scholarly journals Immune Thrombocytopenic Purpura (ITP) as an Uncommon Extraintestinal Complication of Crohn’s Disease: Case Vignette and Systematic Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Raisa Epistola ◽  
Tiffanie Do ◽  
Ritika Vankina ◽  
Daniel Wu ◽  
James Yeh ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Immune Thrombocytopenic Purpura ◽  
Case Reports ◽  
Case Vignette ◽  
Mucosal Permeability ◽  
Extraintestinal Manifestation ◽  
Thrombocytopenic Purpura ◽  
Disease Case ◽  
Inflammatory Bowel

While the association of immune thrombocytopenic purpura (ITP) and inflammatory bowel disease (IBD) has been described in a few case reports, management of ITP as an extraintestinal manifestation of Crohn’s disease (CD) is less studied. There are approximately a dozen cases describing the management of patients dually diagnosed with CD/ITP. Previous reports postulated that the mechanism of ITP in CD was through the presence of circulating immune complexes in the serum and antigenic mimicry due to increased mucosal permeability in active colitis, versus increased mucosal production of TH1-type proinflammatory cytokines during CD flares, which may account for remission of ITP with surgery for CD. We present a case of a 27-year-old man who presented with medically refractory CD and ITP who responded to surgical management with colectomy and splenectomy, along with a systematic review of the literature. These cases suggest that colectomy should be considered in the treatment of medically refractory ITP among patients with concomitant CD.

scholarly journals A Rare Case of Gastric Crohn’s Disease Complicated by Gastric Carcinoma

2018 ◽  
pp. 1-6
Author(s):  
Marwah Sami M Hussain ◽  
Bandar Idrees Ali ◽  
Abdullah Alzahrani
Keyword(s):  
Gastric Cancer ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Bowel Diseases ◽  
Rare Case ◽  
Small Bowel Adenocarcinoma ◽  
Disease Case ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Upper Gastrointestinal

Background: Inflammatory bowel diseases are strongly associated with colorectal cancer. In addition, a few cases reported with gastric and small bowel adenocarcinoma in gastroduodenal Crohn’s disease. Case report: We reported a case of a 47-Year-old female, who was referred to our surgical department and after a routine gastroscopy which revealed a lesion. Biopsy confirmed gastric well-differentiated adenocarcinoma of limited gastric Crohn’s disease, for a patient on regular anti Crohn’s medication. The patient underwent varying laparoscopic distal gastrectomy. She received adjuvant chemotherapy treatment and thereafter, she was cancer free within the period of 3- years of regular follow up. Conclusion: The only way to diagnose such lesions of a rare case of gastric cancer in a patient with Crohn’s disease is to regularly carry out upper gastrointestinal examinations. Keywords: Inflammatory bowel diseases, Crohn’s disease, Upper gastrointestinal tract Crohn’s disease, Gastric cancer

Interesting case of dual pathology: Crohn’s disease and Peutz-Jeghers syndrome

2020 ◽  
Vol 13 (10) ◽  
pp. e234513
Author(s):  
Mantej Sehmbhi ◽  
Penelope Sellers ◽  
Jonathan Segal ◽  
Susan Clark
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Case Reports ◽  
Interesting Case ◽  
Night Sweats ◽  
History Of ◽  
Progressive Weight Loss ◽  
Inflammatory Bowel ◽  
Peutz Jeghers Syndrome ◽  
The Uk

An 18-year-old man presented with fever, night sweats and progressive weight loss over 2 months. He had a history of Peutz-Jeghers syndrome (PJS) complicated by previous intussusception requiring left hemicolectomy. Colonoscopy revealed deep punched out ulceration throughout the colon with multiple polyps. He was investigated for tuberculosis based on his occupation as dairy farmer. Following a negative QuantiFERON test, he was started on infliximab as emergency therapy and made a good recovery at 6 months follow-up. We describe a case of newly diagnosed Crohn’s disease (CD) in an adolescent with a background diagnosis of PJS. While inflammatory bowel disease, such as CD, is common in the UK, the association with PJS is very rare, with only two existing case reports in the literature.

scholarly journals Case Report: Refractory Chronic Spontaneous Urticaria Treated With Omalizumab in an Adolescent With Crohn’s Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Simona Barni ◽  
Mattia Giovannini ◽  
Giulia Liccioli ◽  
Lucrezia Sarti ◽  
Anna Gissi ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Case Reports ◽  
Chronic Spontaneous Urticaria ◽  
Tumor Necrosis Factors ◽  
T Helper 2 ◽  
Tnf Α ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
The Moment

