Role of tissue molecular pathogens in development of acute chronic liver failure in alcoholic liver cirrhosis

2021 ◽  
pp. 19-22
Author(s):  
O. P. Dudanova ◽  
M. E. Shubina ◽  
A. S. Rodina ◽  
I. V. Kurbatova ◽  
L. V. Topchieva

The aim of the study was to assess the pathogenetic, diagnostic and clinical role of tissue molecular pathogens – fragments of cytokeratin-18 in the development of acute chronic liver failure (ACLF) in decompensated alcoholic liver cirrhosis (ALC).Materials and methods. 80 patients with ALC were examined: 30 without signs of ACLF and 50 with signs of ACLF and 36 healthy individuals. Hepatic functional tests were determined, a marker of hepatocyte apoptosis – fragments of cytokeratin-18 (FCK-18) (Biotech, Sweden) by the enzyme immunoassay, ACLF scores were calculated using an on-line calculator at www.efclif.com/scientific-activity/score-calculators/ clif-c-aclf.Results. With ACLF, a high level of FCK-18 was detected – 1505.4 ± 446.9 U/L, more than 20 times higher than that in healthy individuals – 71.5 ± 19.6 U/L (p < 0.05) and three times higher than the level of FCK-18 in patients with ALC without ACLF – 489.4 ± 490.2 U/L. The levels of aminotransferases, bilirubin, creatinine, INR were significantly higher in patients with ACLF compared with patients without ACLF, and the level of albumin was lower. FCK-18 level directly correlated with ALT – r = 0.61 (p < 0.05), AST – r = 0.68 (p < 0.05), with bilirubin level – r = 0.41 (p < 0, 05) and the ACLF score – r = 0.48 (p < 0.05) and inversely correlated with the albumin level r = –0.51 (p < 0.05).Conclusion. Apoptosis of hepatocytes and tissue molecular pathogens released during it – fragments of cytokeratin-18 – play a role in the development of acute chronic liver failure in decompensated alcoholic liver cirrhosis.

2016 ◽  
Vol 6 ◽  
pp. S7
Author(s):  
Swapnil Dhampalwar ◽  
Aamritangsu Borkakoty ◽  
Sunil Taneja ◽  
Ajay Duseja ◽  
Radha K. Dhiman ◽  
...  

2019 ◽  
Vol 70 (6) ◽  
pp. 1301-1302
Author(s):  
Ruben Hernaez ◽  
Jennifer R. Kramer ◽  
Yan Liu ◽  
Fasiha Kanwal

2015 ◽  
Vol 5 (4) ◽  
pp. 303-309 ◽  
Author(s):  
Praveen Sharma ◽  
Rinkesh Bansal ◽  
Abdul Matin ◽  
Pankaj Tyagi ◽  
Naresh Bansal ◽  
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2020 ◽  
Vol 73 ◽  
pp. S504
Author(s):  
Tammo Lambert Tergast ◽  
Abdul-Rahman Kabbani ◽  
Marie Schultalbers ◽  
Michael P. Manns ◽  
Markus Cornberg ◽  
...  

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