Early Criteria for the Diagnosis of Optic Neuritis in the Setting of Davic’s Disease

The Eye ◽  
2021 ◽  
Vol 23 (2) ◽  
pp. 33-39
Author(s):  
Kh. M. Kamilov ◽  
M. S. Kasimova ◽  
G. Kh. Khamraeva

Background. Optic neuritis is the first symptom of Davic’s disease in more than half of cases. Differential diagnosis of optic neuritis in the clinical practice is complicated due to the uniformity of the clinical pattern of inflammatory and demyelinating optic neuritis in the early stages of the disease. The approach to the management of patients with Davic’s disease is varied and requires a precise differentiation at the initial stages of its development.Purpose. To determine early objective criteria for diagnosing the optic neuritis in the setting of Davic’s disease.Materials and methods. We observed 31 patients (51 eyes), while the control group consisted of 12 healthy individuals (12 eyes). Research methods were both standard ophthalmic and specialized – optical coherence tomography, visual evoked potential test, magnetic resonance imaging of the brain and spinal cord.Results. In patients with optic neuritis in the setting of Davic’s disease, optical coherence tomography revealed a smaller area of the optic nerve disc and neuroretinal belt as well as a decrease in macular volume and macular thickness. A reduction of the retinal ganglion cell complex and the inner plexiform layer was also revealed.Conclusion. At the initial stages of Davic’s disease, it is necessary to conduct optical coherence tomography of the retina, perform visual evoked potential test as well as magnetic resonance imaging of the brain and spinal cord. Appropriate treatment at an early stage of the disease can reduce the rates of axonal degeneration and optic disc atrophy development.

1986 ◽  
Vol 104 (10) ◽  
pp. 1486-1488 ◽  
Author(s):  
K. Johns ◽  
P. Lavin ◽  
J. H. Elliot ◽  
C. L. Partain

2012 ◽  
Vol 37 (5) ◽  
pp. 872 ◽  
Author(s):  
Jason M. Tucker-Schwartz ◽  
Tu Hong ◽  
Daniel C. Colvin ◽  
Yaqiong Xu ◽  
Melissa C. Skala

2013 ◽  
Vol 71 (9B) ◽  
pp. 714-716 ◽  
Author(s):  
Otavio Augusto Moreno de Carvalho

Mansonic neuroschistosomiasis (MN) is not only the most common but also the most serious ectopic presentation of the infection by Schistosoma mansoni. Both, brain and spinal cord can be independently affected by the infection, but the later is more frequently affected. Brain MN by itself is due to the presence of eggs and/or adult worms in situ and can be symptomatic or asymptomatic. Unlike the brain MN, spinal cord mansonic neuroschistosomiasis is more frequently symptomatic. In both forms the intensity, the seriousness and also the clinical characteristics of signs and symptoms depend on the amount of eggs in the compromised region and on the intensity of the inflammatory reaction surrounding the eggs. Cerebrospinal fluid examination and magnetic resonance imaging are important diagnostic tools. Both corticosteroids and drugs against S. mansoni are used in the treatment. The outcome may largely depend upon the prompt use of these drugs.


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