Chronic spontaneous urticaria (CSU) is a mast cell-driven disease that is often associated with autoimmune or autoinflammatory conditions. Omalizumab is recommended in the treatment of refractory CSU in patients over 12 years of age who do not respond to four standard doses of antihistamines. Omalizumab blocks the mast cells’ degranulation, thus interrupting the resulting inflammatory cascade driven by T-helper 2 (Th2) cytokines. The efficacy of omalizumab in controlling CSU and possible associated diseases has been studied in few patients so far. In particular, some case reports describe adults with CSU and concomitant inflammatory bowel diseases (IBD), such as Crohn’s disease (CD) or ulcerative colitis (UC). Although the treatment of CD with anti-tumor necrosis factors-α (TNF-α) seems to be effective in controlling CSU, no cases of the utility of omalizumab in patients with both conditions have been described so far. At the moment, there is no evidence that the pathogenetic mechanisms underlying CD are linked to the same pathways that are inhibited by omalizumab for the treatment of CSU. We present the first pediatric case of refractory CSU and CD in which omalizumab led to CSU remission, even if the follow-up period was limited. In conclusion, our experience shows how CSU could be associated with CD and successfully treated with the monoclonal anti-IgE antibody in a patient on immunosuppressive therapy. However, more data is needed from a larger population.

scholarly journals Granulomatous vulvitis and Gullain-Barre syndrome in pediatric Crohn’s disease: a case report

2021 ◽  
Vol 8 (6) ◽  
pp. 1121
Author(s):  
Pujitha Bandla ◽  
Bhakti Sarangi ◽  
Guruprasad H. Shankar ◽  
Varsha Sharma
Keyword(s):  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Gastrointestinal Symptoms ◽  
Granulomatous Inflammation ◽  
Extraintestinal Manifestation ◽  
Gastrointestinal Manifestations ◽  
Inflammatory Bowel

Granulomatous vulvitis/cheilitis may occur rarely as an extraintestinal manifestation of Crohn’s disease (CD) and may precede the development of gastrointestinal symptoms. Guillain-Barre syndrome (GBS) is associated with a wide variety of illnesses including inflammatory bowel disease. Though the immunologic abnormalities in inflammatory bowel disease may encompass both granulomatous inflammation as well as autoimmune components, the combination of CD, GBS and granulomatous vulvitis/cheilitis in the same patient has not been described in literature. We hereby reported a 14 year old girl with granulomatous vulvitis/cheilitis for 4 years preceding the development of gastrointestinal manifestations of CD, who also had GBS during the course of hospitalization.

scholarly journals Myopericarditis as an Extra-Intestinal Manifestation of Crohn’s Disease: A Case Report

2022 ◽  
Vol 5 (1) ◽  
pp. 01-05
Author(s):  
Rohan Prasad ◽  
Surya Chennupati ◽  
Tyler Kemnic ◽  
Abdullah Al-abcha ◽  
Manel Boumegouas ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Case Reports ◽  
Case Presentation ◽  
Reactive Protein ◽  
History Of ◽  
St Elevation ◽  
Inflammatory Bowel ◽  
Small Pericardial Effusion

Introduction: Myopericarditis is an uncommon manifestation of Crohn’s disease. Interestingly enough, it can present in a patient without any acute bowel symptoms. Case Presentation: A 21-year-old male with a medical history of Crohn’s disease and eosinophilic esophagitis presented to the hospital with chest pain and fever. Blood work revealed elevated troponin, C-reactive protein, and sedimentation rate levels. Electrocardiogram (EKG) showed diffuse ST elevation in all leads. Transthoracic echocardiogram (TTE) demonstrated a small pericardial effusion without valvular abnormalities. The patient was diagnosed with myopericarditis. Extensive etiological workup was negative, in the absence of other explanations, it was attributed to his Crohn’s disease. The patient was started on colchicine and ibuprofen. Out-patient follow-up revealed resolution of symptoms. Conclusion: This case reports the rare occurrence of myopericarditis and Crohn’s disease. Inflammatory bowel disease as a cause of myopericarditis has been reported in some cases within the literature; however, there is no definitive mechanism known.

