scholarly journals Apelin-13 Regulates Vasopressin-Induced Aquaporin-2 Expression and Trafficking in Kidney Collecting Duct Cells

2019 ◽  
Vol 53 (4) ◽  
pp. 687-700 ◽  
Keyword(s):  
Collecting Duct ◽  
Kidney Collecting Duct ◽  
Aquaporin 2 ◽  
Duct Cells ◽  
Collecting Duct Cells

scholarly journals Transcription Factor Elf3 Modulates Vasopressin-Induced Aquaporin-2 Gene Expression in Kidney Collecting Duct Cells

2019 ◽  
Vol 10 ◽  
Author(s):  
Shu-Ting Lin ◽  
Chia-Ching Ma ◽  
Kuang-Ting Kuo ◽  
Yin-Fang Su ◽  
Wei-Ling Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Collecting Duct ◽  
Kidney Collecting Duct ◽  
Aquaporin 2 ◽  
Duct Cells ◽  
Collecting Duct Cells

scholarly journals Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Water Channel Aquaporin-2 of Kidney Collecting Duct Cells

2004 ◽  
Vol 96 (3) ◽  
pp. 255-259 ◽  
Author(s):  
Kuniaki Takata ◽  
Yuki Tajika ◽  
Toshiyuki Matsuzaki ◽  
Takeo Aoki ◽  
Takeshi Suzuki ◽  
...  
Keyword(s):  
Drug Development ◽  
Molecular Mechanisms ◽  
Collecting Duct ◽  
Water Channel ◽  
Kidney Collecting Duct ◽  
Aquaporin 2 ◽  
Duct Cells ◽  
Collecting Duct Cells ◽  
Aquaporin Water Channel

scholarly journals A Minireview on Vasopressin-regulated Aquaporin-2 in Kidney Collecting Duct Cells

2015 ◽  
Vol 13 (1) ◽  
pp. 1 ◽  
Author(s):  
Eui-Jung Park ◽  
Tae-Hwan Kwon
Keyword(s):  
Collecting Duct ◽  
Kidney Collecting Duct ◽  
Aquaporin 2 ◽  
Duct Cells ◽  
Collecting Duct Cells

scholarly journals PKCα regulates vasopressin-induced aquaporin-2 trafficking in mouse kidney collecting duct cells in vitro via altering microtubule assembly

2012 ◽  
Vol 33 (2) ◽  
pp. 230-236 ◽  
Author(s):  
Hong Zhao ◽  
Xi Yao ◽  
Tao-xia Wang ◽  
Wen-min Jin ◽  
Qian-qian Ji ◽  
...  
Keyword(s):  
Collecting Duct ◽  
Mouse Kidney ◽  
Microtubule Assembly ◽  
Kidney Collecting Duct ◽  
Aquaporin 2 ◽  
Duct Cells ◽  
Collecting Duct Cells

scholarly journals FP027VASOPRESSIN-REGULATED MICRORNAS AND AQUAPORIN-2-TARGETING MICRORNAS IN KIDNEY COLLECTING DUCT CELLS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii74-iii74
Author(s):  
Tae-Hwan Kwon ◽  
Jae-Eun Kim ◽  
Hyun Jun Jung ◽  
Yu-Jung Lee
Keyword(s):  
Collecting Duct ◽  
Kidney Collecting Duct ◽  
Aquaporin 2 ◽  
Duct Cells ◽  
Collecting Duct Cells

MAGED2 controls vasopressin-induced aquaporin-2 expression in collecting duct cells

2021 ◽  
pp. 104424
Author(s):  
Björn Reusch ◽  
Malte P. Bartram ◽  
Claudia Dafinger ◽  
Nicolàs Palacio-Escat ◽  
Andrea Wenzel ◽  
...  
Keyword(s):  
Collecting Duct ◽  
Aquaporin 2 ◽  
Duct Cells ◽  
Collecting Duct Cells

scholarly journals Lixivaptan, a New Generation Diuretic, Counteracts Vasopressin-Induced Aquaporin-2 Trafficking and Function in Renal Collecting Duct Cells

