scholarly journals Evidence for Recipient-Derived Cells in Peribiliary Glands and Biliary Epithelium of the Large Donor Bile Ducts After Liver Transplantation

2020 ◽  
Vol 8 ◽  
Author(s):  
Iris E. M. de Jong ◽  
Michael E. Sutton ◽  
Marius C. van den Heuvel ◽  
Annette S. H. Gouw ◽  
Robert J. Porte
Keyword(s):  
Liver Transplantation ◽  
Bile Ducts ◽  
Biliary Epithelium ◽  
Peribiliary Glands

scholarly journals Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Yinka K. Davies ◽  
Cynthia J. Tsay ◽  
Dario V. Caccamo ◽  
Kathleen M. Cox ◽  
Ricardo O. Castillo ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Liver Transplantation ◽  
Primary Sclerosing Cholangitis ◽  
Orthotopic Liver Transplantation ◽  
Successful Treatment ◽  
Sclerosing Cholangitis ◽  
Bile Ducts ◽  
Biliary Tree ◽  
Oral Vancomycin ◽  
Inflammatory Bowel

Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis and cirrhosis of the liver. Due to limited understanding of the etiology and mechanism of PSC, the only existing treatment option is orthotopic liver transplantation (OLT); however, recurrence of PSC, after OLT is estimated to be between 5% and 35%. We discuss the successful treatment of a pediatric patient, with recurrent PSC, after OLT with oral Vancomycin.

Paucity of Interlobular Bile Ducts in Multidrug-Resistant P-Glycoprotein 3 (MDR3) Deficiency

2018 ◽  
Vol 27 (3) ◽  
pp. 343-347 ◽  
Author(s):  
Mukul Vij ◽  
Joseph Valamparampil ◽  
Naresh Shanmugum ◽  
Srinivas Mettu Reddy ◽  
Shaman Rajindrajith ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Bile Ducts ◽  
Multidrug Resistant ◽  
Homozygous Deletion ◽  
Second Child ◽  
Donor Liver Transplantation ◽  
P Glycoprotein ◽  
Explanted Liver ◽  
Base Pair Deletion ◽  
Abcb4 Gene

Multidrug-resistant P-glycoprotein 3 (MDR3) is a phospholipid translocator encoded by the ABCB4 gene located on chromosome 7. MDR3 mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte into bile. Severe MDR3 deficiency typically occurs during childhood with progressive cholestasis evolving to cirrhosis and liver failure, requiring liver transplantation. In this article, we report 2 pediatric cases of severe MDR3 deficiency with paucity of interlobular bile ducts. Both underwent living donor liver transplantation at our center for decompensated liver disease and portal hypertension. We diagnosed severe MDR3 deficiency in both the cases with negative MDR3 immunostaining in the explanted liver. Genetic studies revealed homozygous deletion single base pair deletion in exon 24 of the ABCB4 gene in the second child. The patients are on regular follow-up after liver transplant and are doing well. Our report highlights that cholangiopathy in MDR3 deficiency can lead to ductopenia in pediatric livers.

Injury to peribiliary glands and vascular plexus before liver transplantation predicts formation of non-anastomotic biliary strictures

2014 ◽  
Vol 31 (4) ◽  
pp. 230-231
Author(s):  
S. op den Dries ◽  
A.C. Westerkamp ◽  
N. Karimian ◽  
A.S.H. Gouw ◽  
B.G. Bruinsma ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Biliary Strictures ◽  
Vascular Plexus ◽  
Peribiliary Glands

Raised pressure in the bile ducts after orthotopic liver transplantation

1994 ◽  
Vol 7 (4) ◽  
pp. 243-246 ◽  
Author(s):  
A. Thune ◽  
S. Friman ◽  
H. Persson ◽  
B. Berglund ◽  
B. Nilsson ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Bile Ducts

Aberrant bile ducts, ‘remnant surface bile ducts,’ and peribiliary glands: Descriptive anatomy, historical nomenclature, and surgical implications

2011 ◽  
Vol 24 (4) ◽  
pp. 429-440 ◽  
Author(s):  
Ramadan M. El Gharbawy ◽  
Lee J. Skandalakis ◽  
Thomas G. Heffron ◽  
John E. Skandalakis
Keyword(s):  
Bile Ducts ◽  
Peribiliary Glands

Influence of Ischemia Time in Injury of Deep Peribiliary Glands of the Bile Ducts Graft: A Prospective Study

2019 ◽  
Vol 51 (5) ◽  
pp. 1545-1548
Author(s):  
D. Diogo ◽  
C. Pacheco ◽  
R. Oliveira ◽  
R. Martins ◽  
P. Oliveira ◽  
...  
Keyword(s):  
Prospective Study ◽  
Bile Ducts ◽  
Ischemia Time ◽  
Peribiliary Glands ◽  
A Prospective Study

RhGH Attenuates Ischemia Injury of Intrahepatic Bile Ducts Relating to Liver Transplantation

2011 ◽  
Vol 171 (1) ◽  
pp. 300-310 ◽  
Author(s):  
Zheng Wang ◽  
Jie Zhou ◽  
Jianhua Lin ◽  
Yu Wang ◽  
Yixiong Lin ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Bile Ducts ◽  
Intrahepatic Bile Ducts

Severe histological injury of common bile ducts in donation after circulatory death liver transplantation

2018 ◽  
Vol 68 ◽  
pp. S27
Author(s):  
F. Tinti ◽  
I. Umbro ◽  
S.G. Hubscher ◽  
J. Isaac ◽  
P. Onori ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Bile Ducts ◽  
Donation After Circulatory Death ◽  
Circulatory Death
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