shu-Hang Ng ◽  
Yao-Liang Chen ◽  
Yu-Hsiang Juan ◽  
Chao-Hung Wang ◽  
...  

Radiology ◽  
2004 ◽  
Vol 232 (2) ◽  
pp. 592-598 ◽  
Author(s):  
Timothy C. Dunn ◽  
Ying Lu ◽  
Hua Jin ◽  
Michael D. Ries ◽  
Sharmila Majumdar

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