2019 ◽  
Vol 21 (1) ◽  
pp. 183
Author(s):  
Annarita Di Mise ◽  
Maria Venneri ◽  
Marianna Ranieri ◽  
Mariangela Centrone ◽  
Lorenzo Pellegrini ◽  
...  
Keyword(s):  
Collecting Duct ◽  
Water Channel ◽  
Plasma Osmolality ◽  
Kinetic Measurements ◽  
Aquaporin 2 ◽  
Plasma Vasopressin ◽  
Duct Cells ◽  
Collecting Duct Cells ◽  
Renal Collecting Duct ◽  
New Generation

Vasopressin V2 receptor (V2R) antagonists (vaptans) are a new generation of diuretics. Compared with classical diuretics, vaptans promote the excretion of retained body water in disorders in which plasma vasopressin concentrations are inappropriately high for any given plasma osmolality. Under these conditions, an aquaretic drug would be preferable over a conventional diuretic. The clinical efficacy of vaptans is in principle due to impaired vasopressin-regulated water reabsorption via the water channel aquaporin-2 (AQP2). Here, the effect of lixivaptan—a novel selective V2R antagonist—on the vasopressin-cAMP/PKA signaling cascade was investigated in mouse renal collecting duct cells expressing AQP2 (MCD4) and the human V2R. Compared to tolvaptan—a selective V2R antagonist indicated for the treatment of clinically significant hypervolemic and euvolemic hyponatremia—lixivaptan has been predicted to be less likely to cause liver injury. In MCD4 cells, clinically relevant concentrations of lixivaptan (100 nM for 1 h) prevented dDAVP-induced increase of cytosolic cAMP levels and AQP2 phosphorylation at ser-256. Consistent with this finding, real-time fluorescence kinetic measurements demonstrated that lixivaptan prevented dDAVP-induced increase in osmotic water permeability. These data represent the first detailed demonstration of the central role of AQP2 blockade in the aquaretic effect of lixivaptan and suggest that lixivaptan has the potential to become a safe and effective therapy for the treatment of disorders characterized by high plasma vasopressin concentrations and water retention.

Adaptation to alkalosis induces cell cycle delay and apoptosis in cortical collecting duct cells: Role of aquaporin-2

2010 ◽  
Vol 224 (2) ◽  
pp. 405-413 ◽  
Author(s):  
Valeria Rivarola ◽  
Pilar Flamenco ◽  
Luciana Melamud ◽  
Luciano Galizia ◽  
Paula Ford ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Collecting Duct ◽  
Cortical Collecting Duct ◽  
Cell Cycle Delay ◽  
Aquaporin 2 ◽  
Duct Cells ◽  
Collecting Duct Cells

scholarly journals A Role for VAMP8/Endobrevin in Surface Deployment of the Water Channel Aquaporin 2

2009 ◽  
Vol 30 (1) ◽  
pp. 333-343 ◽  
Author(s):  
Cheng-Chun Wang ◽  
Chee Peng Ng ◽  
Hong Shi ◽  
Hwee Chien Liew ◽  
Ke Guo ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Membrane Protein ◽  
Collecting Duct ◽  
Water Channel ◽  
Snare Proteins ◽  
Snare Protein ◽  
Aquaporin 2 ◽  
Duct Cells ◽  
Collecting Duct Cells ◽  
Intracellular Vesicles

ABSTRACT Vesicle-associated-membrane protein 8 (VAMP8) is highly expressed in the kidney, but the exact physiological and molecular functions executed by this v-SNARE protein in nephrons remain elusive. Here, we show that the depletion of VAMP8 in mice resulted in hydronephrosis. Furthermore, the level of the vasopressin-responsive water channel aquaporin 2 (AQP2) was increased by three- to fivefold in VAMP8-null mice. Forskolin and [desamino-Cys1, D-Arg8]-vasopressin (DDAVP)-induced AQP2 exocytosis was impaired in VAMP8-null collecting duct cells. VAMP8 was revealed to colocalize with AQP2 on intracellular vesicles and to interact with the plasma membrane t-SNARE proteins syntaxin4 and syntaxin3, suggesting that VAMP8 mediates the regulated fusion of AQP2-positive vesicles with the plasma membrane.

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