Use of 3D Models in Drug Development and Precision Medicine: Advances and Outlook

2021 ◽  
Keyword(s):  
Drug Development ◽  
Precision Medicine ◽  
3D Models

scholarly journals Editorial: Use of 3D Models in Drug Development and Precision Medicine - Advances and Outlook

2021 ◽  
Vol 9 ◽  
Author(s):  
Adriele Prina-Mello ◽  
Luigi Bonacina ◽  
Davide Staedler ◽  
Dania Movia
Keyword(s):  
Drug Development ◽  
Precision Medicine ◽  
3D Models

Prevascularized, Co-Culture Model for Breast Cancer Drug Development

2012 ◽  
Author(s):  
Lauren Marshall ◽  
Isabel Löwstedt ◽  
Paul Gatenholm ◽  
Joel Berry
Keyword(s):  
Breast Cancer ◽  
Drug Development ◽  
Three Dimensional ◽  
Human Tumor ◽  
3D Models ◽  
Cancer Drug ◽  
Cancer Therapies ◽  
Anti Cancer

The objective of this study was to create 3D engineered tissue models to accelerate identification of safe and efficacious breast cancer drug therapies. It is expected that this platform will dramatically reduce the time and costs associated with development and regulatory approval of anti-cancer therapies, currently a multi-billion dollar endeavor [1]. Existing two-dimensional (2D) in vitro and in vivo animal studies required for identification of effective cancer therapies account for much of the high costs of anti-cancer medications and health insurance premiums borne by patients, many of whom cannot afford it. An emerging paradigm in pharmaceutical drug development is the use of three-dimensional (3D) cell/biomaterial models that will accurately screen novel therapeutic compounds, repurpose existing compounds and terminate ineffective ones. In particular, identification of effective chemotherapies for breast cancer are anticipated to occur more quickly in 3D in vitro models than 2D in vitro environments and in vivo animal models, neither of which accurately mimic natural human tumor environments [2]. Moreover, these 3D models can be multi-cellular and designed with extracellular matrix (ECM) function and mechanical properties similar to that of natural in vivo cancer environments [3].

Modeling human carcinomas: Physiologically relevant 3D models to improve anti-cancer drug development

2014 ◽  
Vol 79-80 ◽  
pp. 50-67 ◽  
Author(s):  
Christine Unger ◽  
Nina Kramer ◽  
Angelika Walzl ◽  
Martin Scherzer ◽  
Markus Hengstschläger ◽  
...  
Keyword(s):  
Drug Development ◽  
3D Models ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Human Carcinomas

scholarly journals New Year, New Name and New Milestones Scope — Journal of Circulating Biomarkers

2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Shidong Jia ◽  
Winston Patrick Kuo
Keyword(s):  
Drug Development ◽  
Precision Medicine ◽  
Tumor Cells ◽  
Circulating Dna ◽  
International Level ◽  
Protein Markers ◽  
Circulating Biomarkers ◽  
Free Circulating Dna ◽  
American Society

This editorial article introduces a renaming of journal Exosomes and Microvesicles (EXMV) to the Journal of Circulating Biomarkers with a new editorial scope, mission and our approach for the upcoming year in relation to engaging at the international level, the translational art of the study of exosomes and microvesicles, and the interface between exosomes and microvesicles, circulating tumor cells, cell-free circulating DNA and circulating protein markers in precision medicine and drug development. There is a slight change in the members of the Editors in Chief, Editorial Board and extending collaborations to international societies, such as the American Society for Exosomes and Microvesicles (ASEMV).

Precision Medicine: The Function of Receptor Occupancy in Drug Development

2020 ◽  
pp. 167-197
Author(s):  
Leanne Flye-Blakemore ◽  
Christèle Gonneau ◽  
Nithianandan Selliah ◽  
Ajay Grover ◽  
Sriram Ramanan ◽  
...  
Keyword(s):  
Drug Development ◽  
Precision Medicine ◽  
Receptor Occupancy

scholarly journals Predictive biomarkers in precision medicine and drug development against lung cancer

2015 ◽  
Vol 34 (3) ◽  
Author(s):  
Bingliang Fang ◽  
Reza J Mehran ◽  
John V Heymach ◽  
Stephen G Swisher
Keyword(s):  
Lung Cancer ◽  
Drug Development ◽  
Precision Medicine ◽  
Predictive Biomarkers

Human biomimetic liver microphysiology systems in drug development and precision medicine

2020 ◽  
Author(s):  
Albert Gough ◽  
Alejandro Soto-Gutierrez ◽  
Lawrence Vernetti ◽  
Mo R. Ebrahimkhani ◽  
Andrew M. Stern ◽  
...  
Keyword(s):  
Drug Development ◽  
Precision Medicine

scholarly journals Use of big data in drug development for precision medicine

2016 ◽  
Vol 1 (3) ◽  
pp. 245-253 ◽  
Author(s):  
Rosa S. Kim ◽  
Nicolas Goossens ◽  
Yujin Hoshida
Keyword(s):  
Big Data ◽  
Drug Development ◽  
Precision Medicine
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