scholarly journals EPIDIDYMOORCHITIS AS AN EXTRAINTESTINAL MANIFESTATION OF CROHN’S DISEASE (case report)

2019 ◽  
Vol 18 (3(69)) ◽  
pp. 99-103
Author(s):  
D. A. Khubezov ◽  
S. N. Trushin ◽  
A. Y. Ogoreltsev ◽  
E. I. Semionkin
Keyword(s):  
Crohn’S Disease ◽  
Case Report ◽  
Ankylosing Spondylitis ◽  
Crohn's Disease ◽  
Biological Therapy ◽  
Ileocecal Resection ◽  
Extraintestinal Manifestations ◽  
Extraintestinal Manifestation ◽  
Disease Case ◽  
Penetrating Crohn’S Disease

Extraintestinal manifestations are found at least in a quarter of patients with Crohn's disease. In contrast to eyes lesions, joints and skin, epididymoorchitis caused by Crohn's disease is extremely rare and is described in few papers. However, orchitis and epididymitis are described in another autoimmune disease, ankylosing spondylitis and, although the incidence of asymptomatic orchitis in ankylosing spondylitis is unknown, it is often diagnosed during examinations for male infertility. A clinical case report of a 26-year-old patient suffering from Crohn's disease with extraintestinal manifestations in the form of orchiepididymitis is presented. While receiving treatment in the urological unit, the patient underwent several procedures, including a right-side orchiectomy, but the inflammatory process progressed with the risk of losing the only remaining testicle. Only after ileocecal resection for the penetrating Crohn's disease with ileosigmoid fistula and following biological therapy, it was possible to achieve remission and preserve a single testicle.

scholarly journals Genital and Intertriginous Rashes Refractory to Antimicrobial Treatments: Have You Thought about Crohn’s Disease?

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Candelaria O’Farrell ◽  
Annette Roberts ◽  
Claudia Riera Canales ◽  
Carrie Firestone Baum ◽  
Lina Maria Felipez
Keyword(s):  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Gastrointestinal Symptoms ◽  
Extraintestinal Manifestations ◽  
Extraintestinal Manifestation ◽  
Tract Involvement ◽  
Inflammatory Bowel ◽  
Antimicrobial Treatments ◽  
Bloody Stools

Crohn’s disease is an inflammatory bowel disease that can have multiple extraintestinal manifestations and can develop prior to, following, or simultaneously with gastrointestinal tract involvement (Aberumand et al. (2017), Georgious et al. (2006), Larsen et al. (2010), Levine and Burakoff (2011), Louis et al. (2018)). This report examines the case of a 16-year-old male with a rash of the genital, intergluteal, and inguinal regions refractory to antimicrobial treatments suspicious for an extraintestinal manifestation of Crohn’s disease. The patient was diagnosed with inflammatory, nonfistulizing colonic Crohn’s disease following presentation with gastrointestinal symptoms including abdominal pain and bloody stools 6 months after the onset of the rash. The genital lesions resolved after starting treatment for Crohn’s disease with adalimumab.

scholarly journals Keeping an Eye on Crohn’s Disease: Orbital Myositis as the Presenting Symptom

1997 ◽  
Vol 11 (6) ◽  
pp. 497-500 ◽  
Author(s):  
Carol A Durno ◽  
Robert Ehrlich ◽  
Robert Taylor ◽  
J Raymond Buncic ◽  
Peter Hughes ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intestinal Inflammation ◽  
Extraintestinal Manifestation ◽  
Orbital Myositis ◽  
Thyroid Orbitopathy ◽  
Rare Manifestation ◽  
History Of ◽  
Appropriate Therapy ◽  
Inflammatory Bowel

Episodic periorbital swelling due to presumed orbital inflammation and myositis caused intermittent apparent proptosis and was the presenting symptom of ileocecal Crohn's disease (CD) in a teenage female with a family history of autoimmune disorders and CD. Orbital myositis, a very rare extraintestinal manifestation of inflammatory bowel disease (IBD), likely represents a process of impaired immunoregulation related to the underlying intestinal inflammation. This rare manifestation of IBD simulates the more commonly encountered thyroid orbitopathy (ophthalmopathy), but IBD should be considered if all thyroid tests are negative. It is important to recognize that orbital myositis may be an extraintestinal manifestation of Crohn's disease so that the diagnosis can be made and appropriate therapy commenced.

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