scholarly journals Using Musculoskeletal Models to Estimate in vivo Total Knee Replacement Kinematics and Loads: Effect of Differences Between Models

2021 ◽  
Vol 9 ◽  
Author(s):  
Cristina Curreli ◽  
Francesca Di Puccio ◽  
Giorgio Davico ◽  
Luca Modenese ◽  
Marco Viceconti
Keyword(s):  
Finite Element ◽  
Knee Joint ◽  
Total Knee Replacement ◽  
Finite Element Model ◽  
Knee Replacement ◽  
Element Model ◽  
Assessment Process ◽  
Grand Challenge ◽  
Total Knee

Total knee replacement (TKR) is one of the most performed orthopedic surgeries to treat knee joint diseases in the elderly population. Although the survivorship of knee implants may extend beyond two decades, the poor outcome rate remains considerable. A recent computational approach used to better understand failure modes and improve TKR outcomes is based on the combination of musculoskeletal (MSK) and finite element models. This combined multiscale modeling approach is a promising strategy in the field of computational biomechanics; however, some critical aspects need to be investigated. In particular, the identification and quantification of the uncertainties related to the boundary conditions used as inputs to the finite element model due to a different definition of the MSK model are crucial. Therefore, the aim of this study is to investigate this problem, which is relevant for the model credibility assessment process. Three different generic MSK models available in the OpenSim platform were used to simulate gait, based on the experimental data from the fifth edition of the “Grand Challenge Competitions to Predict in vivo Knee Loads.” The outputs of the MSK analyses were compared in terms of relative kinematics of the knee implant components and joint reaction (JR) forces and moments acting on the tibial insert. Additionally, the estimated knee JRs were compared with those measured by the instrumented knee implant so that the “global goodness of fit” was quantified for each model. Our results indicated that the different kinematic definitions of the knee joint and the muscle model implemented in the different MSK models influenced both the motion and the load history of the artificial joint. This study demonstrates the importance of examining the influence of the model assumptions on the output results and represents the first step for future studies that will investigate how the uncertainties in the MSK models propagate on disease-specific finite element model results.

scholarly journals Total Knee Replacement: Subject-Specific Modeling, Finite Element Analysis, and Evaluation of Dynamic Activities

2021 ◽  
Vol 9 ◽  
Author(s):  
Iliana Loi ◽  
Dimitar Stanev ◽  
Konstantinos Moustakas
Keyword(s):  
Finite Element ◽  
Total Knee Replacement ◽  
Finite Element Model ◽  
Knee Replacement ◽  
Element Model ◽  
Grand Challenge ◽  
Data Set ◽  
Subject Specific ◽  
Total Knee ◽  
Contact Pressures

This study presents a semi-automatic framework to create subject-specific total knee replacement finite element models, which can be used to analyze locomotion patterns and evaluate knee dynamics. In recent years, much scientific attention was attracted to pre-clinical optimization of customized total knee replacement operations through computational modeling to minimize post-operational adverse effects. However, the time-consuming and laborious process of developing a subject-specific finite element model poses an obstacle to the latter. One of this work's main goals is to automate the finite element model development process, which speeds up the proposed framework and makes it viable for practical applications. This pipeline's reliability was ratified by developing and validating a subject-specific total knee replacement model based on the 6th SimTK Grand Challenge data set. The model was validated by analyzing contact pressures on the tibial insert in relation to the patient's gait and analysis of tibial contact forces, which were found to be in accordance with the ones provided by the Grand Challenge data set. Subsequently, a sensitivity analysis was carried out to assess the influence of modeling choices on tibial insert's contact pressures and determine possible uncertainties on the models produced by the framework. Parameters, such as the position of ligament origin points, ligament stiffness, reference strain, and implant-bone alignment were used for the sensitivity study. Notably, it was found that changes in the alignment of the femoral component in reference to the knee bones significantly affect the load distribution at the tibiofemoral joint, with an increase of 206.48% to be observed at contact pressures during 5° internal rotation. Overall, the models produced by this pipeline can be further used to optimize and personalize surgery by evaluating the best surgical parameters in a simulated manner before the actual surgery.

A finite element model for evaluation of tibial prosthesis-bone interface in total knee replacement

1992 ◽  
Vol 25 (12) ◽  
pp. 1413-1424 ◽  
Author(s):  
R.L. Rakotomanana ◽  
P.F. Leyvraz ◽  
A. Curnier ◽  
J.H. Heegaard ◽  
P.J. Rubin
Keyword(s):  
Finite Element ◽  
Total Knee Replacement ◽  
Finite Element Model ◽  
Knee Replacement ◽  
Element Model ◽  
Bone Interface ◽  
Total Knee

Personalized finite element model of the knee joint in vivo

2006 ◽  
Vol 39 ◽  
pp. S501
Author(s):  
M. Sangeux ◽  
F. Marin ◽  
F. Charleux ◽  
L. Dürselen ◽  
M.-C. Ho Ba Thoa
Keyword(s):  
Finite Element ◽  
Knee Joint ◽  
Finite Element Model ◽  
Element Model

