scholarly journals The impact of polymorphisms in the host immune response genes on the severity of chronic hepatitis C

2013 ◽  
Vol 4 ◽  
Author(s):  
Su Hoang ◽  
Thelu Marie-Ange ◽  
Leroy Vincent ◽  
Zarski Jean ◽  
Marlu Alice ◽  
...  
Keyword(s):  
Immune Response ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Host Immune Response ◽  
Immune Response Genes ◽  
The Impact

scholarly journals Host immune response in chronic hepatitis C infection: involvement of cytokines and inflammasomes

2020 ◽  
Vol 61 (1) ◽  
pp. 33-43
Author(s):  
Mihail Virgil Boldeanu ◽  
◽  
Isabela Siloşi ◽  
Andreea Lili Bărbulescu ◽  
Raluca Elena Sandu ◽  
...  
Keyword(s):  
Immune Response ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Host Immune Response ◽  
Hepatitis C Infection

Combination therapy with interferona and Гincreases host immune response in patients with chronic hepatitis C

2000 ◽  
Vol 118 (4) ◽  
pp. A1459
Author(s):  
Ryukichi Kumashiro ◽  
Tatsuya Ide ◽  
Masaru Sasaki ◽  
Shiro Murashima ◽  
Hiroshi Suzuki ◽  
...  
Keyword(s):  
Immune Response ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Combination Therapy ◽  
Chronic Hepatitis C ◽  
Host Immune Response

Estimating the impact of hepatitis C virus therapy on future liver-related morbidity, mortality and costs related to chronic hepatitis C

2005 ◽  
Vol 42 (5) ◽  
pp. 639-645 ◽  
Author(s):  
María Buti ◽  
Ramón San Miguel ◽  
Max Brosa ◽  
Juan M. Cabasés ◽  
Montserrat Medina ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
The Impact

scholarly journals Intrahepatic TLR3 and IFNL3 Expressions Are Associated with Stages of Fibrosis in Chronic Hepatitis C

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1103
Author(s):  
Keyla Santos Guedes de Sá ◽  
Ednelza da Silva Graça Amoras ◽  
Simone Regina Souza da Silva Conde ◽  
Maria Alice Freitas Queiroz ◽  
Izaura Maria Vieira Cayres-Vallinoto ◽  
...  
Keyword(s):  
Immune Response ◽  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Control Group ◽  
Gene Expressions ◽  
Healthy Control ◽  
Advanced Stages ◽  
Chronic Hcv

An inefficient immune response against the hepatitis C virus (HCV), combined with viral evasion mechanisms, is responsible for the chronicity of infection. The need to evaluate the innate mechanisms of the immune response, such as TLR3 and IFN-λ3, and their relationship with the virus–host interaction is important for understanding the pathogenesis of chronic hepatitis C. The present study aimed to investigate the gene expressions of TRL3 and IFNL3 in liver tissue, seeking to evaluate whether these could be potential biomarkers of HCV infection. A total of 23 liver biopsy samples were collected from patients with chronic HCV, and 8 biopsies were collected from healthy control patients. RNA extraction, reverse transcription and qPCR were performed to quantify the relative gene expressions of TLR3 and IFNL3. Data on the viral load; AST, ALT, GGT and AFP levels; and the viral genotype were collected from the patients′ medical records. The intrahepatic expression of TLR3 (p = 0.0326) was higher in chronic HCV carriers than in the control group, and the expression of IFNL3 (p = 0.0037) was lower in chronic HCV carriers than in the healthy control group. The expression levels of TLR3 (p = 0.0030) and IFNL3 (p = 0.0036) were higher in the early stages of fibrosis and of necroinflammatory activity in the liver; in contrast, TLR3 and IFNL3 expressions were lower in the more advanced stages of fibrosis and inflammation. There was no correlation between the gene expression and the serum viral load. Regarding the initial METAVIR scale scores, liver transaminase levels were lower in patients with advanced fibrosis when correlated with TLR3 and IFNL3 gene expressions. The results suggest that in the early stages of the development of hepatic fibrosis, TLR3 and IFN-λ3 play important roles in the antiviral response and in the modulation of the tolerogenic liver environment because there is a decrease in the intrahepatic expressions of TLR3 and IFNL3 in the advanced stages of fibrosis, probably due to viral evasion mechanisms.

Immune response in addicts with chronic hepatitis C treated with interferon and ribavirine

2007 ◽  
Vol 22 (1) ◽  
pp. 74-79 ◽  
Author(s):  
Neri Sergio ◽  
Travali Salvatore ◽  
Bertino Gaetano ◽  
Pulvirenti Davide ◽  
Italiano Claudio ◽  
...  
Keyword(s):  
Immune Response ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C

scholarly journals Newer molecules and new hopes in the management of chronic hepatitis C

JMS SKIMS ◽  
2010 ◽  
Vol 13 (2) ◽  
pp. 39-40
Author(s):  
Showkat Ali Zargar
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
Liver Transplantation ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Chronic Infection ◽  
Antiviral Therapies ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

Chronic hepatitis C is highly prevalent with prevalence rate of around 3% involving about 180 million people worldwide, despite major advances in its understanding of viral 1 pathogenesis and significant evolution in antiviral therapies. Most of the patients develop chronic infection because the virus evades the host immune response in majority of patients. Chronic HCV infection can lead to cirrhosis and hepatocellular carcinoma. Complications of HCV-related cirrhosis are the leading indication for liver transplantation in United States and Europe...... J Med Sci 2010;13(2): 39-40.

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