EPIDIDYMOORCHITIS AS AN EXTRAINTESTINAL MANIFESTATION OF CROHN’S DISEASE (case report)

Extraintestinal manifestations are found at least in a quarter of patients with Crohn's disease. In contrast to eyes lesions, joints and skin, epididymoorchitis caused by Crohn's disease is extremely rare and is described in few papers. However, orchitis and epididymitis are described in another autoimmune disease, ankylosing spondylitis and, although the incidence of asymptomatic orchitis in ankylosing spondylitis is unknown, it is often diagnosed during examinations for male infertility. A clinical case report of a 26-year-old patient suffering from Crohn's disease with extraintestinal manifestations in the form of orchiepididymitis is presented. While receiving treatment in the urological unit, the patient underwent several procedures, including a right-side orchiectomy, but the inflammatory process progressed with the risk of losing the only remaining testicle. Only after ileocecal resection for the penetrating Crohn's disease with ileosigmoid fistula and following biological therapy, it was possible to achieve remission and preserve a single testicle.

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EPIDIDYMOORCHITIS AS AN EXTRAINTESTINAL MANIFESTATION OF CROHN’S DISEASE (case report)

Koloproktologia ◽

10.33878/2073-7556-2019-18-3(69)-104 ◽

2019 ◽

Vol 18 (3(69)) ◽

pp. 104

Author(s):

D. A. Khubezov ◽

S. N. Trushin ◽

A. Y. Ogoreltsev ◽

E. I. Semionkin

Keyword(s):

Crohn’S Disease ◽

Case Report ◽

Crohn's Disease ◽

Extraintestinal Manifestation ◽

Disease Case

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Immune Thrombocytopenic Purpura (ITP) as an Uncommon Extraintestinal Complication of Crohn’s Disease: Case Vignette and Systematic Literature Review

Case Reports in Hematology ◽

10.1155/2020/4785759 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Raisa Epistola ◽

Tiffanie Do ◽

Ritika Vankina ◽

Daniel Wu ◽

James Yeh ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Immune Thrombocytopenic Purpura ◽

Case Reports ◽

Case Vignette ◽

Mucosal Permeability ◽

Extraintestinal Manifestation ◽

Thrombocytopenic Purpura ◽

Disease Case ◽

Inflammatory Bowel

While the association of immune thrombocytopenic purpura (ITP) and inflammatory bowel disease (IBD) has been described in a few case reports, management of ITP as an extraintestinal manifestation of Crohn’s disease (CD) is less studied. There are approximately a dozen cases describing the management of patients dually diagnosed with CD/ITP. Previous reports postulated that the mechanism of ITP in CD was through the presence of circulating immune complexes in the serum and antigenic mimicry due to increased mucosal permeability in active colitis, versus increased mucosal production of TH1-type proinflammatory cytokines during CD flares, which may account for remission of ITP with surgery for CD. We present a case of a 27-year-old man who presented with medically refractory CD and ITP who responded to surgical management with colectomy and splenectomy, along with a systematic review of the literature. These cases suggest that colectomy should be considered in the treatment of medically refractory ITP among patients with concomitant CD.

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