A Finite Element Model of a Rotating Platform Total Knee Employing a Nonlinear, Dual-Surface-Contact Formulation

2000 ◽  
Author(s):  
Jason K. Otto ◽  
Thomas D. Brown ◽  
John J. Callaghan
Keyword(s):  
Finite Element ◽  
Finite Element Model ◽  
Mobile Bearing ◽  
Element Model ◽  
Polyethylene Insert ◽  
Rotating Platform ◽  
Mobile Interface ◽  
Surface Contact ◽  
Total Knee

Abstract Mobile bearing total knees avoid the conformity/constraint tradeoff of fixed bearing total knees. However, a recent in vivo fluoroscopic study of the most popular mobile bearing total knee in the U.S. showed that bearing motion failed to occur in half of the patients observed. A nonlinear, multiple-surface contact finite element model of a rotating platform total knee was therefore developed to investigate the interaction at the “mobile” interface (contact between the tibial tray and the polyethylene insert) under physiologically relevant loads (1–4 BW) and rotations (10° endorotation). The data showed that there was a linear relationship between axial load and the torque resisting endorotation. Peak contact stresses were located on the medial and lateral peripheral edges of the polyethylene insert. All relative rotation occurred at the “mobile” interface. The same trends were seen in a complementary experimental study of the same components, suggesting that the finite element model is valid under these loading conditions.

Dual-Joint Modeling for Estimation of Total Knee Replacement Contact Forces During Locomotion

2013 ◽  
Vol 135 (2) ◽  
Author(s):  
Michael W. Hast ◽  
Stephen J. Piazza
Keyword(s):  
Total Knee Replacement ◽  
Knee Replacement ◽  
Knee Flexion ◽  
Joint Modeling ◽  
Contact Forces ◽  
Emg Activity ◽  
Single Subject ◽  
Grand Challenge ◽  
Total Knee

Model-based estimation of in vivo contact forces arising between components of a total knee replacement is challenging because such forces depend upon accurate modeling of muscles, tendons, ligaments, contact, and multibody dynamics. Here we describe an approach to solving this problem with results that are tested by comparison to knee loads measured in vivo for a single subject and made available through the Grand Challenge Competition to Predict in vivo Tibiofemoral Loads. The approach makes use of a “dual-joint” paradigm in which the knee joint is alternately represented by (1) a ball-joint knee for inverse dynamic computation of required muscle controls and (2) a 12 degree-of-freedom (DOF) knee with elastic foundation contact at the tibiofemoral and patellofemoral articulations for forward dynamic integration. Measured external forces and kinematics were applied as a feedback controller and static optimization attempted to track measured knee flexion angles and electromyographic (EMG) activity. The resulting simulations showed excellent tracking of knee flexion (average RMS error of 2.53 deg) and EMG (muscle activations within ±10% envelopes of normalized measured EMG signals). Simulated tibiofemoral contact forces agreed qualitatively with measured contact forces, but their RMS errors were approximately 25% of the peak measured values. These results demonstrate the potential of a dual-joint modeling approach to predict joint contact forces from kinesiological data measured in the motion laboratory. It is anticipated that errors in the estimation of contact force will be reduced as more accurate subject-specific models of muscles and other soft tissues are developed.

scholarly journals Finite element evaluation of the newest ISO testing standard for polyethylene total knee replacement liners

2018 ◽  
Vol 232 (6) ◽  
pp. 545-552 ◽  
Author(s):  
Steven P Mell ◽  
Spencer Fullam ◽  
Markus A Wimmer ◽  
Hannah J Lundberg
Keyword(s):  
Finite Element ◽  
Total Knee Replacement ◽  
Knee Replacement ◽  
External Rotation ◽  
Articular Surface ◽  
Element Model ◽  
International Standards ◽  
Wear Testing ◽  
Contact Conditions ◽  
Total Knee

Current treatment for end-stage osteoarthritis is total knee replacement. Given that the number of total knee replacement surgeries is expected to approach 3.48 million by 2030, understanding long-term failure is important. One of the preclinical tests for total knee replacements is carried out using mechanical wear testing under generic walking conditions. Used for this purpose is the International Standards Organization’s generic walking profile. Recently this standard was updated by reversing the direction of anterior/posterior translation and internal/external rotation. The effects of this change have not been investigated, and therefore, it is unknown if comparisons between wear tests utilizing the old and new version of the standard are valid. In this study, we used a finite element model along with a frictional energy–based wear model to compare the kinematic inputs, contact conditions, and wear from the older and newer versions of the ISO standard. Simulator-tested components were used to validate the computational model. We found that there were no visible similarities in the contact conditions between the old and new versions of the standard. The new version of the standard had a lower wear rate but covered a larger portion of the articular surface. Locations of wear also varied considerably. The results of the study suggest that major differences between the old and new standard exist, and therefore, historical wear results should be compared with caution to newly obtained results.

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